Searchable abstracts of presentations at key conferences in endocrinology

ea0014p286 | (1) | ECE2007

An analysis on delays in diagnosis of papillary thyroid cancer

Dionigi Gianlorenzo , Dionigi Renzo , Bartalena Luigi , Tanda Maria Laura , Piantanida Eliana , Boni Luigi , Rovera Francesca

Background: Thyroid carcinoma represents the most frequent form of cancer of the endocrine glands. In Italy, temporal trend shows a significant increase of incidence rates. Papillary thyroid cancer is the most common thyroid malignancy. Papillary thyroid carcinoma happens to be a multicentric tumor and trends to spread to the lymph nodes in the early stage of the disease. Thus early diagnosis is vital to improve the outcome for patients with thyroid cancer. The aim of this stu...

ea0092ps2-13-10 | Surgery | ETA2023

Transoral robotic thyroidectomy for thyroid diseases - lessons learned from a 1000 consecutive procedures

Park Dawon , Yub Kim Hoon , Jung Kwang-Yoon , Dionigi Gianlorenzo

Background: To evaluate the technical feasibility, effectiveness, and safety of transoral robotic thyroidectomy (TORT), using the da Vinci system through analysis of our series of 1000 consecutive patients.Method: A review of a prospectively designed database at our institute from September 2012 to February 2022 revealed a series of 1000 consecutive TORT patients with preoperative diagnosis of various thyroid diseases. Clinicopathologic characteristics a...

ea0014p432 | (1) | ECE2007

Simultaneous occurrence of multicentric medullary and papillary thyroid cancer: a case report

Dionigi Gianlorenzo , Castano Patrizia , Bertolini Valentina , Tanda Maria Laura , Bartalena Luigi

Background: Papillary thyroid cancer is a well-differentiated neoplasm and is the most common, accounting for 65–85% of all thyroid cancer. On the other hand, medullary carcinoma represents only 3–12%. The concurrence of distinct medullary and papillary carcinoma within the same thyroid has been sporadically described.Case presentation: We report a rare case of simultaneous sporadic both multicentric medullary and papillary thyroid cancer with ...

ea0014p434 | (1) | ECE2007

Amyloid goitre: report of a case

Dionigi Gianlorenzo , Salvadore Maurizio , Tanda Maria Laura , Piantanida Eliana , Villa Francesca

Background: Amyloidosis is an important etiological factor of end stage renal disease. Apart from major target organs as cardiovascular, respiratory and gastrointestinal system, endocrine organs can also be involved. Amyloid goitre was described for the first time by Beckmann in 1858. Approximately 200 cases of amyloid goiter have been reported in English literature.Case presentation: The patient is a 67-year-old woman. The patient referred in 1989 the p...

ea0092op-03-01 | Oral Session 3: Signalling in Thyroid cancer | ETA2023

Patient-Derived in vitro models for unraveling medullary thyroid cancer microenvironment and therapy resistance

Stellaria Grassi Elisa , Ghiandai Viola , Cirello Valentina , Gazzano Giacomo , Dionigi Gianlorenzo , Persani Luca , Fugazzola Laura

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor arising from parafollicular C-cells. Nowadays different targeted therapies are available, directed mostly against the main genetic driver of MTC, RET, and against the common pro-oncogenic pathways of VEGF, EGFR and c-MYC. Despite this, an escape phenomenon has been observed with sudden disease progression during treatment, leaving surgery as the only curative treatment. The evaluation of pre and post treatment ge...

ea0081p217 | Thyroid | ECE2022

A combining pre-surgical thyroid risk score (TRS) for nodules with indeterminate cytology

Colombo Carla , Vannucchi Guia , Muzza Marina , Pogliaghi Gabriele , Palazzo Sonia , Dionigi Gianlorenzo , Persani Luca , Gazzano Giacomo , Fugazzola Laura

