Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep754 | Pituitary and Neuroendocrinology | ECE2022

Early diagnostic tools in milder forms of central hypothyroidism in patients harbouring a pituitary adenoma: cross-sectional study on 142 patients from a single tertiary center

Galazzi Elena , Nicoli Federico , Carrara Silvia , Milan Chiara , Fatti Letizia Maria , Moro Mirella , Persani Luca

Introduction: Milder forms of central hypothyroidism (CeH) are still challenging to diagnose due to absence of gold standards, wide variability of fT4 values and aspecificity of symptoms. We aimed to find diagnostic clues at diagnosis (pituitary lesion dimensions, other hormonal deficit) and during long-term follow-up, guiding the clinician to a precocious diagnosis of CeH.Study: 142 patients harbouring a pituitary adenoma with complete pituitary assessm...

ea0090p143 | Pituitary and Neuroendocrinology | ECE2023

Role of fT4 and TSH-index fluctuations as early diagnostic tools in milder forms of central hypothyroidism: data from 221 patients with pituitary lesions from a single tertiary center

Carrara Silvia , Galazzi Elena , Nicoli Federico , Moro Mirella , Fatti Letizia , Cangiano Biagio , Persani Luca

Diagnosis of Central Hypothyroidism (CeH) is commonly given when FT4 concentrations are below the lower limit of normal range. A reduction in FT4 concentrations greater than 20% was proposed in ETA 2018 Guidelines as an unphysiological fluctuation indicating the onset of milder forms of CeH with FT4 still within the normal range. Similarly, TSH-index was proposed to quantify thyrotrope reserve, hence as a tool to detect patients at risk of CeH. Here we verified the performance...

ea0090p736 | Reproductive and Developmental Endocrinology | ECE2023

The Impact of Covid-19 Lockdown on Pubertal Onset in A Second Level Center

Goggi Giovanni , Moro Mirella , Chila Alessandro , Fatti Letizia , Cangiano Biagio , Federici SIlvia , Galazzi Elena , Carbone Erika , Soranna Davide , Vezzoli Valeria , Persani Luca , Bonomi Marco

Background: As of December 2019, the COVID-19 pandemic has spread rapidly, therefore Governments from all over the world promoted a strategy of social confinement through a general lockdown in order to contain it. During the months following its introduction, many studies reported a significant increase in the incidence of idiopathic central precocious puberty (CPP) throughout several countries, especially in girls.Purpose: The aim of our study was to co...

ea0099p390 | Late-Breaking | ECE2024

Progression of joint and psychological complications in acromegaly and their association with treatments and disease control

Cangiano Biagio , Premoli Caterina , Soranna Davide , Vitale Giovanni , Grottoli Silvia , Cambria Valeria , Maffei Pietro , Dassie Francesca , Cannavo Salvatore , Ragonese Marta , Zambon Antonella , Persani Luca , Fatti Letizia , Scacchi Massimo

Background: Articular and psychological complications of acromegaly are known to impair patientsÂ’ quality of life (QoL). The aims of this study are: (1) to look for clinical predictors for the progression of the articular and psychological complications, (2) to evaluate the progression of these complications in relation to the activity of the acromegalic disease, and (3) to evaluate how these complications interact to impair the QoL.Material and Met...

ea0032p865 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effects of somatostatin analogues on muscle sympathetic nerve activity in acromegaly

Carzaniga Chiara , Seravalle Gino , Attanasio Roberto , Grassi Guido , Cozzi Renato , Maria Fatti Letizia , Montini Marcella , Vitale Giovanni , Sciortino Giovanna , Damanti Sarah , Scacchi Massimo , Mancia Giuseppe , Cavagnini Francesco , Persani Luca

Introduction: While searching for mechanisms contributing to the increased mortality of acromegaly, we have previously described an unexpected sympathoinhibition in newly diagnosed patients (Seravalle et al., Clin Endocrinol 77:262, 2012) and interpreted this finding as an adaptive phenomenon. It has also been shown that centrally administered somatostatin (SS) inhibits peripheral sympathetic outflow in rodents (Rettig et al., Am J Physiol 257:R588, 1989). Ba...

ea0081ep668 | Pituitary and Neuroendocrinology | ECE2022

A multicenter retrospective study on a large cohort of patients with primary empty sella: hormonal and neuroradiological features over a long follow-up

Carosi Giulia , Brunetti Alessandro , Mangone Alessandra , Baldelli Roberto , Tresoldi Alberto , Sindaco Giulia Del , Lavezzi Elisabetta , Sala Elisa , Mungari Roberta , Fatti Letizia Maria , Galazzi Elena , Ferrante Emanuele , Indirli Rita , Biamonte Emilia , Arosio Maura , Cozzi Renato , Gerardo Antonio Lania Andrea , Mazziotti Gherardo , Mantovani Giovanna

Background: primary empty sella (ES) represents a frequent finding (up to 35% of the general population). According to the literature, the prevalence of hypopituitarism in ES ranges between 19-52%. Data on the natural history of ES over a long time, especially in incidental ES, are still lacking and the management can be challenging.Objective: our primary aim was to assess in a large cohort of patients with ES the prevalence and determinants of hypopitui...