Endocrine Abstracts

Aim: Beneficial effects of Jatropha tanjorensis (J. tanjorensis) extracts in African traditional medicinal practices for the management of type 2 diabetes have been reported. However, mechanisms through which these extracts exert their anti-diabetic actions have not been widely studied.Methods and materialsEffects of various aqueous extracts of root, leaf, and bark J. tanjorensis (0-1000 μg/ml) on insulin-release, cytotoxicity and cell viability were investigated using BR...

1=School of Sciences, Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton, UK 2= Department of Biochemistry, Obafemi Awolowo University, Ile-Ife, Nigeria3= IRiD Biosciences, Wilding Road, Ball Green, Stoke-on-Trent, ST6 8BQAim: Vernonia amygdalina extract is used traditionally for type 2 diabetes treatment in developing countries. Studies have reported antidiabetic properties of aqueous...

Aim: The use of commonly consumed vegetables, such as Pterocarpus mildbraedii, in the treatment of metabolic conditions is consistent with the food-as-medicine strategy. To characterise its pharmacological actions, this study assessed insulin-releasing and glucose lowering effects of effects of P. mildbraedii in models of type 2 diabetes.Methods: Clonal pancreatic cells, BRIN-BD11, were treated P. mildbraedii extracts...