Searchable abstracts of presentations at key conferences in endocrinology

ea0014p552 | (1) | ECE2007

Determinants of the acromegalic cardiomyopathy: a prospective, controlled study in 205 patients

Colao Annamaria , Pivonello Rosario , Auriemma Renata S. , Galdiero Mariano , Spinelli Letizia , Galderisi Maurizio , Lombardi Gaetano

The most frequent cause of death in acromegaly is cardiomyopathy. To evaluate determinants of the acromegalic cardiomyopathy we performed an analytical, observational, open, prospective, controlled study in 205 patients with active acromegaly (108 women and 97 men) and 205 non-acromegalic subjects sex- and age-matched with the patients. We determined the prevalence of Left Ventricular (LV) hypertrophy (LVH), diastolic and systolic dysfunction, by echocardiography- measured LV ...

ea0020p26 | Adrenal | ECE2009

Cardiac structure and function in patients with adrenal incidentaloma: an echocardiographic study

De Leo Monica , Galderisi Maurizio , De Martino Maria Cristina , Cozzolino Alessia , Colao Annamaria , Pivonello Rosario , Lombardi Gaetano

Subclinical Cushing’s syndrome (SCS) is a mild autonomous cortisol hypersecretion without specific clinical syndrome of glucocorticoid excess. The aim of this study was to compare cardiac structure and function in patients with adrenal incidentaloma. Twenty patients and 20 sex- and age-matched healthy controls entered the study: among patients, 11 had SCS and the remaining nine had normal cortisol secretion All patients and controls were submitted to Doppler echocardiogra...

ea0020p196 | Endocrine tumours and neoplasia | ECE2009

Safety of long-term combined therapy with somatostatin analogues and cabergoline (CAB) on cardiac valve in acromegaly: an echocardiography study

Auriemma Renata Simona , Galderisi Maurizio , Galdiero Mariano , Grasso Ludovica Francesca Stella , De Martino Maria Cristina , De Leo Monica , Colao Annamaria , Pivonello Rosario

The aim of the present study was to evaluate cardiac valve insufficiency prevalence after 12-month combined treatment with somatostatin analogues (SA) and CAB in acromegalic patients partially responsive to high-dose and long-term SA monotherapy. Twenty-four patients entered the study. A standard echocardiography was performed in all patients at diagnosis, after high-dose and long-term SA therapy and 12 months after CAB addition to SA to evaluate ejection fraction (EF) and mit...

ea0016s30.5 | Clinical highlights | ECE2008

Increased prevalence of tricuspid regurgitation in patients with prolactinomas chronically treated with cabergoline: dose and treatment duration effect

Colao Annamaria , Galderisi Maurizio , Sarno Antonella Di , Pardo Moira , Gaccione Maria , D'Andrea Marianna , Pivonello Rosario , Guerra Ermelinda , Lerro Giuseppe , Lombardi Gaetano

Background: Cabergoline, a dopamine receptor-2 agonist, used to treat prolactinomas was associated with increased risk of cardiac valve disease.Objective: To evaluate prevalence of cardiac valve regurgitation in patients with prolactinomas treated with cabergoline.Design: Open, case–control, prospective.Patients: Fifty patients (44 women, 6 men) and 50 sex- and age-matched control subjects.<p class="...

ea0014p14 | (1) | ECE2007

Role of growth hormone/insulin like growth factor 1 system in the remodelling process of the right ventricle in top levels rowers

Vitale Giovanni , Galderisi Maurizio , Colao Annamaria , Innelli Pasquale , Guerra Germano , Guerra Ermelinda , Lloyd Dini Frank , Soscia Antonio , de Divitiis Oreste , Lombardi Gaetano

The intensive physical activity is often associated with cardiac changes, particularly involving the right ventricular (RV) chamber. However, the molecular mechanisms involved in the RV physiologic adaptation to long-term training are not completely understood. In the present study we investigated the role of the growth hormone/insulin like growth factor 1 (GH/IGF-1) axis in the RV remodeling of athletes.Nineteen male top levels rowers and 19 age-matched...