Endocrine Abstracts

Obesity belongs to the five most important health burdens in modern societies and reaches with ~20% prevalence in Germany epidemic proportions. Obesity significantly increases the risk of developing metabolic (e.g. type 2 diabetes), cardiovascular, orthopaedic, psychologic, and other disorders. Despite the well established epidemiologic relationship between obesity and these co-morbidities, there is a subgroup of metabolically healthy obese patients, which seems to be protecte...

Tumor necrosis factor alpha-induced adipose-related protein (TIARP)/six-transmembrane protein of prostate 2 (STAMP2) has been characterized as an adipocyte-expressed protein which might play a crucial role in metabolic homeostasis and inflammatory pathways. In the current study, the impact of insulin resistance-inducing and proinflammatory interleukin (IL)-1ß on TIARP/STAMP2 gene expression was determined by quantitative real-time reverse transcription-polymerase chain re...

Background: The crosstalk between the adrenal gland and different fat depots is largely unknown. As primary hyperaldosteronism leads to an increased risk of cardiovascular disease and associated pathologies (glucose intolerance, diabetes, hyperlipidemia), elucidating the interaction between aldosterone producing adenomas (APAs) and different fat depots might help to understand causality and open new diagnostic and treatment strategies.Methods: Subcutaneo...