Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep903 | Pituitary - Clinical | ECE2016

Acromegalic cardiomyopathy: echocardiographic and CMR analysis

Casara Alvise , Dassie Francesca , Battocchio Marialberta , Parolin Matteo , Martini Chiara , De Carlo Eugenio , Mioni Roberto , Famoso Giulia , Tona Francesco , Fallo Francesco , Vettor Roberto , Corbetti Francesco , Maffei Pietro

Introduction: Acromegalic cardiomyopathy is characterized by myocardial hypertrophy and interstitial myocardial fibrosis at biopsy. We studied left ventricular hypertrophy -LVH- through echocardiography (-ECHO- 2-D standard echocardiography and Doppler analysis) and cardiac magnetic resonance (CMR) analysis. Myocardial fibrosis was studied with late enhancement technique (LE) and extracellular volume technique (ECV) at CMR.Methods: 25 patients -pts- (13 ...

ea0063gp98 | Adrenal and Neuroendocrine - Basic | ECE2019

Methylation status and gene expression of steroidogenic enzymes in benign adrenocortical tumors

Di Dalmazi Guido , Morandi Luca , Rubin Beatrice , Pilon Catia , Asioli Sofia , Maffeis Valeria , Vicennati Valentina , Pagotto Uberto , Fallo Francesco

Background: DNA methylation has been recognized as a putative regulatory mechanism for CYP11B2 in primary hyperaldosteronism. We aimed to investigate the DNA methylation and the expression of a panel of genes encoding several enzymes involved in steroidogenesis in adrenocortical benign tumors.Methods: We collected a total of 60 adrenocortical tissues, including 9 non-functioning adrenal adenomas, 9 adenomas associated with autonomous cortisol se...

ea0063p256 | Pituitary and Neuroendocrinology 1 | ECE2019

Hyperglycemia and pasireotide lar in acromegaly: a study with continuous glucose monitoring

Russo Lucia , Mazzocut Sara , Dassie Francesca , Parolin Matteo , Martini Chiara , Carlo Eugenio De , Fallo Francesco , Mioni Roberto , Vettor Roberto , Maran Alberto , Maffei Pietro

Background: Pasireotide LAR is a multireceptor targeted somatostatin analogue that has been shown to obtain a better biochemical control of acromegaly. However, pasireotide LAR could induce hyperglycemia in acromegalic patients with higher baseline glucose values. The devices that can track interstitial glucose levels such as continuous glucose monitoring (CGM) could be a useful for studying the impact of SSA on patientsÂ’ glucose status.Aim: We aime...

ea0063p1101 | Pituitary and Neuroendocrinology 3 | ECE2019

Pegvisomant: daily versus non daily administration a single centre real life study

Dassie Francesca , Rosson Marco , Parolin Matteo , Russo Lucia , Mazzocut Sara , Martini Chiara , De Carlo Eugenio , Mioni Roberto , Fallo Francesco , Vettor Roberto , Maffei Pietro

Background: Pegvisomant (PEG) is a second line medical treatment for active acromegalic patients. PEG efficacy is between 61.5 and 92% and even if it is administered daily its long half-life suggests a possible use with a non-daily regime.Aim: We aim to compare acromegalic patients on daily PEG administration (DP) with patients on non-daily PEG administration (NDP).Methods: We studied 43 acromegalic patients under PEG treatment bet...

ea0070aep43 | Adrenal and Cardiovascular Endocrinology | ECE2020

CYP11B2 DNA methylation pattern is discordant in aldosterone-producing adenomas and in concurrent aldosterone-producing cell clusters

Di Dalmazi Guido , Morandi Luca , Rubin Beatrice , Pilon Catia , Maffeis Valeria , Asioli Sofia , Vicennati Valentina , Pagotto Uberto , Fassina Ambrogio , Fallo Francesco

Background: Previous studies have shown an association between low CYP11B2 DNA methylation levels and high CYP11B2 mRNA levels in aldosterone-producing adenoma (APA), suggesting that epigenetic mechanisms play a pivotal role for regulating CYP11B2 function in primary aldosteronism. It has been proposed that aldosterone-producing cell clusters (APCCs) may become a source of autonomous aldosterone production when evolving into APA.Aim: Our aim was to deter...