Searchable abstracts of presentations at key conferences in endocrinology

ea0081p640 | Endocrine-Related Cancer | ECE2022

Short fasting test as reliable and effective tool to diagnose insulinoma

Mikovic Nevena , Zamponi Virginia , Mazzilli Rossella , Russo Flaminia , fazzalari beatrice , Faggiano Antongiulio

Introduction: Insulinomas are rare pancreatic NETs presenting with chronic hypoglycaemia. Current guidelines for diagnosis require a prolonged fasting test (72 h), which implies hospitalization and is difficult to perform, delaying prompt diagnosis and treatment. It has been reported that 65 to 85% of insulinomas could be diagnosed after less of a 24h fasting period and 94 to 95.7% within 48h, although a shorter test for diagnosis has not yet been standardized.<p class="ab...

ea0070aep622 | Pituitary and Neuroendocrinology | ECE2020

Sporadic neuroendocrine neoplasms in young-adult patients: Differences in natural history, prognosis and treatment compared to adult-elderly patients

Altieri Barbara , Modica Roberta , Bottiglieri Filomena , de Cicco Federica , Faggiano Antongiulio , Colao Annamaria

Introduction: Sporadic neuroendocrine neoplasms (NEN) occur rarely in young-adult (YA) patients, with an estimated incidence is about 2.8 cases per million, and data specific to their epidemiology are limited. The aim of our study was to better characterize the natural history, prognosis and management of NEN in YA patients (≤ 35 years old) compared to adult-elderly (AE; >35 years old).Methods: A retrospective observational study including 204 ...

ea0070ep484 | Thyroid | ECE2020

Clinical presentation and prognosis of patients with medullary thyroid cancer

de Cicco Federica , Modica Roberta , Barba Livia , Bottiglieri Filomena , Minotta Roberto , Faggiano Antongiulio , Colao Annamaria

Medullary thyroid carcinoma (MTC) is a rare type of tumor that originates from parafollicular C-cells and accounts for 3–4% of all malignant thyroid neoplasms. MTC presents as sporadic (75–80%) or inherited tumors (20–25%). Hereditary MTC is part of multiple endocrine neoplasia type 2 (MEN2). Aim of the study was to describe clinical presentation, prognosis and therapy of sporadic MTC patients. Sixty-seven patients (pts) with histologically confirmed MTC refe...

ea0032s31.3 | Clinical impact of rare mutations in endocrinology | ECE2013

Genetic diagnosis of hereditary neuroendocrine syndrome in asyntomatic patients: clinical and prognostic implications

Faggiano Antongiulio , Ramundo Valeria , Marciello Francesca , Del Prete Michela , Marotta Vincenzo , Colao Annamaria

Neuroendocrine tumours (NETs) can be sporadic or can arise in complex hereditary endocrine disorders such as multiple endocrine neoplasias (MENs), familial paragangliomatosis (FPGLs), neurofibromatosis type 1 (NF1), von Hippel–Lindau disease (VHL), tuberous sclerosis (TSC). It has been estimated that hereditary NET occurrence varies with site of origin of the tumour, representing 5–30% of all cases of NET. These rates seems to be an underestimation and novel mutation...

ea0026p73 | Endocrine tumours and neoplasia | ECE2011

68Ga-DOTATATE PET shows a better diagnostic performance than octreoscan in patients with neuroendocrine tumors

Faggiano Antongiulio , Aloi Luigi , Caraco Corradina , Ramundo Valeria , Severino Rosa , Lombardi Gaetano , Colao Annamaria , Lastoria Secondo

Background and objective: 111In-DPTA-Octreotide (Octreoscan) has limited spatial resolution and a somewhat lower receptor affinity of the radiopeptide compared to DOTATATE, a novel somatostatin analogue, which can be radiolabelled with 68Ga and adapted for PET imaging, resulting in an increased spatial resolution. The aim of this study was to evaluate the diagnostic performance of 68Ga-DOTATATE PET in patients with NET and to compare this tecni...

ea0026p274 | Pituitary | ECE2011

Recent changes in clinical presentation and therapeutic approach in MEN1-related pituitary adenomas

Ramundo Valeria , Severino Rosa , Milone Francesco , Lombardi Gaetano , Colao Annamaria , Faggiano Antongiulio

Background and objective: Pituitary adenomas (PAs) affect about half of the patients with multiple endocrine neoplasia type 1 (MEN1); in the most of cases PA is a PRL-oma and generally more aggressive than the sporadic form. The aim of this study is to evaluate the recent changes in clinical presentation and therapeutic approach of MEN1-related PAs.Patients and methods: The study population included 17 patients with MEN1-related PA followed-up between 19...

ea0026p530 | Bone/calcium/Vitamin D | ECE2011

Recent changes in clinical presentation and therapeutic approach of primary hyperparathyroidism in MEN1 patients

Severino Rosa , Ramundo Valeria , Milone Francesco , Lombardi Gaetano , Colao Annamaria , Faggiano Antongiulio

Introduction and aim: Primary hyperparathyroidism (PHP) is the most frequent endocrine abnormality in MEN1 affecting about 100% of cases and inducing severe bone and kidney complications. Although surgery represents the only curative approach in MEN1 PHP, novel drugs are now available to effectively control PHP. The objective of this study was to show the recent changes in clinical presentation and therapeutic approach in MEN1-related PHP occurred in the last years.<p clas...

ea0022p406 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Clinical and prognostic implications of the genetic diagnosis of hereditary NET syndromes in asymptomatic patients

Faggiano Antongiulio , Ramundo Valeria , Milone Francesco , Severino Rosa , Lombardi Gaetano , Colao Annamaria

Context: Neuroendocrine tumors (NETs) are rare neoplasms, heterogeneous, with variable biological behaviour. NETs can be sporadic or they can arise in complex endocrine hereditary syndromes such as Multiple Endocrine Neoplasias (MEN), Familial Paragangliomatosis (FPGL), Neurofibromatosis type 1 (NF1), von Hippel-Lindau Disease (VHL), Tuberous Sclerosis (TSC) and Carney Complex (CC). By performing genetic screening, patients with hereditary NETs can be identified before the dev...

ea0014p383 | (1) | ECE2007

Efficacy and safety of radiofrequency thermal ablation in the treatment of thyroid nodules with pressure symptoms in elderly patients

Faggiano Antongiulio , Di Somma Carolina , Milone Francesco , Ramundo Valeria , Lombardi Gaetano , Coloa Annamaria , Spiezia Stefano

Background: Nodular goiter is one of the commonest endocrinopathy. Its incidence increases with age accounting for more than 50% of subjects older than 60 years. Elderly subjects more frequently suffer from pressure symptoms. Loco-regional treatments, like laser photocoagulation and percutaneous ethanol injection, are a potentially useful tool to treat TNs but their efficacy is still debated. Radiofrequency thermal ablation (RTA) has been applied to several benign and malignan...

ea0056p135 | Endocrine tumours and neoplasia | ECE2018

Multiple endocrine neoplasia type 1: a retrospective monocenter analysis of 73 cases

Modica Roberta , Lo Calzo Fabio , de Cicco Federica , Bottiglieri Filomena , Sciammarella Concetta , Colao Annamaria , Faggiano Antongiulio

Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome, affecting multiple endocrine glands whose natural history remains largely unknown. Aim of this study was to assess the epidemiological and clinical profile of MEN1 in a single center. Seventy-three MEN1 patients, belonging to 30 different families, referred at the NET Center of Naples, from 2000 to 2017, were evaluated. Male/female ratio was 0.73, mean age 43 years (range 10–86). Forty-six cases (64%) we...