Endocrine Abstracts

Aim: The primary objective of this study was to evaluate the structural and functional cardiac parameters with MRI in patients with primary hyperparathyroidism (pHPT) before and after successful surgery.Method: In this prospective study 16 patients with pHPT were included. Detailed cardiac magnetic resonance imaging (MRI) examinations were performed preoperatively and at six months post-surgery. Following parameters were measured: Left ventricle ejection...

Introduction: 3-Iodothyronamine (T1AM) is a novel endogenous relative of thyroid hormone able to interact with specific G protein-coupled receptors, known as trace amine-associated receptors (TAAR). Metabolic, endocrine and cardiac effects of exogenous T1AM have been reported.Methods: We synthesized radiolabelled T1AM, [125I]-T1AM, and explored its distribution in different mouse organs after injection in the tail vein. The specificity of [<su...

Effective targeted therapy for advanced endocrine malignancies is a goal of modern endocrinology. We herein present promising results of the first phase of clinical part of European project (Gran-T-MTC) aimed to assess the safety of gastrin analogue CP04 (DOTA-(DGlu)6-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2) i.v. administration in dose (50 μg) useful for translation to 177In-CP04 for PRRT. CP04 has been selected for MTC therapy based on a high CCK-2 receptor...