Endocrine Abstracts

Background: Osteocalcin (OC) is a bone-specific protein produced primarily by osteoblasts during bone formation. The OC concentration is used to assess fracture risk and monitor treatment of osteoporosis and other disorders of bone metabolism. To adequately interpret the OC concentration, it is necessary to calculate reference ranges from a healthy reference population, adapted to a specific laboratory method.Methods: We established a healthy reference p...

Objective: IGF1 has almost 50% amino acid sequence homology with insulin and elicits nearly the same hypoglycaemic response. Studies showed that low and high IGF1 levels are related to impaired glucose tolerance and to a higher risk of type two diabetes. The aim of the present study was to evaluate the association between IGF1 level and insulin resistance in a Danish general population.Research Design and Methods: From the cross-sectional Health2006 stud...

Background: Persons with CAH may be at increased risk of developing adrenal myelolipomas, particularly if their CAH is poorly controlled. Adrenal masses can be detected by ultrasound with high sensitivity and specificity. Contrast-enhanced ultrasound (CEUS) may be a useful method in the diagnostic work-up of adrenal mass with excellent sensitivity for the diagnosis of malignancy. However, ultrasound is not included in the diagnostic algorithm of patients with CAH.<p class=...

We previously reported the impact of low-carbohydrate/high-fat (LC–HF) diets on different endocrine systems in rats. To unravel metabolic pathways involved, we now studied if pair-feeding isoenergetic amounts of three different diets – all composed of macronutrient from the same sources but at different relative abundance, – leads to specific changes of the plasma metabolic profile.Methods: Plasma was collected from male Wistar rats (n<...

Objective: In vitro and in vivo models revealed that the somatotropic system exerts central effects on the central nervous system. The objective of this study was to investigate for the first time whether varying endogenous IGF1 levels are associated with mental health outcomes, namely affective disorders, in humans.Design and methods: We included 6773 subjects from the DETECT study, a representative study on primary care patients in German...