Searchable abstracts of presentations at key conferences in endocrinology

ea0038p201 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

eNAMPT-monomer plays a critical role in pathophysiology of experimental diabetes and represents a novel target for treatment of type 2 diabetes

Kieswich Julius , Silvestre Marta , Harwood Steven , Yaqoob Muhammad , Caton Paul

Extra-cellular nicotinamide phosphoribosyltransferase (eNAMPT; also referred to as visfatin/PBEF) concentrations are elevated in serum of patients with type 2 diabetes (T2D). However, the relationship between abnormally elevated serum eNAMPT and the pathophysiology of T2D is unclear. eNAMPT circulates in functionally and structurally distinct monomer and dimer forms. eNAMPT-dimer exerts NAD-biosynthetic activity. The role of eNAMPT-monomer is unclear but may exert NAD-independ...

ea0077lb42 | Late Breaking | SFEBES2021

Identifying biomarkers of psoriasis-driven metabolic disease

Gesheva Vesela , Sayers Sophie , Evans Elizabeth , Bewick Gavin , Hannen Rosalind , Caton Paul

Background: Inflammatory skin diseases such as psoriasis induce changes in the skin-secretome, which potentially lead to dysfunction of key metabolic tissues and increased risk of psoriasis co-morbidities, such as type 2 diabetes (T2D). However, the proteins and peptides that make up the skin-secretome remain poorly characterised. Proteomic analysis has identified vimentin, parathymosin, prothymosin-alpha, dermcidin, and desmin as potential skin-secretome factors, which may in...

ea0059p102 | Diabetes & cardiovascular | SFEBES2018

Skin-endocrine regulation of whole-body metabolism

Evans Elizabeth , Kodji Xenia , Sayers Sophie , Brain Sue , Philpott Mike , Hannen Rosalind , Caton Paul

The inflammatory skin disease psoriasis is an independent risk-factor for development of insulin resistance. However, the underlying mechanisms remain poorly elucidated. We used human and mouse models of psoriasis to investigate a potential endocrine role of the skin in regulating subcutaneous adipose tissue (sAT) and pancreatic islet function. Mice were administered a daily topical dose (75 mg) of imiquimod (IMQ), or Vaseline control, to a shaved dorsal region for 4 days. IPG...

ea0065p218 | Metabolism and Obesity | SFEBES2019

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) prevents cytokine-mediated beta cell dysfunction

Egbase Daniel , Sayers Sophie , Evans Elizabeth , Butterworth Sam , Greally Joshua , Bewick Gavin , Tsakmaki Anastasia , Persaud Shanta , Caton Paul

Intracellular nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD salvage pathway. Abnormally elevated NAMPT can promote autoimmune and inflammatory processes. Many of these processes are key to type 1 diabetes (T1D) pathogenesis. Whilst NAMPT has been examined in other inflammatory diseases, the role of NAMPT in T1D remains unclear. To investigate the role of NAMPT in T1D, we used small molecule NAMPT modulators to determine the role of abnor...