Searchable abstracts of presentations at key conferences in endocrinology

ea0063p640 | Interdisciplinary Endocrinology 1 | ECE2019

Different regulation of erythropoietin and VEGF in clear renal cell carcinoma

Cokic Bojana Beleslin , Macut Djuro , Milicevic Ivana , Rodic Gordana , Bankovic Jovana , Antic Jadranka , Noguchi Constance , Damjanovic Svetozar

Clear renal cell carcinoma (ccRCC) is a highly vascularized and proliferative tumor. ccRCC can be sporadic or familiar, usually associated with von Hippel-Lindau (VHL) gene mutations. VHL protein is part of the E3 ubiquitin ligase complex that regulates hypoxia-inducible factor (HIF). When a defective and inactive VHL protein is produced, HIF is not degraded, resulting in over-expression of hypoxia related genes including erythropoietin (EPO) and vascular endothelial growth fa...

ea0014p285 | (1) | ECE2007

Frequency of three major glucocorticoid receptor gene polymorphisms in patients with adrenal incidentalomas

Antic Jadranka , Cokic Bojana Beleslin , Ognjanovic Sanja , Vignjevic Jovana , Mirkovic Katarina , Nikolic Jelena , Paunovic Ivan , Damjanovic Svetozar

Background: Several polymorphisms of glucocorticoid receptor (GR) gene, including BclI, N363S and ER22/23EK, which may have an influence on glucocorticoid sensitivity, have been reported. BclI and N363S polymorphisms have been associated with clinical characteristics of increased and ER22/23EK of decreased glucocorticoid (GC) effects. On the other hand, metabolic syndrome has been described in patients with adrenal incidentalomas.Objective ...

ea0032p893 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Myeloproliferative neoplasms in patients with acromegaly

Isailovic Tatjana , Beleslin Bojana , Lalic Nebojsa , Lukic Ljiljana , Popovic Bojana , Petakov Milan , Macut Djuro , Ognjanovic Sanja , Elezovic Valentina , Bozic Ivana , Bogavac Tamara , Ilic Dusan , Pekmezovic Tatjana , Damjanovic Svetozar

Introduction: Generously supported by IPSEN)-->The coexistence of acromegaly and secondary polycythemia has been described in a few patients. This association was ascribed to GH/IGF1 proliferative effect on bone marrow progenitor cells. In contrast, the presence of myeloproliferative neoplasm (MPN) with documented JAK2 mutation so far has been described in only one acromegalic patient.Methods: We analyzed the p...

ea0014oc4.6 | Neuroendocriology basis | ECE2007

Metabolic abnormalities in patients with adrenal adenomas may be associated with BclI polymorphism in the glucocorticoid receptor (GR) gene and expression of tumor-specific hsp70 isoforms

Damjanovic Svetozar , Antic Jadranka , Beleslin Bojana , Ognjanovic Sanja , Vignjevic Jovana , Petakov Milan , Macut Djuro , Paunovic Ivan , Isailovic Tatjana , Popovic Bojana , Bozic Ivana

Introduction: Intronic BclI polymorphism of glucocorticoid receptor (GR) gene and adrenal adenomas of incidental discovery are frequently associated with metabolic syndrome. We studied in these patients metabolic and hormonal parameters, the sequence alteration in BclI polymorphism of the GR gene from constitutive DNA and the expression of Hsp70 within the tumor and in tissue adjacently to tumor.Patients and methods: We assessed 114 healthy...

ea0013p327 | Thyroid | SFEBES2007

RET proto-oncogene exon 11 germline mutations in patients with medullary thyroid carcinoma

Petakov Milan , Nikolic Jelena , Katarina Mirkovic , Jadranka Antic , Jovana Vignjevic , Bojana Beleslin-Cokic , Tatjana Isailovic , Sanja Ognjanovic , Djuro Macut , Svetozar Damjanovic

Several RET proto-oncogene germline mutations with dominant inheritance, predispose to hereditary medullary thyroid carcinoma (MTC), and whether the MTC is sporadic or hereditary should be determined by a direct analysis of the RET proto-oncogene. 85% of MEN IIA patients and 30% of patients with familial medullary thyroid carcinoma have mutations at codon 634 (exon 11). In 88 consecutive patients with MTC, the characterization of RET mutations in exon 11 had been done by PCR w...