Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep586 | Endocrine-related Cancer | ECE2023

Parathyroid carcinoma in a patient with both MEN1 and RET mutations

Pylina Svetlana , Kim Ekaterina , Bondarenko Ekaterina , Krupinova Julia , Eremkina Anna , Mokrysheva Natalia

Background: MEN1-related primary hyperparathyroidism (PHPT) characterised by benign course, whereas malignant transformation is extremely rare. The diagnosis of parathyroid carcinoma (PC) within the MEN-1 syndrome is a challenge for a range of specialists.Clinical case: A 47-year Eastern European female. PHPT had been revealed during examination for multinodular goitre: PTH 614 nmol\l, calcium 3.06 mmol\l. Results of imaging methods were controversial (m...

ea0049ep685 | Obesity | ECE2017

Association of Transforming growth factor β and Fibroblast growth factor 21 with cardiovascular diseases in obese patients

Shvangiradze Teona , Troshina Ekaterina , Bondarenko Irina , Shestakova Marina , Nikankina Larisa

Introduction: Obesity and type 2 diabetes mellitus (T2DM) are associated with cardiovascular diseases (CVD). Fibrotic changes in obesity include several molecular processes, including activation of Transforming growth factor β (TGF-β). Recent data indicate the involvement of Fibroblast growth factor 21 (FGF-21) as an important metabolic regulator, and even biomarker of metabolic changes in obesity and T2DM.Aim: To determine TGF-β and FGF-2...

ea0090ep584 | Endocrine-related Cancer | ECE2023

Patient-derived three-dimensional model of papillary thyroid cancer for personalized medicine and testing of novel therapies

Petrova Daria , Bastrich Asya , Abilov Zaur , Bondarenko Ekaterina , Urusova Liliya , Nikiforovich Petr , Belcevich Dmitry , Pylina Svetlana , Eremkina Anna , Kim Ekaterina , Mokrysheva Natalia

Introduction: Over the last decades, there has been a significant increase in the incidence of thyroid cancer. Papillary thyroid cancer (PTC) is the most common histopathological type with often a favorable prognosis. Conventional therapies include surgical resection, adjuvant therapy with radioactive iodine, and suppressive therapy with thyroid hormones. However, the prognosis for iodine-resistant/refractory thyroid cancers or the advanced metastatic cancer is less favorable....