Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep843 | Reproductive and Developmental Endocrinology | ECE2020

Hyperandrogenism in a postmenopausal woman secondary to an androgen secreting steroid cell tumor of the ovary

Bastos Filipa , Franco Sara , Ferreira Ana , Manita Isabel , Portugal Jorge

Introduction: Androgen secreting neoplasms of the ovary are rare and usually show autonomous secretion. Steroid cell tumors of the ovary represent less than 0.1% of all ovarian tumors and are a subgroup of sex cord-stromal tumors. In most cases, patients present with androgenic clinical features.Case report: A 58-year-old woman complained of rapid onset of androgenic alopecia, excessive hirsutism and clitoromegaly. Endocrine assessment showed high levels...

ea0099ep479 | Pituitary and Neuroendocrinology | ECE2024

New onset pituitary adenoma after cushing’s disease: recurrence or coincidence

Quitalo Ana , Leitao Francisca , Franco Sara , Lagarto Margarida , Vara Luiz Henrique , Raimundo Luisa

Introduction: Multiple pituitary adenomas (PA) have a prevalence of 0.2-2.6% of all resected PAs. However, most of them are simultaneously diagnosed and in the setting of acromegaly. In a 2019 surgical series with 22 cases of multiple PAs, only one case was asynchronous and all of them had a positive immunohistochemical staining.Case report: A 32-year-old woman (1996) was referred to na Endocrinology appointment with amenorrhea and weight gain for the la...

ea0081p535 | Adrenal and Cardiovascular Endocrinology | ECE2022

Minimally invasive treatment of conn’s adenoma: real world cases in tertiary oncology center

Costa Claudia , Franco Sara , Santos Ana Paula , Goncalves Belarmino , Gil-Santos Sara , Oliveira Joana , Souteiro Pedro , Jose Sousa Maria , Torres Isabel

Introduction: Primary aldosteronism (PA) is a rare but underestimated cause of hypertension. PA has been associated with increased risk of malignancy through mechanisms involving up-regulation of the renin angiotensin system (RAS) promoting an enzymatic cascade influencing carcinogenesis. Recently, Microwave Ablation (MWA) has been established as an effective and safe minimal invasive treatment for Conn’s Disease.Aim: The authors present four clinic...

ea0081p741 | Thyroid | ECE2022

Efficacy of radioactive iodine treatment in Graves Disease using a calculated 131I dose and predictive factors of success in a Portuguese cohort

Franco Sara , Teixeira Ferreira Rita , Cardoso Ferreira Ines , Quitalo Ana , Barbosa David , Manuel Costa Maria , Vara Luiz Henrique , Raimundo Luisa , Isabel Santos Ana

Aim: Dose corrected for thyroid gland size is one of the methods used to determine radioactive iodine (RAI) activity for patients with Graves disease (GD). This study was aimed to investigate the real-world success rate of this method and the predictors of success after first treatment.Methods: This is a retrospective study of 80 patients with GD treated between 2014 and 2020 in a tertiary referral hospital in Almada, Portugal. The successful group was d...

ea0090p388 | Endocrine-related Cancer | ECE2023

PRRT 177Lu-DOTA-TATE in pancreatic neuroendocrine tumors – When to initiate?

Franco Sara , Lucena Sampaio Ines , Ferreira Goncalo , Barbosa Daniel , Gil-Santos Sara , Vara Luiz Henrique , Paula Santos Ana , Torres Isabel , Duarte Hugo

Introduction: The best timing for PRRT (peptide receptor radionuclide therapy) in the case of pancreatic neuroendocrine tumors (panNETs) is still to define, as randomized prospective trials are lacking. Recent studies suggest that some systemic therapies can affect response to PRRT, favoring an earlier use of the latter.Objective: To determine the efficacy and toxicity of PRRT, comparing its results when used as a second line systemic therapy (a...

