Endocrine Abstracts

Objective: To study HbA1c as a tool for diagnosing diabetes and to study HbA1c as a cardiovascular risk marker in patients with polycystic ovary syndrome (PCOS).Methods: A retrospective observational study at an academic tertiary-care medical center. In total, 208 premenopausal women with PCOS participated. Patients underwent clinical evaluation (Ferriman–Gallwey score, body mass index, waist, blood pressure), hormone analyses (testosterone, sex hor...

Objective: PCOS may be associated with an increased risk of endometrial hyperplasia (EH) and endometrial cancer (EC), but substantial evidence remains to be established. We investigated the prevalence of EH and EC in a well-characterized group of women with PCOS and/or clinical/biochemical hyperandrogenism.Design: Retrospective, trans-sectional study.Setting: Out-patient clinic at the Departments of Endocrinology and Gynecology, Od...

Introduction: PCOS is characterized by insulin resistance and an increased risk of type 2 diabetes.Objective: To study the association between birth weight and risk of polycystic ovary syndrome (PCOS) in adult life in Danish women born 1973–1991.Methods: Female offspring born in Denmark during 1973–1991 of Danish mothers (n=523, 757) were included and followed for a total of 4, 739, 547 person-years at risk. Inform...

Objective: The cardiovascular effects of testosterone treatment are debated. Osteoprotegerin (OPG) is an independent marker of cardiovascular risk. We investigated the effect of testosterone therapy on OPG levels in ageing men with low normal bioavailable testosterone levels.Design: A randomized, double-blinded, placebo-controlled study of six months testosterone therapy (gel) in 38 men aged 60–78 years with bioavailable testosterone <7.3 nmol/l...

Objective: Smoking may be associated with changes in metabolic risk factors and sex hormones in PCOS.Design: Retrospective trans-sectional study.Patients: Six hundred and fifty caucasian premenopausal women with the diagnoses hirsutism or PCOS were divided according to smoking status: Non-smokers (NS-PCOS=390) and smokers (S-PCOS=260). 119 healthy women were studied as controls (NS-Control=105, S-Control=14)....