Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep664 | Female Reproduction | ECE2016

The first hungarian preimplantational karyomapping In men2a syndrome – case report

Csajbok Eva , Csenki Marianna , Nanassy Laszlo , Fazekas Anita , Vereczkey Attila

The case: The multiplex endocrine neoplasia 2A (MEN2A) syndrome is a monogenic disease caused by mutation of the RET protooncogene leading to medullary thyroid cancer (MTC), pheochromocytoma and primary hyperparathyroidism. The specific mutations determine the timing of the preventive thyroidectomy. In 2007, in a 26 year old female patient, after detailed endocrine investigation, total thyroidectomy with both sided lateral neck lymph node dissection was performed because of su...

ea0035p567 | Endocrine tumours and neoplasia | ECE2014

Neuroendocrine carcinomas of the thymus: two case reports

Sepp Krisztian , Csajbok Eva , Magony Sandor , Julesz Janos , Valkusz Zsuzsanna

The neuroendocrine tumor of thymus (TNET) is an extremely rare disease. It can occur sporadically or as a part of the multiple endocrine neoplasia (MEN1) syndrome. TNET may secret hormons (ectopic ACTH production). It is a potentially malignant tumor which often develops distant metastases. Its prognostic factors are the tumor size, histological grade, Ki67 index, paraneoplastic symptoms, surgical resection and Masaoka staging. The options for treatment are radical surgery, ch...

ea0032p320 | Clinical case reports - Thyroid / Others | ECE2013

Torsade de pointes caused by gluten sensitive enteropathy leading to multiplex endocrine failure: case report

Csajbok Eva , Orosz Andrea , Hankovszky Peter , Rudas Laszlo , Lengyel Csaba

A 55 year-old man was brought to the emergency room because of hypotension, fatigue, fever and pain in the left shoulder. The blood glucose, sodium, potassium levels were normal. ECG showed 65/min sinus rhythm with negative T waves in the precordial leads. Blood pressure was 70/50 mmHg. Suddenly torsade des pointes occurred, which was converted to sinus rhythm with 300 mg amiodarone. Coronarography showed no significant stenosis on epicardial coronaries. During the interventio...

ea0022p250 | Clinical case reports and clinical practice | ECE2010

Different manifestations of polyglandular autoimmune syndrome in HLA-identical monozygous twins

Csajbok Eva , Magony Sandor , Valkusz Zsuzsanna , Panczel Pal , Julesz Janos

The polyglandular autoimmune syndromes (PAS) comprise a wide spectrum of autoimmune disorders and are divided into a very rare juvenile (type I) and a relatively common adult type with (type II) or without adrenal failure (PAS III). For PAS II/III, susceptibility genes are known inreasing the risk for developing autoimmune disorders, but without being causative. Actual diagnosis of PAS involves serological measurement of organ-specific autoantibodies and subsequent functional ...

ea0037ep884 | Thyroid cancer | ECE2015

Simultaneous occurrence of medullary and papillary thyroid microcarcinomas: case report

Sepp Krisztian , Csajbok Eva , Magony Sandor , Tiszlavicz Laszlo , Tobias Balint , Patocs Attila , Valkusz Zsuzsanna

Thyroid cancers represent ~1% of new cancer diagnoses. Thyroid malignancies are divided into papillary carcinomas (80%), follicular carcinomas (10%), medullary carcinomas (5–10%), anaplastic carcinomas (1–2%), and other rare tumours (primary thyroid lymphomas and primary thyroid sarcomas). The main therapeutic options are surgery (mainly total thyreoidectomy), radioiodine treatment, levothyroxine therapy (TSH suppression dose), others (external beam irradiation, chem...

ea0035p645 | Female reproduction | ECE2014

How to estimate insulin resistance in PCOS patients: HOMA-IR or QUICKI?

Csajbok Eva , Gyoi Alexandra , Katona Renata , Magony Sandor , Sepp Krisztian , Valkusz Zsuzsanna

Insulin resistance affects 50–70% of women with polycystic ovary syndrome (PCOS).The aim of our study was to estimate the prevalence of insulin resistance by different methods in a single cohort of 63 PCOS patients diagnosed by the Rotterdam criteria.Methods: Anthropometric measurement, examination and fasting blood tests were made on the 3–5th days of their periods. HOMA-IR (cut off >2.5) and QUICKI (cut off <0.3...

ea0035p858 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

A case of IgG4-related xanthomatous hypophysitis

Csajbok Eva , Magony Sandor , Sepp Krisztian , Valkusz Zsuzsanna , Barzo Pal , Tiszlavicz Laszlo

Introduction: Hypophysitis is an inflammatory disease of the pituitary that may mimic tumors. Primary hypophysitis has been classified as lymphocytic (LH), granulomatous (GH), and xanthomatous (XH). It has been recently proposed to be an IgG4-related autoimmune disease (serum IgG4 concentration: 135 mg/dl), proven by tissue IgG4 immunostaining.Case description: A 23-year-old men suffered from typical cluster type headache. Two years after the first sympt...

ea0032p228 | Clinical case reports – Pituitary/Adrenal | ECE2013

Xanthomatous hypophysitis as a cause of cluster headache: a case report

Csajbok Eva , Magony Sandor , Sepp Kirsztian , Valkusz Zsuzsanna , Barzo Pal , Tiszlavicz Laszlo

Introduction: Hypophysitis is an inflammatory disease of the pituitary gland that may mimic pituitary tumors clinically and radiologically. Primary hypophysitis has traditionnaly been classified as lymphocytic (LH), granulomatous (GH), and xanthomatous (XH).Case description: We report on a case of a xanthomatous hypophysitis initially diagnosed as pituitary adenoma. A 23-year-old men suffered from typical cluster type headache. Two years after the first ...

ea0032p570 | Endocrine tumours and neoplasia | ECE2013

Various neuroendocrine tumors in a multiple endocrin neoplasia type 1 family with the same genetic background

Sepp Krisztian , Csajbok Eva , Magony Sandor , Julesz Janos , Patocs Attila , Racz Karoly , Valkusz Zsuzsanna

Introduction: Multiple endocrine neoplasia (MEN) type 1 is a rare congenital disease with genetic background. The MEN-1 gene encodes menin protein, that acts as a tumor suppressor. Mutation of one allele and the inactivation of the other allele of this gene lead to clonal proliferation and to the development of tumors. The clinical manifestation of MEN type 1 is a combination of endocrine (parathyroid adenomas, entero-pancreatic neuroendocrine tumors, pituitary tumors) and non...

ea0022p31 | Adrenal | ECE2010

Adrenocortical cancer: any hope? case reports

Valkusz Zsuzsanna , Magony Sandor , Csajbok Eva , Gardi Janos , Kiss Ildiko , Julesz Janos

Adrenocortical cancer is a rare and heterogenous malignancy with incompletely understood pathogenesis and poor prognosis. Sometimes patients present with hormonal excess symptoms (e.g. virilization, Cushing’s syndrome) or local symptoms consistent with abdominal space-occupation (median tumor size at the time of diagnosis may be >10 cm). Three cases are presented to give an overview of how adrenocortical cancer is currently managed. Tumors typically appear inhomogenou...