ea0070aep721 | Pituitary and Neuroendocrinology | ECE2020

Septo-optic dysplasia with late-onset diagnosis: An uncommon presentation of a rare disease

Duarte Vitória , Ivo Catarina , Veríssimo David , Franco Sara , Bastos Filipa , Marcelino Mafalda , Vara Luiz Henrique , Portugal Jorge

Background: Septo-optic dysplasia (SOD), also known as de-Morsier syndrome, is a rare congenital disorder characterized by any combination of optic nerve hypoplasia, pituitary dysfunction and midline abnormalities of the brain. Clinical diagnosis requires the presence of at least two of the features. This disorder is equally prevalent in males and females, with a reported incidence of 1/10,000 live births. There is wide variation in the severity of the clinical features found....

ea0070ep269 | Endocrine-related Cancer | ECE2020

Multiple endocrine neoplasia: A case series of 7 families

Duarte Vitória , Ivo Catarina , Veríssimo David , Marcelino Mafalda , Vara Luiz Henrique , Franco Sara , Bastos Filipa , Manita Isabel , Raimundo Luisa , Portugal Jorge

Introduction: Multiple endocrine neoplasia (MEN) is a rare genetic syndrome characterized by occurrence of tumors involving two or more endocrine glands. Four types are described: MEN1, MEN2, MEN3 and the recently identi&#-1279;ed MEN4. Due to the complexity of the syndromes, it is difficult to manage these patients. Our objective was to describe the clinical features of individuals from 7 families with a diagnosis of MEN1 or MEN2 and identify current challenges in clinical pr...

ea0099ep6 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Outcomes of gestational diabetes in native and non-native women – a three-year national study

Quitalo Ana , Leitao Francisca , Capitao Ricardo , Manuel Costa Maria , Franco Sara , Carlos Cordeiro Maria , Raimundo Luisa , de Estudo Diabetes e Gravidez Grupo

Introduction: In the last years, we have seen a high migration rate of people to Portugal. Not much is known about diet and lifestyle habits in some of these migrant women with gestational diabetes mellitus (GDM). On the other hand, communication can be a barrier and health care access may be more limited. For this reason, it is important to investigate whether there are differences in outcomes between these two populations, in order to question the need to change our clinical...

ea0073aep311 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Impact of the COVID pandemic and lockdown in the glycemic and weight control of patients with type 1 and type 2 diabetes – data from a Portuguese hospital

Franco Sara , Bastos Filipa C. , Ana Gonçalves Ferreira , Barbosa David , Ricardo Capitão , Costa Maria Manuel , Luiz Henrique Vara , Manita Isabel , Cordeiro Maria Carlos , Luísa Raimundo , Portugal Jorge

IntroductionDue to the COVID pandemic, Portugal was forced to start lockdown on March 18 th that lasted until June 1st. Lockdown caused a lot of changes in the daily activities of the Portuguese people, such as eating habits, exercise, time spent at home and stress management. After the lockdown people noticed difficult access to healthcare.ObjectiveOur aim was to evaluate if these changes had an i...

ea0073ep210 | Thyroid | ECE2021

Epithelioid hemangioendothelioma with thyroid involvement – case report

Franco Sara , Cardoso Catarina , Correia Rafaela , Sequeira Mafalda , Dinis Sousa Magno , Filipa C. Bastos , Sequeira Pedro , Raquel Miranda Ana , Abecassis Francisca , Ana Gonçalves Ferreira , Barbosa David , Vara Luiz Henrique , Jorge da Cunha Oliveira

Epithelioid hemangioendotheliomas (EHE) are rare vascular tumors that are typically low to intermediate grade, but they can also have an aggressive behaviour. Mortality rate is dependent on the tumor location. It is frequently a solitary lesion located in the superficial or deep soft tissues, but they can be found in liver, lungs (normally multifocal), pleura, bones, lymph nodes and rarely in the thyroid gland. We describe a case of metastatic EHE with involvement of the thyro...