Endocrine Abstracts

Background: CYP24A1 gene encodes the enzyme vitamin D 24-hydroxylase, which converts active vitamin D to inactive metabolites. More than 20 currently described, usually biallelic pathogenic variants of this gene are responsible for idiopathic infantile hypercalcemia manifested typically in childhood (often in newborns) with hypercalcemia, hypercalciuria and nephrocalcinosis. However, a few patients (mostly with monoallelic heterozygous pathogenic variant) can develop mild symp...

Introduction: We tested our hypotheses that higher anxiety/depression scores can be connected with food preference of carbohydrates and higher insulin resistance.Methods: We examined 42 healthy men (average age 43.5±7.4 years, average BMI 27.4±5.7 kg/m2). Study protocol included filling in the self-asssessing scores of anxiety (SAS) resp. depression (SDS), carbohydrate-craving questionnaire (CCQ); assessment of 3-days diet records, h...

Background: Dopaminergic agonists have been proved to improve control of diabetes and lipids. Central dopaminergic activity can be measured by apomorphin test (apomorphin increases GH and decreases prolactin levels, which is a marker of dopaminergic activity).The aim of our study was to evaluate the relationship between central dopaminergic activity and metabolic parameters in healthy men.Methods: We examined 42 healthy men (averag...

Objective: Higher anxiety/depression scores can be connected with food preference of carbohydrates, with increased insulin secretion and thus can lead to insulin resistance. Three hypotheses were postulated: 1. more depressive (still in the normal range) subjects do not differ in the central serotoninergic activity from those less depressive. 2. the former do not differ in food preference and 3. in insulin resistance from the latter.Methods: healthy men,...