Searchable abstracts of presentations at key conferences in endocrinology

ea0035p889 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Acromegalic arthropathy: clinical presentation, treatment and quality of life

Nunes Joana Menezes , Rodrigues Elisabete , Carvalho Davide

Introduction: Arthropathy affects the majority of acromegalic patients and is a major cause of morbidity, absenteeism and impaired quality of life. GH excess and increased levels of circulating IGFI result initially in a marked thickening of the soft tissues and cartilage. Along with disease progression, there’s subperiostal bone neoapposition, cartilage regressive phenomena and bone structural changes. We aimed to investigate prevalence, clinical presentation, treatment ...

ea0032p128 | Calcium and Vitamin D metabolism | ECE2013

Late-onset hypoparathyroidism 15 years after thyroidectomy

Nunes Joana Menezes , Rodrigues Elisabete , Carvalho Davide

Introduction: Post-surgical hypoparathyroidism is a well known complication of total thyroidectomy. It may occur as transitory hypoparathyroidism that spontaneously recover within a few weeks/months and as permanent hypoparathyroidism needing long-term treatment. Only few cases of hypoparathyroidism newly diagnosed many years after surgery have been reported. We present a patient with hypoparathyroidism that became clinically evident 15 years after the thyroid surgery.<p c...

ea0049ep305 | Calcium &amp; Vitamin D metabolism | ECE2017

Pseudohypoparathyroidism (PHP) and GNAS gene mutations – clinical spectrum from PHP type 1a to pseudopseudohypoparathyroidism

Saavedra Ana , Rodrigues Elisabete , Cunha Filipe , Leao Miguel , Carvalho Davide

Introduction: Pseudohypoparathyroidism (PHP) refers to a heterogeneous group of disorders that have in common end-organ unresponsiveness to parathyroid hormone (PTH). The most frequent form, PHP type 1, results from different genetic/epigenetic changes in the GNAS gene.Case 1: Woman, 25 years-old, sent to Endocrinology from Genetics consultation after her daughter had been diagnosed with PHP type 1a (heterozygous pathogenic variant at exon 13 of...

ea0049ep1206 | Clinical case reports - Thyroid/Others | ECE2017

Amyloid goiter secondary to Crohn’s disease

Saavedra Ana , Rodrigues Elisabete , Marques Ana , Carvalho Davide

Introduction: Amyloidosis results from deposition of insoluble proteins in the extracellular space. It can be both primary or secondary to chronic inflammatory diseases. Although microscopic thyroid involvement is common, cases in which it becomes clinically evident (amyloid goiter) are rare.Case report: Woman, 45 years. In 2009, she was diagnosed with Crohn’s disease after Bartholin’s gland abscess excision and evaluation for weight loss, anem...

ea0041ep722 | Male Reproduction | ECE2016

Hypogonadotropic hypogonadism – clinical spectrum: from sporadic to familiar forms

Saavedra Ana , Rodrigues Elisabete , Lemos Manuel , Carvalho Davide

Introduction: Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder. It can be sporadic or familiar and is divided into anosmic hypogonadotropic hypogonadism (Kallmann syndrome - KS) and congenital normosmic isolated hypogonadotropic hypogonadism (idiopathic hypogonadotropic hypogonadism &hyphen; IHH). A growing number of genes are involved in its etiology, suggesting the heterogeneity and complexity of this condition.Cases Reports: Six cases...

ea0037ep545 | Obesity and cardiovascular endocrinology | ECE2015

Calculating serum LDL cholesterol (LDL-C): comparison of LDL-C measured by direct assay with various formulae by combination of ages, genders, and triglycerides

Nunes Joana Menezes , Rodrigues Elisabete , Carvalho Davide , Guimaraes Joao Tiago

Introduction: LDL cholesterol (LDL-C) is a major risk factor for atherosclerosis. The Friedewald formula (FF) is limited by hypertriglyceridaemia. We aimed to correlate serum LDL-C measured by direct assay with serum LDL-C estimated by several formulas: Friedewald (FF): LDL-C=CT-HDL−TG/5; Tsai (TsaiF): LDL-C=TC-HDL−TG/8 (TG/8 represents very-LDL-C); DeLong (DeLongF): LDL-C=TC-HDL−TG×0.16 and Chen (ChenF): LDL-C=non-HDL-cholesterol×0.9−TG×...

ea0037ep1263 | Clinical Cases–Thyroid/Other | ECE2015

Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goitre

Cunha Filipe , Rodrigues Elisabete , Oliveira Joana , Vinhas Luis , Carvalho Davide

Introduction: Thyrotoxicosis after total thyroidectomy (TT) is mostly iatrogenic. Rarely, an hyperfunctional thyroid remnant or ectopic tissue may be the cause. We report a case of Graves’s disease in a mediastinal thyroid mass presenting 7 years after TT for nontoxic goitre.Case report: A 67-year-old woman presented with palpitations, fatigue and weight loss. She had a history of TT for nontoxic multinodular goitre at the age of 60 without any sign...

ea0081p538 | Adrenal and Cardiovascular Endocrinology | ECE2022

Primary adrenal angiosarcoma within a hematoma

Rodrigues Elisabete , Oimenta Tiago , Pinheiro Jorge , Carvalho Davide , Manuel Lopes Jose

Introduction: Angiosarcomas account for < 1% of all sarcomas, and are highly agressive neoplasms whose clinical course is striking: local recurrence, metastasis, and a high mortality rate. Primary angiosarcoma of the adrenal gland was first described in 1988 by Kareti et al. and is very rare with, so far, only 51 reported cases. Case report: A 49-year-old male, without prior malignancy, presented with a 4.9x5.9 cm right adrenal nodule and a 2.4 cm le...

ea0037ep1299 | Clinical Cases–Thyroid/Other | ECE2015

Graves' orbitopathy coursing with hypothyroidism: a case-report

Saavedra Ana , Nunes Joana Menezes , Rodrigues Elisabete , Ribeiro Sara , Leal Victor , Carvalho Davide

Introduction: Graves’ orbitopathy is usually associated with Graves’ Disease, which is typically characterized by hyperthyroidism and goiter. However, in rare situations, Graves’ disease can also present with hypothyroidism and orbitopathy.Case report: Male, 38 years old, followed by his ophthalmologist for thyroid orbitopathy (exophthalmos right>left and conjunctival hyperaemia since 1 year ago) associated with asthenia, tiredness and...

ea0022p862 | Thyroid | ECE2010

Clinical and histopathologial characteristics of papillary thyroid microcarcinoma (PTMC)

Rodrigues Elisabete , Sousa Ana , Lima Luis Matos , Pimenta Amadeu , Medina Jose Luis

Introduction: The recognition of thyroid microcarcinoma has been increasing in recent years probably as a result of the widespread use of ultrasound-guided fine-needle aspiration biopsies (FNAB) of small non palpable nodules and possibly of a more extensive histological examination.Objectives: To describe clinical and histological characteristics of papillary thyroid microcarcinoma and compare them according to its size (< or ≥5 mm).<p clas...