Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1464 | Pituitary Clinical | ICEECE2012

Parasellar masses: experience in 47 patients

Saraiva J , Gomes L , Paiva I , Vieira A , Alves M , Gouveia S , Moreno C , Carvalheiro M

Introduction: The differential diagnosis of nonpituitary sellar masses is broad. Clinical presentation may be similar to that of pituitary adenomas. Sometimes certain findings are particular to some lesions and may help in their differentiation. Correct preoperative diagnosis is important to better guide therapeutic management. The aim of this work was to analyze patients with parasellar lesions (craniopharyngiomas excluded), attended in the Department of Endocrinology of our ...

ea0026p179 | Neuroendocrinology | ECE2011

X-linked adrenoleukodystrophy: an intersection between Endocrinology and Neurology

Gouveia S , Gomes L , Ribeiro C , Vieira A , Alves M , Saraiva J , Carvalheiro M

Introduction: X-linked adrenoleukodystrophy (X-ALD) is an important cause of primary adrenocortical insufficiency (PAI) in men. It’s characterized by impairment in peroxisomal degradation of very-long-chain-fatty-acids (VLCFA), leading to its accumulation on central nervous system, adrenal cortex and testes.Adrenomyeloneuropathy, the most common phenotype of X-ALD, coexists with PAI in up to 70% cases.Case report: A 28-year-ol...

ea0026p239 | Pituitary | ECE2011

Pituitary apoplexy as initial manifestation of pituitary tumors: two case reports

Saraiva J , Gomes L , Paiva I , Santos J , Vieira A , Alves M , Gouveia S , Carvalheiro M

Introduction: Pituitary aplopexy is rare (0.6 to 12.3%). Sudden expansion of pituitary tumor, from hemorrhage or infarction, may lead to permanent vision loss, paresis or death. We describe two cases of apoplexy as the initial manifestation of pituitary tumor.Case 1: Male, 30 years, healthy, observed in the emergency room (ER) complaining of headache, visual deficit and left ptosis for 3 days. He had left ptosis and bilateral paresis of the IV pair. Magn...

ea0011p81 | Clinical case reports | ECE2006

Invasive prolactinoma with multiple recurrences: pituitary atypical adenoma or pituitary carcinoma? Report of a case

Gomes L , Paiva I , Ribeiro C , Gomes F , Rito M , Rebelo O , Carvalheiro M

Background: Invasive pituitary tumors may behaviour like some pituitary carcinomas. Although invasiveness is not indicative of malignancy, it probably puts the patient at higher risk of developing a pituitary carcinoma. These are very rare and the diagnosis requires evidence of metastatic disease, either cerebrospinal or extracranial. Although de novo development cannot be excluded they usually present as typical pituitary adenomas, which reveal their malignant characte...

ea0011p130 | Clinical case reports | ECE2006

Adult-onset nesidioblastosis- a rare clinical case

Martins T , Gomes L , Guimarães J , Melo M , Carvalheiro M

Introduction: Nesidioblastosis is a rare but well recognized disorder of persistent hyperinsulinemic hypoglycemia in infancy, but adult-onset nesidioblastosis associated with hyperinsulinemic hypoglycemia, termed noninsulinoma pancreatogenous hypoglycemia syndrome (NIPHS) has also been reported. These patients experience predominantly postprandial hypoglycaemia instead of fasting hypoglycaemia that characterizes insulinoma. Histological findings are islet hypertrophy islet-cel...

ea0029p407 | Clinical case reports - Thyroid/Others | ICEECE2012

Considering familial benign hypocalciuric hypercalcemia on differential diagnosis of primary hyperparathyroidism

Gouveia S. , Paiva S. , Gomes L. , Ribeiro C. , Vieira A. , Alves M. , Saraiva J. , Moreno C. , Carvalheiro M.

Introduction: Primary hyperparathyroidism is the most common cause for hypercalcemia. Familial benign hypocalciuric hypercalcemia (FBHH) is an unusual autosomal dominant disease. The mutation in the calcium sensing receptor (CaSR) determines a shift to the right in the calcemia set-point that inhibits PTH secretion. Generally asymptomatic, these patients present with mild hypercalcemia and hypophosphatemia, normal or slightly increased PTH levels and hypocalciuria. Daily calci...

ea0029p878 | Endocrine tumours and neoplasia | ICEECE2012

Metastatic malignant insulinoma

Moreno C. , Rodrigues A. , Gomes L. , Ruas L. , Barros L. , Paiva S. , Vieira A. , Alves M. , Gouveia S. , Saraiva J. , Carvalheiro M.

Introduction: Insulinomas are the most common form of functioning pancreatic neuroendocrine tumors (NET) with an estimated incidence of 1–3/million per year. Less than 10% are malignant and rarely with distant metastases, carrying a poor prognosis.Case report: We report a case of a 73-years-old woman attended at our ER for recurrent syncope, with irrelevant medical history. Several radiology exams were preformed, revealing numerous liver metastases ...

ea0029p719 | Diabetes | ICEECE2012

Continuous subcutaneous insulin infusion systems: experience in 92 patients with type 1 diabetes

Saraiva J. , Carrilho F. , Barros L. , Batista C. , Melo M. , Gomes L. , Vieira A. , Alves M. , Gouveia S. , Moreno C. , Carvalheiro M.

Background: Continuous subcutaneous insulin infusion (CSII) using an external pump is an alternative intensive diabetes therapy recognized to improve metabolic control and glycemic instability in selected type 1 diabetic (T1DM) subjects. The aim of this study was to examine the clinical effectiveness and safety of CSII systems over a 5-year follow-up period in T1DM patients.Materials and methods: We performed a retrospective observational study of T1DM p...