Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp150 | Pituitary - Clinical | ECE2016

Treatment of acromegaly increases BMD but reduces Trabecular Bone Score – a longitudinal study

Godang Kristin , Cristina Olarescu Nicoleta , Bollerslev Jens , Heck Ansgar

Background: Bone turnover is increased in active acromegaly. Despite normalization of bone turnover after treatment, the risk for vertebral fractures remains increased. Gonadal status, but not bone mineral density (BMD) is correlated to vertebral fracture incidence. Trabecular and cortical bone are differentially affected by GH and IGF-1. The trabecular bone score (TBS) is related to bone microarchitecture and provides further information not captured by BMD measurement.<p...

ea0037ep766 | Pituitary: clinical | ECE2015

The metabolic relevance of angiopoietin-like protein 4 in different states of GH/IGF1 excess or deficiency

Olarescu Nicoleta Cristina , Jorgensen Anders P , Heck Ansgar , Normann Kjersti R , Godang Kristin , Bollerslev Jens

Context: Angiopoietin-like protein 4 (Angptl4) is a protein involved in lipolysis, that is regulated by non-esterified free fatty acids (FFA). GH promotes lipolysis and increases circulating FFA. Hypothesis: GH increases circulating Angptl4 levels by modulating its expression and secretion from fat and muscle. Angptl4 might be of metabolic relevance for the insulin resistance associated with GH/IGF1 excess or deficiency.Objective: To evaluate Angptl4 in ...

ea0035oc8.1 | Pituitary clinical | ECE2014

Metabolic improvement after treatment of acromeglay is determined by the increase of gynoid fat mass and the decrease of serum vaspin and IGF1

Olarescu Nicoleta C. , Heck Ansgar , Godang Kristin , Ueland Thor , Bollerslev Jens

Context: Adipose tissue distribution is closely related to metabolic disease risk. GH reduces visceral and total body adipose tissue mass, while inducing whole body insulin resistance.Objective: To assess the role of visceral adipose tissue and derived adipokines for the systemic insulin resistance and lipid metabolism, before and after treatment in acromegaly.Patients: Sixty-six adult patients with active acromegaly diagnosed betw...

ea0063gp111 | Calcium and Bone 2 | ECE2019

Hip structure analyses in acromegaly: Decrease of cortical bone thickness after treatment

Godang Kristin , Lekva Tove , Normann Kjersti R , Olarescu Nicoleta Cristina , Oystese Kristin AB , Kolnes Anders , Ueland Thor , Bollerslev Jens , Heck Ansgar

Background: Long standing growth hormone (GH) excess causes the skeletal clinical signs of acromegaly with typical changes in bone geometry including increased cortical bone thickness (CBT). However, a high prevalence and incidence of vertebral fractures has been reported. The aim of this study was to assess the course of cortical bone dimensions in the hip by comparing patients with acromegaly and clinically non-functioning pituitary adenomas (NFPA) at baseline and one year a...

ea0037ep1350 | Endocrine nursing | ECE2015

Continuous subcutaneous hydocortisone infusion replacement treatement in adrenal insufficiency – how to start the hydrocortisone infusion

Simunkova Katerina , Jovanovic Nevena , Rostrup Espen , Methlie Paal , Oksnes Marianne , Nilsen Roy Miodini , Henno Hanne , Tilseth Mira , Godang Kristin , Kovac Ana , Lovas Kristian , Husebye Eystein Sverre

Many patients with primary adrenal insufficiency (AddisonÂ’s disease) take extra doses of glucocorticoids before or during stressful events, but benefit has not been demonstrated. We aimed to test the effect of an extra dose of glucocorticoids on cardiorespiratory, hormonal and metabolic parameters in response to physical activity in a randomised placebo-controlled, 2-weeks cross-over, clinical trial (clinicaltrials.gov NTC01847690). Ten women with AddisonÂ’s disease a...