Searchable abstracts of presentations at key conferences in endocrinology

ea0020p543 | Growth Factors | ECE2009

Effects of intraperitoneal gibberelic acid (GA3) on IGF-1 and growth hormone (GH) in the rats

Afacan Berna , Erin Nuray , Ulusoy Ozkan , Balci Mustafa Kemal

Plant growth factors are used commonly in agriculture. The effect of these factors on human health is unknown. Gibberellins are the most commonly used growth factors that have the structure of Diterpenoid acid. One of the gibberellins (GA3) induces tumor formation in mice but the mechanism of action is not known. We here examined changes in levels of GH and IGF-1 and examined whether there is a correlation between growth factors’ levels and weight changes.<p class="ab...

ea0037ep916 | Thyroid cancer | ECE2015

Differentiated thyroid carcinoma prevalence in the Graves' disease; Akdeniz University experience

Balci Mustafa Kemal , Koyuncu Birsen Unsal , Arik Safiye , Arici Cumhur , Sari Ramazan , Altunbas Hasan Ali

Objective: The frequency of differentiated thyroid cancer in the Graves’ disease are controversial. The aim of this study was to evaluate the frequency of thyroid cancers in patients operated because of Graves’ disease.Subjects and methods: Sixty-six patients in whom thyroidectomy was performed because of Graves’ disease between 2001 and 2012 were evaluated retrospectively. Patients who had received radioactive iodine treatment and externa...

ea0035p74 | Bone and Osteoporosis | ECE2014

The relationship between the existence and degree of coronary atherosclerosis with the level of parathormone

Beypinar Ismail , Oncel Ramazan Can , Ozdem Sebahat , Balci Mustafa Kemal , Sari Ramazan , Altunbas Hasan Ali

Introduction: Parathormone (PTH) is one of the major regulator of the bone and mineral metabolism. Elevated PTH levels in patients with primary and secondary hyperparathyroidism is thought to have negative effects on the cardiovascular system. In our study, we aimed to investigate a possible relationship between plasma PTH levels and coronary atherosclerosis.Methods: Fourty-two men and 35 women, a total of 77 patients were included the study who admitted...

ea0035p131 | Calcium and Vitamin D metabolism | ECE2014

Evaluation of biochemical cardiovascular risk factors, carotid intima media thickness, and arterial stiffness before and after surgery in patients with primary hyperparathyroidism

Cansu Guven Baris , Ozdem Sebahat , Suleymanlar Gultekin , Sari Ramazan , BAlcI Mustafa Kemal , Altunbas Hasan Ali

Primary hyperparathyroidism is a condition related with cardiovascular mortality and morbidity. Aim of this study is to investigate whether there is a difference between healthy controls, hypercalcemic patients with surgical decision and normocalcemic primary hyperparathyroidism patients for parameters like metabolic cardiovascular risk factors, carotis intima media thickness and pulse wave velocity and if there is a difference at patients with surgical decision 6 months after...

ea0035p900 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Diabetes insipidus secondary to hypothalamus and pituitary metastasis

Bakirtas Mehmet , Yilmaz Nusret , Arik Safiye , Sari Ramazan , Altunbas Hasan Ali , Balci Mustafa Kemal

Introduction: The most common cause of diabetes insipidus is idiopathic. However, it may be also seen after metastasis to hypothalamic–pituitary region.Case: Fifty year old female patient with breast cancer was referred to our clinic with complaints of polyuria and polydipsia. Two years ago, she had diagnosed and after surgery, she has taken three cycles of cyclophosphamide+adriamycin+5-flurourasil than three cycles dosetaxel and finally seventeen c...

ea0020p336 | Diabetes and Cardiovascular | ECE2009

Comparative molecular analysis of TRAIL ligand and receptor expression profiles in cyclophosphamide versus streptozotocin-induced diabetes in non-obese diabetic (NOD) mice

Kahraman Sevim , Dirice Ercument , Elpek Ozlem , Balci Mustafa Kemal , Omer Abdulkadir , Sanlioglu Salih , Sanlioglu Ahter

Background: NOD mice are the most frequently preferred animal models in type 1 diabetes (T1D) research. They develop spontaneous disease in 24 to 30 months. T1D can also chemically be induced in NOD mice for a faster disease progression. Two commonly used diabetes-inducing agents are Streptozotocin (STZ), which destructs pancreatic beta cells mainly through DNA fragmentation, and Cyclophosphamide (CY), which acts on suppressor T cells. TNF-Related Apoptosis-Inducing Ligand (TR...

ea0020oc2.1 | Diabetes &amp; Obesity | ECE2009

ESE Young Investigator Award

Dirice Ercument , Sanlioglu Ahter Dilsad , Kahraman Sevim , Omer Abdulkadir , Balci Mustafa Kemal , Griffith Thomas S , Sanlioglu Salih

Background: Because type 1 diabetes (T1D) results from the T cell-mediated destruction of the insulin-producing pancreatic beta cells, the depletion of the autoreactive T cells via apoptosis represents a viable strategy for the prevention of autoimmune diabetes. The functional role TNF Related Apoptosis Inducing Ligand (TRAIL), a novel member of TNF superfamily, in autoimmune diabetes remains unknown. To understand this, TRAIL function was counteracted by an injection of solub...