Endocrine Abstracts

Background: Osteoporosis is a common problem in postmenoausal women. There is limited data about the physiological importance of endogenous testosterone on bone mineral density (BMD) in older women is poorly understood.Aim: The aim of this study was to evaluate association of endogeneous testosterone with BMD and BMI.Materials-methods: This cross-sectional study included 64 patients (45–85 year) postmenopausal women; their dem...

Introduction: Acromegaly patients are known to have an increased risk of malignancies. This may be as a result of the effect of insulin-like growth factor I (IGF-I) on cellular proliferation and apoptosis inhibition. Although there are various reports related with hematological malignancies in children who treated with growth hormone (GH), few data are available about hematological malignancies in acromegaly patients. Here, we report a patient with acromegaly who has been deve...

Introduction: Rathke’s cleft cyst is one of the pituitary non-adenomatous tumors that found in about 20% of pituitary glands at autopsy. Symptomatic Rathke’s cleft cysts are rarely, but these cysts can cause serious medical problems associated with compression of the pituitary gland, pituitary stalk, optic nerve or hypothalamus. Here, we report a rare case of 73 years old man with sudden onset headache due to Rathke’s cleft cyst present with symptoms and radiolo...

Introduction: Ectopic and atypically localized parathyroid adenomas such as in the anterior mediastinum, paraesophageal or retrotracheal position, although rare, can be seen in clinical practice. Ultrasound (US) which is a frequently used and one of the best conventional imaging modality sometimes fails to identify the lesion especially in atypically localized adenomas. Endoscopic US (EUS) is a new technique that can be used for localization of parathyroid lesions. We reported...

Introduction: Parathyroid lipoadenoma (PLA) is a rarely seen, benign variant of parathyroid adenoma (PA). However, PA usually consists of uniform, polygonal chief cells with a few nests of oxyphil cells, PLA consists of similar histologic features, but with an abundance of fat cells. Additionally, PLA may be functional with the secretion of parathyroid hormone (PTH) or non-functional. Here, we present a case of atypical PLA presented with severe hypercalcemia and skeletal defo...

Introduction: Primary hyperparathyroidism (pHPT) during pregnancy is rare and associated with increased morbidity for both mother and fetus. Maternal complications of pHPT include nepfhrolithiasis, pancreatitis, cardiac arrhytmias, hypertension, nausea and vomiting. pHPT is caused by a solitary adenoma in 85–90% of patients, and the curative treatment is parathyroidectomy. Here, we presented two women who have diagnosed pHPT and operated without complications in pregnancy...

Introduction: Association between high thyrotrophin receptor antibodies (TRAb) and relapse of thyroid cancer in Graves’ patients was reported previously. In this study, we aimed to investigate possible relation between TRAb and thyroid malignancies in patients with toxic multinodular (TMNG) and toxic nodular goiter (TNG).Methods: Thyroidectomized patients with a preoperative diagnosis of TMNG, TNG and euthyroid multinodular or nodular goiter (MNG/NG...

Introduction: The predictors of malignancy are important for decision of appropriate management in nodules with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS). Our aim was to determine the ultrasonographical, clinical and biochemical predictors of malignancy in these patients.Methods: A total of 427 patients with Bethesda Category III (AUS/FLUS) thyroid nodules were included in this retrospective study. We d...

Introduction: In recent years, due to the improvements in ultrasonography (US), it has become possible to gain more information about the papillary throid carcinoma (PTC) and papillary tyroid microcarcinoma (PTMC). However, whether PTC and PTMC exhibit the same ultrasonographic features and behave same features is controversial. We aimed to evaluate the patients diagnosed with PTC and PTMC in terms of clinical, ultrasonographical (US) and histopathological features and their r...

Background: The characteristics of multifocal PTC remain controversial. Surgical approach to multifocal tumor changes between centers. In cases that the initial procedure was lobectomy, most clinicians would suggest for completion thyroidectomy since the risk of PTC in the contralateral lobe is significant. This study aimed to evaluate the incidence of bilateral involvement, predictive factors for bilaterality and whether or not bilaterality was related with more aggressive hi...