Endocrine Abstracts

Objective: To evaluate the presence of glucose metabolism abnormalities and their impact on IGF-1 levels in patients with acromegaly.Methods: Ninety-three acromegalic patients (52 male/41 female) were included in this study who were seperated into three groups as normal glucose tolerance (NGT), prediabetes and diabetes mellitus (DM). Insulin resistance (IR) was calculated with homeostasis model assessment (HOMA). HOMA-IR >2.5 or ≤2.5 were defin...

Purpose: Tumor-associated protein called as anterior gradient 2 (AGR2), which is defined particularly in breast and lung carcinomas, is involved in a variety of cellular functions such as cell migration, differentiation and proliferation. Since the role of AGR2 expression in pituitary adenomas is not well known yet, it was aimed to compare AGR2 expression in normal pituitary tissue and pituitary adenoma specimens in the study.Material and Method: We incl...

Idiopathic granulomatoushypophysitis is a rare inflammatory disease which is characterized by inflammation and cellular infiltration of the pituitary gland. The infiltration may cause pituitary insufficiency, compression symptoms due to mass effect and diabetes insipidus. We report the case of a 33-year-old female patient who presenting with weakness, fatigue, amenorrhea and worsening of headaches about 3 months. The patient did not have blurring vision and polyuria-polydipsia...

Purpose: Somatotrophinomas have been shown to demonstrate T2-weighted signal intensity (WSI) on MRI that is correlated with clinicopathological findings and response to treatment. Therefore, we aimed to investigate these correlations in functional pituitary adenomas, including prolactinoma and corticotrophinoma. Material and MethodsPatients with somatotrophinoma (n=87), prolactinoma (n=78) and corticotrophinoma (n=33) were invo...

Introduction: Congenital adrenal hyperplasia (CAH) due to 11 beta-hydroxylase deficiency (11βOHD) is a rare autosomal recessive genetic disorder. It results defects in adrenal cortisol and aldosterone synthesis. Early diagnosis and initiation of treatment in male patients are essential in order to prevent serious complications. We report a male patient with CAH who developed complications because of late diagnosisCase Report: 44-year-old male patien...

Introduction: Isolated bone metastasis of endometrium carcinoma is rare; but if it occurs, pelvis and vertebrae are involved mostly. Co-existence of undiagnosed Paget’s disease in a patient with malignancy causes major problems in differential diagnosis.Case: A 77 year-old woman was admitted to our hospital with severe pelvic pain. She had been diagnosed with inoperable endometrium adenocarcinoma for over a year. Metastatic bone disease was suspecte...

AimTo examine and compare the anxiety level and stress perception of acromegaly patients with controlled and active disease in the COVID-19 pandemic.Material and Method49 (23 females/26 males) patients admitted to the outpatient clinic during the first month after the pandemic period were recruited in this cross-sectional study. State-Trait Anxiety Inventory (S-Anxiety for state scale, T-Anxiety for trait sca...

ObjectiveTo evaluate the effects of the pandemic process on those with an endocrinological disease that will require close follow-up from the last visit before the pandemic.DesignThis was a retrospective study.MethodsPatients of 3903 with thyroid, calcium-bone metabolism, adrenal gland, pituitary diseases, and neuroendocrine tumor (NET) were retrospectively scanne...

PurposeTo assess the depression and anxiety and their relationship with disease activity in patients with Cushing’s syndrome (CS) in the COVID-19 pandemic.Material and methodsThis is a cross-sectional study including 54 patients with CS (48 female/6 male). Beck Depression Inventory-II (BDI-II), State Trait Anxiety Inventory (STAI)-State, STAI-Trait were used to evaluate, scores and severity of depression...