Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep562 | Diabetes complications | ECE2017

Biomarkers status and their relation with the presence of type 2 diabetes with and without angiopathy

Valente Ana , Bicho Manuel , Duarte Rui , Raposo Joao , Costa Helena Soares

Introduction: A useful tool for disease clinical characterization and treatment of type 2 diabetes is the knowledge on the status of several biomarkers. The aim of this study was to evaluate the levels of cardiovascular, oxidative stress and nutritional biomarkers and their relationship with the presence of type 2 diabetes and angiopathy.Methods: A population-based case-control study in 150 Portuguese type 2 diabetic patients was performed. Group I &#150...

ea0037ep538 | Diabetes (complications & therapy) | ECE2015

Contribution of haptoglobin and MTHFR polymorphisms to hyperhomocysteinemia and hypercysteinemia in type 2 diabetic patients

Valente Ana , Bicho Manuel , Garcia Ana , Goncalves Conceicao , Duarte Rui , Raposo Joao F , Costa Helena S

Introduction: There is a lack of epidemiological data on the distribution of haptoglobin and C677T of MTHFR polymorphisms in Caucasians type 2 diabetic patients. The contribution of these two genetic factors to hyperhomocysteinemia and hypercysteinemia can be useful to prevent cardiovascular events and to reduce public health costs. The aim of this study is to evaluate the contribution of haptoglobin and C677T polymorphisms for hyperhomocysteinemia and hypercysteinemia in Port...

ea0016p218 | Diabetes and cardiovascular diseases | ECE2008

Diabetes management and metabolic control are below expectations in specialist diabetes practice in Portugal

Cardoso Salvador Massano , Duarte Rui , Boavida Jose Manuel , Manuela Carvalheiro , Davide Carvalho , Luis Gardete

In Portugal, no relevant epidemiologic data exists relative to the management and level of control of diabetic patients.TEDDI, a non-interventional cross-sectional study, allowed to characterize the usual management of type 1 (T1D) and type 2 (T2D) diabetes using a standardized questionnaire in 1775 patients (F: 47.5%; T2D: 80.8%) aged 18 years or older, visiting their diabetes specialist (n=180).Data was obtained for metabo...

ea0056p473 | Diabetes complications | ECE2018

The effect of glutathione S-transferase M1 and T1 polymorphisms on ascorbic acid plasma levels in diabetic patients

Valente Ana , Bicho Manuel , Carolina Santos Ana , Matos Andreia , Duarte Rui , Raposo Joao F , Costa Helena S

Introduction: Type 2 diabetes mellitus have been associated with excessive production of reactive oxygen species. Glutathione S-transferase (GST) polymorphisms result in decreased or absent enzyme activity and altered oxidative stress. Meta-analyses have indicated that deletion of either GSTM1 or GSTT1 is associated with a significant increased risk of coronary heart disease. The aim of this study was to evaluated if ascorbic acid (AA) plasma levels differ by GST genotype in d...