Searchable abstracts of presentations at key conferences in endocrinology

ea0029p357 | Clinical case reports - Pituitary/Adrenal | ICEECE2012

Germ cell tumor of the pituitary–hypothalamic region: case series and clinical experience in the Hospital Universitario Virgen del Rocío

Tous Romero M. , Venegas E. , Soto Moreno A. , Dios Fuentes E. , Garcia Garcia E. , Oliva Rodriguez R. , Garcia Hernandez N. , Leal Cerro A.

Background: Germ cell tumors (germinoma, teratoma, embryonal carcinoma, yolk sac tumor and choriocarcinoma) constitute 0.3–3.4% of all primary intracraneal tumors. Germinoma is the most common and of better prognosis.Aim: Describing the behaviour of germ cell tumors of the pituitary–hypothalamic region: location, clinical characteristics, diagnosis and follow-up.Material and methods: Review of medical records of patients ...

ea0029oc13.1 | Adrenal Basic | ICEECE2012

Targeting multiple signalling pathways showed high anti-tumour potential in two mouse phaeochromocytoma cell lines

Nolting S. , Garcia E. , Alusi G. , Korbonits M. , Grossman A.

Introduction: Since there is no completely effective therapy available for malignant phaeochromocytomas (PCCs) and paragangliomas, we have been investigating novel targeted therapies utilising one more benign (MPC) and one more malignant (MTT) PCC cell line. We have previously shown that the IGF1-receptor-inhibitor NVP-AEW541 led to compensatory ERK and mTORC1 up-regulation at suboptimal doses and that the dual PI3K/mTORC1-inhibitor NVP-BEZ235 also resulted in compensatory ERK...

ea0011p383 | Diabetes, metabolism and cardiovascular | ECE2006

Direct effect of cannabinoids and ghrelin on liver and adipose cell metabolism via the AMP-activated protein kinase (AMPK) enzyme

Dalino P , Aguilar D , Isidori AM , Hubina E , Garcia EA , Kola B , Grossman AB , Korbonits M

Cannabinoids and ghrelin exert hypothalamic orexigenic effects and independent peripheral effects have also been reported. We have recently reported that ghrelin and cannabinoids can stimulate hypothalamic and heart AMPK activity, and can inhibit liver and adipose tissue AMPK activity, in rats (Kola et al., JBC, 2005). These data are concordant with the known orexigenic, adipogenic and diabetogenic effects of these compounds as well as with their beneficial effects on t...

ea0010oc6 | Reproduction, neuroendocrinology and diabetes | SFE2005

Ghrelin and cannabinoids increase food intake via stimulation of hypothalamic amp-activated protein kinase (AMPK)

Adams V , Kola B , Garcia E , Hubina E , Dalino P , Khalaf S , Grossman|M##Korbonits A

Cannabinoids and ghrelin are potent appetite stimulators. The ghrelin receptor (GHS-R1a), endocannabinoids and the cannabinoid 1 (CB1) receptor are expressed in the hypothalamus. There is evidence that the novel CB1 antagonist, rimonabant, causes weight loss by both central and peripheral effects. The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status and regulates the energy metabolism within the single cell but also at whole body level. We have shown p...

ea0009p20 | Diabetes and metabolism | BES2005

Is ghrelin involved in BMI determination in patients with type 2 diabetes?

Garcia E , Gueorguiev M , Lecoeur C , Grossman A , Walley A , Froguel P , Korbonits M

Ghrelin is an orexigenic hormone, the endogenous ligand of the previously orphan growth-hormone-secretagogue receptor (GHS-R). Recently, it has been reported that pancreatic beta-cells are replaced by ghrelin-producing cells in a diabetic mice model implicating these genes as attractive candidates in the aetiology of type 2 diabetes (T2D) (PNAS;101:2924). The ghrelin gene is located at 3p25-26 and its cognate receptor at 3q26. We aimed to test for an association of these two g...

ea0029p1670 | Thyroid (non-cancer) | ICEECE2012

Iodine supply and prevalence of thyroid autoimmunity and autoimmune thyroiditis in children and adolescents between 1 and 16 years old in our city

Garcia-Garcia E. , Vazquez-Lopez M. , Garcia-Fuentes E. , Rodriguez-Sanchez F. , Munoz-Vico J. , Bonillo A. , Soriguer F.

Introduction: Thyroid autoimmunity is related to iodine supply. Iodine nutrition has improved in our country, but the prevalence of autoimmune thyroiditis in our children is unknown.Objectives: To determine the status of iodine nutrition in children and adolescents in our city. To calculate local prevalence of thyroid autoimmunity and autoimmune thyroiditis in pediatric ages.Design: Cross-sectional epidemiological study.<p clas...

ea0035p515 | Endocrine tumours and neoplasia | ECE2014

Our experience in the evaluation criteria used for the genetic study of patients suspected of being affected by multiple endocrine neoplasia type 1 and mutational spectrum

Oriola Josep , Sitges Antoni , Goday Albert , Martinez S , Villabona Carles , Gomez Jose Manuel , Loidi Lourdes , Salinas Isabel , Puig-Domingo Manel , Gonzalez-Romero E , Garcia-Arnes J A , Lecube Albert , Mesa Jordi , Simo Rafael , Rosell J , Sanchez-Garcia F , Recas Immaculada , Biarnes Josefina , Pizarro Eduarda , Halperin Irene

Introduction: The autosomal dominant multiple endocrine neoplasia type 1 (MEN1), characterized by parathyroid hyperplasia (PH), neuroendocrine digestive tumours (NET) and pituitary adenomas (PA), is due to mutations in the tumor suppressor gene MEN1 encoding a 610-amino acid protein, menin. Guidelines recommend MEN1 mutational analysis in index cases with two or more MEN1-associated tumours, in first-degree relatives of mutation carriers and when clinical dat...