Endocrine Abstracts

Aims: Spain has been one of the worst affected countries by the COVID-19 pandemic. A very strict lockdown at home was imposed with a tough restriction of mobility. We aimed to evaluate the impact of this exceptional scenario on glucose profile of patients with type 1 diabetes (T1D) prone to hypoglycemia using sensor-augmented pump (SAP).Methods: Patients with T1D prone to hypoglycemia using SAP (640G Medtronic Minimed) for at least 6 months under the fun...

Aims: Spain has been one of the worst affected countries by the COVID-19 pandemic. A very strict lockdown at home was imposed with a tough restriction of mobility. We aimed to evaluate the impact of this exceptional scenario on glucose profile of patients with type 1 diabetes (T1D) prone to hypoglycemia using standalone continuous glucose monitoring.Methods: Patients with T1D prone to hypoglycemia using multiple daily injections and either a Dexcom G5 or...

Introduction: PWS is the most common cause of genetic obesity. These patients have an abnormal body composition with increased amounts of fat mass (FM), reduced lean body mass (LBM) and diminished bone mineral density (BMD), all similar to patients with growth hormone deficiency (GHD).The abnormal body composition has been described due to impairment of the activity of GH-IGF system and to hypogonadism. Studies ongrowth hormone (GH) treatment in PWS adults from other European ...

Background: Prader-Willi syndrome (PWS) is a genetic neurodevelopmental disorder characterized by marked hyperphagia and morbid obesity, together with hormone deficiencies, abnormal behaviour in relation to food (obsessive thinking, food foraging, stealing, etc.). Veins in patients with PWS are difficult to find due to obesity and probably to generalised hypotonia including venous tone. Since treating a patient with PWS often requires the acquisition of blood samples, an exper...

BackgroundPrader Willi syndrome (PWS) is a genetic disorder with a broad clinical expression. Severe hypotonia with feeding difficulties during early infancy and delayed motor development are very characteristic. At older ages, common motor features in the PWS phenotype include decreased muscle strength, deficiencies in motor coordination and sequencing, gait disturbances and dyspraxic manifestations, with no clear pathophysiological mechanism yet identi...

BackgroundCentral kisspeptin action is well known in reproductive regulation; however, its peripheral action is not well understood. Most studies reveal that kisspeptin signaling influences energy and metabolic status.ObjectiveTo compare serum kisspeptin levels 1) between adult patients with PWS, obese subjects matched for age, sex and BMI and healthy subjects; 2) in adult patients with PWS before and after t...