Background: Cytology is the gold standard method for the differential diagnosis of thyroid nodules, though 25−30% of them are classified as indeterminate and, in some cases, surgery is required for a definitive diagnosis. Aim: In order to reduce unnecessary thyroid surgeries, we set up a ‘thyroid risk score’ (TRS) to increase the diagnostic accuracy in a large series of patients with indeterminate cytology and to apply it to a validation ...

ea0092ps1-04-07 | Nodules-surgery | ETA2023

Completion thyroidectomy via robotic transoral vestibular approach - preliminary outcome report

Park Dawon , Yub Kim Hoon , Jung Kwang-Yoon , Baek Seung-Kuk , Jin Kim Kyeong , Russell Jon , Dionigi Gianlorenzo

Introduction: Transoral Robotic Thyroidectomy (TORT) is progressively gaining its ground in robotic thyroid surgery. With accumulated techniques and developments, TORT can also be applied for completion thyroidectomy. We review our experience with the transoral robotic approach to completion thyroidectomy to evaluate the safety and surgical feasibility.Methods: Consecutive patients receiving completion TORT operation were evaluated from a prospective dat...

ea0049ep1451 | Thyroid (non-cancer) | ECE2017

Comparative analysis of clinicopathological characteristics between Korean and Italian thyroid cancer patients

An Jee Hyun , Kim Sin Gon , Kim Hoon Yub , Jung Kwang Yoon , Chae Yang Seok , Dionigi Gianlorenzo , Rausei Stefano , Tanda Maria Laura , Piantanida Eliana , Rosa Stefano La

Background: The incidence of thyroid cancer in South Korea has increased rapidly. Increase in medical surveillance and access to health care services have enhanced the detection of asymptomatic tumors. We investigated the differences of tumor characteristics between South Korean patients and Northern Italian patients subject to different healthcare systems.Methods: The demographic, histopathologic and management features of thyroid cancer operated in two...

ea0049ep688 | Obesity | ECE2017

Demographic and baseline characteristics of an obese population admitted for bariatric surgery in a secondary care centre

Gallo Daniela , Ippolito Silvia , Veronesi Giovanni , Dozio Eugenia , Frattini Francesco , Trotti Eugenia , Lai Adriana , Sassi Lorenza , Sabatino Jessica , Masiello Elvira , Premoli Paola , Bianconi Eleonora , Cusini Claudio , Rosetti Sara , Tanda Maria Laura , Dionigi Gianlorenzo , Bartalena Luigi , Piantanida Eliana

Obesity has become one of the greatest public health concerns and is known to be a major risk factor for cardiac, respiratory and metabolic diseases. Bariatric surgery is the most effective treatment for morbid obesity. According with guidelines, surgery is indicated for treatment of patients with BMI greater than 40 kg/m2 or above 35 kg/m2, with at least one obesity-related comorbid condition, such as as type 2 diabetes, hypertension, dyslipidemia, sleep...

ea0049ep691 | Obesity | ECE2017

Metabolic profile reversal after bariatric surgery

Gallo Daniela , Ippolito Silvia , Veronesi Giovanni , Dozio Eugenia , Frattini Francesco , Trotti Eugenia , Lai Adriana , Sassi Lorenza , Sabatino Jessica , Masiello Elvira , Premoli Paola , Bianconi Eleonora , Rosetti Sara , Cusini Claudio , Laura Tanda Maria , Dionigi Gianlorenzo , Bartalena Luigi , Piantanida Eliana

Bariatric surgery is the most-effective treatment for morbid obesity, superior to medical treatment. Metabolic syndrome (MS) is a condition characterized by multiple major risk factors for coronary heart disease, diabetes, fatty liver, and several cancers; the main, diagnostic, components of MS are low HDL-cholesterol (<40 mg/dl in man, <50 mg/dl in woman), raised triglycerides (>150 mg/dl), blood pressure >130/85 mmHg, fasting plasma glucose >100 mg/dl and...