Endocrine Abstracts

Introduction: Milder forms of central hypothyroidism (CeH) are still challenging to diagnose due to absence of gold standards, wide variability of fT4 values and aspecificity of symptoms. We aimed to find diagnostic clues at diagnosis (pituitary lesion dimensions, other hormonal deficit) and during long-term follow-up, guiding the clinician to a precocious diagnosis of CeH.Study: 142 patients harbouring a pituitary adenoma with complete pituitary assessm...

Diagnosis of Central Hypothyroidism (CeH) is commonly given when FT4 concentrations are below the lower limit of normal range. A reduction in FT4 concentrations greater than 20% was proposed in ETA 2018 Guidelines as an unphysiological fluctuation indicating the onset of milder forms of CeH with FT4 still within the normal range. Similarly, TSH-index was proposed to quantify thyrotrope reserve, hence as a tool to detect patients at risk of CeH. Here we verified the performance...

Background: As of December 2019, the COVID-19 pandemic has spread rapidly, therefore Governments from all over the world promoted a strategy of social confinement through a general lockdown in order to contain it. During the months following its introduction, many studies reported a significant increase in the incidence of idiopathic central precocious puberty (CPP) throughout several countries, especially in girls.Purpose: The aim of our study was to co...

Background: Articular and psychological complications of acromegaly are known to impair patients’ quality of life (QoL). The aims of this study are: (1) to look for clinical predictors for the progression of the articular and psychological complications, (2) to evaluate the progression of these complications in relation to the activity of the acromegalic disease, and (3) to evaluate how these complications interact to impair the QoL.Material and Met...

Introduction: While searching for mechanisms contributing to the increased mortality of acromegaly, we have previously described an unexpected sympathoinhibition in newly diagnosed patients (Seravalle et al., Clin Endocrinol 77:262, 2012) and interpreted this finding as an adaptive phenomenon. It has also been shown that centrally administered somatostatin (SS) inhibits peripheral sympathetic outflow in rodents (Rettig et al., Am J Physiol 257:R588, 1989). Ba...

Background: primary empty sella (ES) represents a frequent finding (up to 35% of the general population). According to the literature, the prevalence of hypopituitarism in ES ranges between 19-52%. Data on the natural history of ES over a long time, especially in incidental ES, are still lacking and the management can be challenging.Objective: our primary aim was to assess in a large cohort of patients with ES the prevalence and determinants of hypopitui...