Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep1100 | Late Breaking | ECE2023

Diabetes mellitus secondary to BRCA2 gene mutation: the importance of insulin resistance and genetics in dysglycemia

Lopes Valentim , Brito Patricia , Machado Catarina , De Sousa Lages Adriana

Introduction: Diabetes mellitus (DM) results from a defect in insulin secretion and/or its action. The Breast-Cancer Susceptibility Gene 2 (BRCA2), like BRCA1, is a tumour suppressor gene, and its mutation is associated with an increased risk of breast cancer and, in males, testicular cancer. In patients with the BRCA1/2 mutation, the level of Insulin-like Growth Factor (IGF)-1 and, consequently, the peripheral sensitivity to insulin are reduced, suggesting that this ...

ea0041ep446 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Microbiological profile in diabetic foot infections: identification and susceptibility profile of bacteria isolated in 5 years in a Portuguese tertiary care hospital

de Sousa Lages Adriana , Oliveira Patricia , Costa e Silva Nuno , Guelho Daniela , Cardoso Luis , Vicente Nuno , Martins Diana , Oliveira Diana , Ventura Mara , Carrilho Francisco

Introduction: The diagnosis of infected ulcer is mainly clinical. The goals of the microbiological studies are identification of the pathogen and evaluation of susceptibility to antibiotics to minimize exposure to drugs and selection of resistant strains.Methods: Retrospective cohort study; Data collection: 1 January 2010 to 31 December 2014. Were included wound samples of aspirate, nonsurgical/surgical exudate, pus from abscesses and bone fragments from...

ea0041ep511 | Diabetes complications | ECE2016

Clinical factors and severity of diabetic foot infection according to the PEDIS classification

de Sousa Lages Adriana , Oliveira Patricia , Queiros Susana , Guelho Daniela , Cardoso Luis , Vicente Nuno , Martins Diana , Oliveira Diana , Ventura Mara , Carrilho Franscisco

Introduction: The complications related to ulcerated foot lesions are a common cause of hospitalization among diabetics. Diabetic foot infection is associated with high morbidity and is the most common precipitating factor to precede amputations of the lower limbs.Methods: Retrospective, cohort study; were included 200 patients from the Diabetic Foot consultation of the Endocrinology Department between 1 January and 31 August 2015. Ulcerated lesions were...

ea0056p401 | Diabetes (to include epidemiology, pathophysiology) | ECE2018

Glycemic variability and diabetes-related antibodies titer at diagnose in type 1 diabetic patients: is there a correlation?

De Sousa Lages Adriana , Cardoso Luis , Baptista Carla , Barros Luisa , Oliveira Patricia , Oliveira Diana , Ventura Mara , Cunha Nelson , Catarino Diana , Fadiga Lucia , Carrilho Francisco

Introduction: Type 1 Diabetes (DM1) is associated with a destructive autoimmune process of pancreatic b-cells. The presence of anti-islet cells (ICA) antibodies (Ab), as well as for distinctive antigens – GAD65, IA2 or Insulin (IAA) - is related to the disease development.Aim: To evaluate the effect of DM1 antibodies on the measures of glycemic variability (GV) obtain through continuous glucose monitoring (CGM).Materials and m...