Endocrine Abstracts

Murine protein serine-threonine kinase 38 (MPK38), also known as maternal embryonic leucine zipper kinase (Melk), is a member of the AMP-activated protein kinase (AMPK)-related kinase family and regulates multiple cellular processes, including cell cycle, stem cell self-renewal, apoptosis, carcinogenesis, and metabolism, and is activated in response to apoptosis signal-regulating kinase 1 (ASK1)/TGF-β/p53 signals. A serine/threonine protein phosphatase PP5 has been sugges...

Purpose: Denosumab is a monoclonal antibody that prevents osteoclast development. The effect of denosumab in solid organ transplant recipients has been elucidated, but the effect of denosumab in hematopoietic stem cell transplantation recipients has not been studied yet. Thus, the aim of this study was to determine the effectiveness and safety of denosumab in hematopoietic stem cell transplantation recipients.Methods: We retrospectively evaluated 27 pati...

Introduction: Diabetes as a risk factor of cancer should be explored further. The value of PSA is limited because we cannot exclude prostate cancer in lower PSA levels. We analyzed diabetes and the risk of prostate cancer in lower PSA in a large cohort study.Method: A total of 179 456 health examinees (men, aged 30–89 years) from 1994 to 2010 were participated. Participants with any cancer or potential prostate diseases were excluded from analysis. ...

Thyrotoxic hypokalaemic periodic paralysis (THPP) is an uncommon potentially life-threatening endocrine emergency characterized by sudden onset of muscle weakness with hypokalaemia that resolves with treatment of hyperthyroidism. Reported predominantly among individuals of Asian descent, THPP is rare in western populations. We present 2 cases of THPP diagnosed within 6 months in a district general hospital.First patient: a 37 year white male presented wi...

Background: The purpose of this study was to measure the ability of Microvascular ultrasonography (MVUS), which is a third-generation Doppler technique developed to increase sensitivity, to distinguish Graves’ disease (GD) from destructive thyroiditis (DT).Methods: This prospective study included a total of 167 patients from October 2020 to January 2023. Of them, 85 were patient with GD. All ultrasonography examinations were performed using microvas...

Annona squamosa has been shown to have anti-diabetic properties, although the underlying mechanisms are not fully known. In the present study, ethanol extract A. squamosa (EEAS) leaf were investigated in vitro and in vivo, to elucidate the mechanism underlying anti-diabetic actions. EEAS significantly (P<0.05–0•001) increased insulin release 2.2-5.5-folds at 5.6 mM/16.7 mM glucose at concentrations between 8-5000µg/ml from BRIN-BD1...

Traditional herbal medicine has been used for centuries to treat various chronic diseases – There have been some anecdotal evidence to suggest that the use of some of these herbal medicine may be both safe & efficacious in patients and laboratory animals with diabetes. Many patients with diabetes worldwide use some of these medicines without informing their caring physicians. PHS-E2 (Glucoherb) is a Chinese traditional herbal medicine, which is extracted from two medi...

Low-dose persistent organic pollutants (POPs), especially organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), have emerged as a new risk factor for type 2 diabetes. We evaluated whether chronic exposure to low-dose POPs affects insulin secretory function of β-cells in humans and in vitro cells. Serum concentrations of OCPs and PCBs were measured in 200 adults without diabetes. Mathematical model-based insulin secretion indices were estimated by...

Objective: Diabetes mellitus (DM) is known to be associated with a lower trabecular bone score (TBS) and an increased risk of fracture. However, little is known regarding whether it is associated with poor bone results in pre-diabetic individuals. Despite the fact that both IFG and IGT are characterized by insulin resistance and β-cell dysfunction, the metabolic abnormalities are quite distinct between the two disorders. Impaired fasting glucose (IFG) was marked by dysfun...

Aim: Insulin-releasing effects and potential anti-diabetic actions of peptides isolated from the skin secretion of the African clawed frog, Xenopus amieti has been reported. However, peptides such as magainin-AM1 has not been previously studied for its ability to stimulate insulin secretion or promote glucose uptake. This study investigated insulin releasing effects as well as possible underlying mechanisms.Methods: Acute and chronic actions of ...