Endocrine Abstracts

Introduction: Liraglutide treatment reduces cardiovascular complications in patients with diabetes mellitus (DM), which may imply a favorable impact on the endothelial function. The aim of the present study was to investigate in vitro the effect of liraglutide on endothelial redox balance and the parallel expression of CRH, UCN1, 2 and 3 neuropeptides, under normoglycemic and hyperglycemic conditions.Methods: Macroendothelial cell line EAhy926 w...

Introduction: Diabetes is characterised by increased oxidative stress and an insufficient antioxidant response, which are crucial for the initiation and progression of atherosclerosis. GLP-1 agonists, used for the treatment of diabetes, are considered as cardioprotective agents but under that concept, there are limited data on their ability to influence the endothelial antioxidant response.Methods: In order to answer this question we studied the influenc...

Corticotropin-releasing hormone (CRH) and Urocortin 2 (Urn2) are secreted locally in peripheral tissues and play a direct immunomodulatory role as endocrine or paracrine mediators of inflammation. Studies on CRH as well as Ucn2 and vascular endothelial cells suggest that CRH may play a pivotal role in the regulation of vascular endothelial function under normal and pathological conditions. The present study was undertaken to determine whether CRH and Urn2 affect the endothelia...

Introduction: Polycystic ovary syndrome (PCOS) is usually accompanied by abdominal obesity and insulin resistance which are related with low-grade chronic inflammation, as evidenced by elevation of multiple markers of inflammation, among which is oxidative stress. However, as far as oxidative stress presence, the existing data are limited. The purpose of this study was the investigation of several oxidative stress markers in women with PCOS without insulin resistance.<p cl...