Endocrine Abstracts

Introduction: Polycystic Ovary Syndrome (PCOS) is a very common endocrinopathy affecting 6 to 13% of women of reproductive age and one of the leading causes of female poor fertility. It was initially defined by the association of anovulation and clinical and/or biochemical hyperandrogenism (1990 National Institutes of Health-sponsored conference). Since Rotterdam ESHRE/ASRM Consensus Conference in 2003, polycystic ovaries morphology on ultrasound (ECHO condition) was added as ...

Diet, and especially metabolic dysregulation such as obesity can influence the ovarian activity. Adipose tissue plays an important role since it is known to be one of the most important endocrine organs producing hundreds of cytokines, such as adiponectin. Our team has observed that adiponectin modulated steroid secretion by the ovarian granulosa cells and its concentration in the follicular fluid was influenced by the metabolic status. Recently, a small adiponectin mimetic sy...

Adiponectin is one of the most abundant fat-derived hormones involved in a multitude of metabolism pathways. It acts as an anti-diabetic and anti-atherogenic adipokine. Adiponectin mediates its actions through mainly two receptors, AdipoR1 and AdipoR2. It has been postulated that although AdipoR1 and AdipoR2 consist of seven transmembrane helices, they are distinct from other G protein-coupled receptors. A role of adiponectin in ovarian physiology has been recently suggested. ...

Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants derived from the incomplete combustion of organic materials. In urban and industrial areas, level of pollution with these compounds is high, which leads to numerous negative health effects. Some literature data indicate the involvement of PAHs in the development of obesity, however, there is no data showing the distribution patterns of PAHs in human adipose tissue (AT) and their impact on the process o...