Searchable abstracts of presentations at key conferences in endocrinology

ea0014p572 | (1) | ECE2007

Impairment of GH secretion by ghrelin stimulation test in primary hyperparathyroidism (PHP)

Cecconi Elisabetta , Giovannetti Clara , Manetti Luca , Raffaelli Valentina , Procopio Massimo , Ghigo Ezio , Gasperi Maurizio , Martino Enio

Pituitary GH secretion is regulated by the interplay of at least two hypothalamic hormones, GH-releasing hormone (GHRH) and somatostatin, through their interaction with specific cell surface receptors on the anterior pituitary somatotrophs. A third type of receptor, the growth hormone secretagogue receptor, called GHS receptor type 1a (GHSR1a), was identified in the pituitary and the hypothalamus. Ghrelin is an acylated peptide produced predominantly by stomach and a natural l...

ea0014p571 | (1) | ECE2007

Riluzole treatment does not affect growth hormone (GH) secretion in amyotrophic lateral sclerosis

Morselli Lisa Linda , Bongioanni Paolo , Genovesi Maura , Licitra Rosaria , Rossi Bruno , Murri Luigi , Gasperi Maurizio , Martino Enio

Amyotrophic lateral sclerosis (ALS), the most common motor neurone disorder in human adults, presents is characterized by selective and progressive degeneration of upper and lower motor neurones in central nervous system. GH secretion, evaluated by GHRH+arginine test, has been recently reported to be impaired in about 70% of untreated ALS patients. The currently available drug for ALS treatment is riluzole, a compound acting through inhibition of glutamate relase, post-synapti...

ea0032p830 | Pituitary–Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Mutations of SOX2 gene: a novel heterozygous mutation and impact on congenital hypopituitarism

Auriemma Renata S , Macchiaroli Annamaria , Kelberman Daniel , Faienza Maria F , Corona Rosalia , Mariano Iolanda , Giangiobbe Sara , Galdiero Mariano , Pivonello Rosario , Colao Annamaria , Gasperi Maurizio

Introduction: Anophthalmia/microphthalmia is a rare developmental craniofacial defect often associated to congenital hypopituitarism with GH deficiency and hypogonadism. SOX2 gene plays a key role in embryonic development regulation and heterozygous mutations of this gene, reported only in 14 patients to date, have been associated to anophthalmia/microphthalmia and congenital hypopituitarism in uo to 10% of cases. Therefore, the study of the SOX2 gene can be clinically useful ...

ea0032p866 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effects of short (12 months) and long (60 months) term treatment with cabergoline on metabolic syndrome and visceral adiposity index in patients with hyperprolactinemia

Auriemma Renata S , Granieri Luciana , Perone Ylenia , Galdiero Mariano , Grasso Ludovica , Simeoli Chiara , Pivonello Claudia , Gasperi Maurizio , Giordano Carla , Colao Annamaria , Pivonello Rosario

Introduction: Hyperprolactinemia is reportedly associated with an impaired metabolic profile, particularly in patients with concomitant hypogonadism. The current study aimed at investigating the effects of short (12 months) and long (60 months) treatment with cabergoline (CAB) on metabolic complications, metabolic syndrome (MS) prevalence and visceral adiposity index (VAI) in hyperprolactinemic patients.Patients and methods: Seventy-one patients (51 F, 2...