Searchable abstracts of presentations at key conferences in endocrinology

ea0063p1108 | Pituitary and Neuroendocrinology 3 | ECE2019

Variability of momentarily measured fatigue in patients with pituitary insufficiency receiving hydrocortisone replacement therapy

Boesen Victor Brun , Watt Torquil , Borresen Stina Willemoes , Klose Marianne , Feldt-Rasmussen Ulla

Background: Secondary adrenal insufficiency is usually treated with hydrocortisone replacement therapy twice or thrice daily in varying doses to mimic the physiological rhythm of cortisol release. However, despite efforts to optimize treatment regimens patients report impaired quality of life (QoL), including important aspects such as fatigue. A possible explanation is a suboptimal imitation of cortisol release resulting in an inadequate substitution at certain times during th...

ea0056p1082 | Thyroid (non-cancer) | ECE2018

How should thyroid-related quality of life be assessed? Standard recall measures compared with here-and-now measures

Boesen Victor Brun , Feldt-Rasmussen Ulla , Bjorner Jakob Bue , Cramon Per , Gronvold Mogens , Nygaard Birte , Rasmussen AEse Krogh , Vilsboll Tina , Watt Torquil

Introduction: Some methodologists have raised concern about the validity of the standard method of assessing patient-reported outcomes, i.e. retrospective questionnaires. Repeated momentary measurements have been introduced to avoid recall bias and provide ecological validity. Although having theoretical advantages, the measurement properties remain unsubstantiated. This study examines the relationship between the retrospective thyroid-related quality of life patient-reported ...

ea0090rc9.1 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Symptoms of glucocorticoid-induced adrenal insufficiency – A systematic evaluation of clinician- and patient-reported symptoms and their rated relevance

Lund Marie Louise , Bjorner Jakob Bue , Al-Jorani Hajir , Boesen Victor Brun , Dreyer Anja Fenger , Boggild Hansen Simon , Jorgensen Nanna Thurmann , Klose Marianne , Tei Randi , Watt Torquil , Feldt-Rasmussen Ulla , Borresen Stina Willemoes

Context: Glucocorticoid-induced adrenal insufficiency is the most frequent type of adrenal insufficiency, but its symptomatology has not been thoroughly studied.Objective: To describe the predominant symptoms experienced by patients with glucocorticoid-induced adrenal insufficiency and rate these symptomsÂ’ significance for patientsÂ’ perceived need for supplemental hydrocortisone stress dose.Methods: The 80 symptoms in the...

ea0090ep23 | Adrenal and Cardiovascular Endocrinology | ECE2023

REPLACE: Effect of hydrocortisone and placebo in patients with partial adrenal insufficiency after cessation of glucocorticoid treatment; A study protocol for a multi-centre, randomised, double-blinded, placebo-controlled clinical trial

Dreyer Anja Fenger , Borresen Stina Willemoes , Hansen Simon Boggild , Al-Jorani Hajir , Bislev Lise Sofie , Boesen Victor Brun , Christensen Louise Lehmann , Glintborg Dorte , Jensen Richard Christian , Jorgensen Nanna Thurmann , Klose Marianne , Lund Marie Louise , Stankovic Jelena , Tei Randi , Watt Torquil , Feldt-Rasmussen Ulla , Jorgensen Jens Otto , Andersen Marianne

Background: Glucocorticoid (GC) formulations are widely used as anti-inflammatory treatment, and synthetic GC, e.g. prednisolone, is the cornerstone treatment of polymyalgia rheumatic (PMR) and giant cell arteritis (GCA). Long-term pharmacological GC treatment may induce adrenal insufficiency (GIA). Adrenal function is, however, not routinely assessed after discontinuation of long-term GC treatment, and it is unknown, if hydrocortisone replacement is beneficial. This study aim...