Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep482 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effect of laparoscopic mini-gastric bypass on the compensation of carbohydrate metabolism in patients with morbid obesity and type 2 diabetes

Mazurina Natalya , Ershova Ekaterina , Komshilova Kseniya , Kim Ekaterina

Objective: Sustained weight loss is a highly effective strategy to treat and prevent the development of type 2 diabetes (T2D). Bariatric surgery leads to significant weight loss, which ensures the achievement of remission of diabetes mellitus and other obesity-related comorbidities. AimThe aim of this study was to estimate glycemic profile of patients with morbid obesity and T2D after laparoscopic mini-gastric bypass (LMGB). MethodsWe conducted a retrospective study of ob...

ea0090ep583 | Endocrine-related Cancer | ECE2023

Recurrent parathyroid cancer in a child associated with mutation in CDC73 gene

Kim Ekaterina , Krupinova Julia , Eremkina Anna , Kalinchenko Natalya , Mokrysheva Natalia

Background: Parathyroid cancer (P?) in children is extremely rare, more often sporadic, but may be associated with a germline mutation. The only effective treatment is surgical approach due to the chemo-radio-resistance of PC.Clinical case: A 6-years-old girl presented with weakness, gait disturbance, pain in the limbs, an X-shaped curvature of the legs. At the age of 12, the patientÂ’s well-being worsened sharply. The laboratory examination revealed...

ea0099ep1258 | Late Breaking | ECE2024

Atypical manifestation of parathyroid carcinoma in patient with RET and CYP24A1 mutations: a case report

Asanova Aurika , Kim Ekaterina , Eremkina Anna , Pigarova Ekaterina , Mokrysheva Natalia

Introduction: Parathyroid carcinoma (PC) is one of the rarest endocrine malignancies. Most PCs are sporadic, sometimes occurring in the framework of familial primary hyperparathyroidism (PHPT). PHPT due to PC is usually characterized by significantly increased PTH levels, severe hypercalcemia, larger tumor size and a higher incidence of disease complications. Clinical case: A 56-year-old male C. presented with an accidental formation at the posterior con...

ea0090ep579 | Endocrine-related Cancer | ECE2023

Mathematical model for preoperative differential diagnosis for the parathyroid neoplasms

Krupinova Julia , Elfimova Alina , Kim Ekaterina , Eremkina Anna , Maganeva Irina , Kovaleva Elena , Mokrysheva Natalia

Backgrounds: Preoperative diagnosis of parathyroid carcinoma (PC) is critical for the determination of the scope of surgical intervention. Nowadays, specific diagnostic markers for differentiation of PC and benign tumors are unknown, and less than half of patients with PC undergo necessary en bloc surgery.Aims: To develop the instrument for preoperative diagnosis of PC.Materials and methods: A multi-center retrospective study inclu...

ea0090ep586 | Endocrine-related Cancer | ECE2023

Parathyroid carcinoma in a patient with both MEN1 and RET mutations

Pylina Svetlana , Kim Ekaterina , Bondarenko Ekaterina , Krupinova Julia , Eremkina Anna , Mokrysheva Natalia

Background: MEN1-related primary hyperparathyroidism (PHPT) characterised by benign course, whereas malignant transformation is extremely rare. The diagnosis of parathyroid carcinoma (PC) within the MEN-1 syndrome is a challenge for a range of specialists.Clinical case: A 47-year Eastern European female. PHPT had been revealed during examination for multinodular goitre: PTH 614 nmol\l, calcium 3.06 mmol\l. Results of imaging methods were controversial (m...

ea0099p180 | Late-Breaking | ECE2024

Immunohistochemistry in the differential diagnosis of atypical tumor and parathyroid carcinoma

Kim Ekaterina , Lavreniuk Anastasiia , Elfimova Alina , Eremkina Anna , Selivanova Lilia , Salimkhanov Rustam , Mokrysheva Natalia

Background: Atypical parathyroid tumor (APT) generally has a better prognosis compared to parathyroid carcinoma (PC). The differential diagnosis of APT and PC is crucial for further management. Diagnosis of both is based on morphological examination but sometimes can be challenging. In such cases immunohistochemistry (IHC) should be used.Objective: To estimate the utility of IHC in the differential diagnosis of APT and PC.Materials...

ea0099p190 | Late-Breaking | ECE2024

Severe osteoporosis in a patient with APECED: atypical presentation

Lavreniuk Anastasiia , Kim Ekaterina , Salimkhanov Rustam , Eremkina Anna , Spasskaya Olga , Mokrysheva Natalia

Hypoparathyroidism (HPT) is the most common autoimmune endocrine involvement of APECED syndrome (autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, 79-96% cases). HPT is associated with reduced bone remodeling, abnormalities in microarchitecture and bone strength, thus low-energy fractures occur despite normal or even high bone mineral density (BMD). Other APECED components (hypogonadism, malabsorption, growth hormone deficiency etc.), may also affect bone metabol...

ea0099ep1234 | Late Breaking | ECE2024

Patient with MEN1 gene deletion and the classic triad of MEN-1 components

Salimkhanov Rustam , Vishnyakova Victoria , Kim Ekaterina , Lavreniuk Anastasia , Eremkina Anna , Vizerov Timofei , Utkina Marina , Mokrysheva Natalia

Introduction: Multiple endocrine neoplasia syndrome type 1 (MEN-1) is an autosomal dominant disorder caused by germline mutations in the MEN1 gene encoding menin. MEN1 mutations are mainly represented by deletions/insertions, nonsense, splice site or missense mutations and can be detected by DNA sequencing. MEN-1 generally includes parathyroid, adenohypophysis, and pancreatoduodenal neuroendocrine tumors.Clinical Case: Patient S., 26-ye...

ea0099ep1237 | Late Breaking | ECE2024

Therapeutic options in the control of refractory hypercalcemia due recurrent parathyroid carcinoma: a case series

Spasskaya Olga , Kim Ekaterina , Salimkhanov Rustam , Lavreniuk Anastasiia , Eremkina Anna , Mokrysheva Natalia

Introduction: Parathyroid carcinoma (PC) is one of the rarest malignant endocrine neoplasms (0.005% of all oncological diseases). PC relapses in 40-60% cases. The severity of the disease is determined by life-threatening hypercalcemia. Surgery is the gold treatment standard of primary tumors and distant metastases, but if it is contraindicated there are few options to control life-threatening hypercalcemia.Case 1: A 36-year-old-woman with a recurrent par...

ea0090ep584 | Endocrine-related Cancer | ECE2023

Patient-derived three-dimensional model of papillary thyroid cancer for personalized medicine and testing of novel therapies

Petrova Daria , Bastrich Asya , Abilov Zaur , Bondarenko Ekaterina , Urusova Liliya , Nikiforovich Petr , Belcevich Dmitry , Pylina Svetlana , Eremkina Anna , Kim Ekaterina , Mokrysheva Natalia

Introduction: Over the last decades, there has been a significant increase in the incidence of thyroid cancer. Papillary thyroid cancer (PTC) is the most common histopathological type with often a favorable prognosis. Conventional therapies include surgical resection, adjuvant therapy with radioactive iodine, and suppressive therapy with thyroid hormones. However, the prognosis for iodine-resistant/refractory thyroid cancers or the advanced metastatic cancer is less favorable....