Searchable abstracts of presentations at key conferences in endocrinology

ea0041mte10 | (1) | ECE2016

Systems medicine: the impact on endocrine practice

Resmini Eugenia

Systems Medicine is an interdisciplinary field of study that deals with systems of the human body as part of an integrated whole, incorporating biochemical, physiological, and environment interactions. Systems Medicine draws on systems science and systems biology, and considers complex interactions within the human body with a patient’s genomics, behavior and environment perspective. The earliest uses of the term systems medicine appeared in 1992, it is a modern approach ...

ea0063p500 | Calcium and Bone 2 | ECE2019

Body mass index is a biomarker of resistance to active vitamin D but not to calcium supplementation, in patients with hypoparathyroidism

Tecilazich Francesco , Formenti Anna Maria , Frara Stefano , Resmini Eugenia , Doga Mauro , Giubbini Raffaele , Giustina Andrea

Background: Persistent Hypoparathyroidism (PH) is a condition characterized by inappropriately low concentrations of PTH that lead to hypocalcemia. The treatment cornerstones of PH are calcium and calcitriol supplementation; however, several patients do not achieve adequate control of the disease under this conventional therapy. Notably, no biomarker of risk of ‘resistance’ has yet been identified. Based on the fact that obesity alters the vitamin D-calcium homeostas...

ea0041ep17 | Adrenal cortex (to include Cushing's) | ECE2016

Psychopathology, memory and quality of life in Cushing’s syndrome

Santos Alicia , Resmini Eugenia , Crespo Iris , Valassi Elena , Martinez Maria Antonia , Pires Patricia , Webb Susan

Introduction: Cushing’s syndrome (CS) has been related to higher psychopathology. Psychopathology can be related to poor memory performance, and low quality of life. The aim of this study is to establish the relationship between the three parameters and with subjective symptom perception in CS.Methods/design: Thirty six patients in remission of CS and 36 matched controls for age, sex and education years were included in the study. They completed SCL...

ea0037gp.02.06 | Adrenal (1) | ECE2015

DNA methylation of FKBP5 and its relationship with hippocampal volumes in Cushing's syndrome patients

Resmini Eugenia , Santos Alicia , Aulinas Anna , Webb Susan , Gomez-Anson Beatriz , Cox Olivia , Lee Richard

Introduction: FKBP5 is a protein that regulates glucocorticoid receptor sensitivity, via an ultra-short negative feedback mechanism. Variations in the FKBP5 gene can influence the response to glucocorticoids (GC). Hypercortisolaemia plays a role on impairment of brain function and could be mediated by epigenetic variations of the FKBP5 gene. Cushing’s syndrome (CS), a disease characterized by hypercortisolaemia, is associated with memory deficits, lower ...

ea0070ep292 | Pituitary and Neuroendocrinology | ECE2020

Quality of life in patients with Cushing’s syndrome in remission: 10-year follow-up

Santos Alicia , Resmini Eugenia , Martinez Momblan Mª Antonia , Medina Marc , Webb Susan

Introduction: Cushing’s syndrome (CS) has been associated with low quality of life, even after biochemical cure. However little data is available on long term follow-up. The aim of the study was to analyse 10-year follow-up of quality of life (QoL) in patients in remission of CS.Methods: 24 patients in remission of CS followed in Hospital Sant Pau were included in this study (3 men, 21 pituitary origin, 3 adrenal; mean baseline age 45.1 ± 14.1...

ea0014p527 | (1) | ECE2007

Prolonged orocecal transit time and small intestinal bacterial overgrowth in acromegalic patients

Resmini Eugenia , Parodi Andrea , Savarino Vincenzo , Greco Alfredo , Rebora Alberto , Minuto Francesco , Ferone Diego

Gastrointestinal abnormalities in acromegaly include dolichomegacolon and increased prevalence of colonic polyps. No data are available on the small intestine. The aims of this study were to investigate orocecal transit time (OCTT) and the presence of small intestinal bacterial overgrowth (SIBO) in acromegaly. 41 acromegalic patients and 30 controls entered the study. Acromegalics were classified according to whether they were on medical treatment with somatostatin analogs (SS...

ea0056p852 | Pituitary - Clinical | ECE2018

Psychopathology in Cushing’s disease and acromegaly

Santos Alicia , Resmini Eugenia , Crespo Iris , Valassi Elena , Martinez Ma Antonia , Webb Susan M

Introduction: Cushing’s disease (CD) and acromegaly, despite their different specific symptoms, often present psychopathology (mainly depression and anxiety) even after hormonal normalization. However, their psychopathological profiles may be different. The aim of this study was to analyse the psychopathological profile in successfully treated Acromegaly and CD, and to compare both diseases. Current hormonal evaluation and time since endocrine control will also be analyse...

ea0063p1095 | Pituitary and Neuroendocrinology 3 | ECE2019

Poor response to pre-surgical treatment with Somatostatin Receptor Ligands is associated with diabetes in patients with acromegaly

Tecilazich Francesco , Frara Stefano , Losa Marco , Formenti Anna Maria , Resmini Eugenia , Doga Mauro , Mortini Pietro , Giustina Andrea

Purpose: To evaluate whether the degree of response to surgical pre-treatment with somatostatin receptor ligands (SRL) predicts alterations in blood glucose levels.Patients and methods: We retrospectively studied 181 patients attending the Unit of Neurosurgery of our Hospital prior to transsphenoidal surgery. All patients had a diagnosis of acromegaly (nadir GH during OGTT >0.4 ng/ml; and IGF-I above age-standardized UNL); diagnosis of diabetes (DM) ...

ea0037ep64 | Adrenal cortex | ECE2015

Serum brain-derived neurotrophic factor in Cushing's syndrome patients

Santos Alicia , Resmini Eugenia , Barahona Ma Jose , Crespo Iris , Valassi Elena , Martinez Ma Antonia , Marin Ana , Webb Susan M

Introduction: Brain-derived neurotrophic factor (BDNF) is a protein that has been linked to several cardiovascular risk factors and bone status. Stress and corticosteroid exposure can affect BDNF levels, although this has never been studied in Cushing’s syndrome (CS). The aims of this study were to establish if BDNF levels were reduced in CS and to check possible associations to cardiovascular risk factors and bone status.Methods: 52 patients (18 ac...

ea0070aep592 | Pituitary and Neuroendocrinology | ECE2020

Morphometric vertebral fractures are highly prevalent in patients with non-functioning pituitary adenoma and related to older age and hypopituitarism

Frara Stefano , Di Filippo Luigi , Doga Mauro , Maria Formenti Anna , Losa Marco , Resmini Eugenia , Tecilazich Francesco , Mortini Pietro , Giustina Andrea

Introduction: Recent studies showed that morphometric vertebral fractures (VF) are an early and frequent complication in patients (pts) withhyperfunctioning pituitary adenomas and hypopituitarism (independently from the etiology). GH excess or severe deficiency play a negative key role on bone health in this clinical setting. Disease control or adequate replacement therapies still remain a cornerstone for the clinician to reduce the burden of osteo-metabolic complications. To ...