Searchable abstracts of presentations at key conferences in endocrinology

ea0022p1 | Adrenal | ECE2010

Differentiation between benign and malignant adrenal mass using contrast-enhanced ultrasound

Friedrich-Rust Mireen , Glasemann Timo , Holzer Katharina , Kiener Susanne , Herrmann Eva , Polta Andreas , Zeuzem Stefan , Bojunga Joerg

Background: Adrenal masses can be detected by ultrasound with high sensitivity and specificity. However, a differentiation between benign and malignant adrenal masses is not possible with conventional ultrasound. Contrast-enhanced ultrasound (CEUS) is a established method for the characterization of focal liver lesions. A first pilot study (n=35) analyzing the dynamics of contrast-enhancement during CEUS reported a high sensitivity for differentiation of benign and mali...

ea0020p59 | Thyroid | ECE2009

Real-time elastography and contrast-enhanced ultrasound for the assessment of thyroid nodules

Friedrich-Rust Mireen , Sperber Andrea , Holzer Katharina , Gruenwald Frank , Badenhoop Klaus , Bechstein Wolf , Zeuzem Stefan , Bojunga Joerg

Background and aims: The aim of the present study was to evaluate real-time elastography (RTE) and contrast-enhanced ultrasound with Sonovue (CEUS) for the differentiation of benign and malignant thyroid nodules using cytologic/histologic analysis as reference method. While first studies have reported excellent results of RTE for the differentiation of thyroid nodules, data on CEUS of the thyroid are rare.Methods: RTE was classified as: score 1=soft, 2=p...

ea0032p1093 | Thyroid cancer | ECE2013

Interobserver agreement of thyroid imaging reporting and data system and realtime elastography for the assessment of thyroid nodules

Friedrich-Rust Mireen , Meyer Gesine , Dauth Nina , Berner Christian , Herrmann Eva , Schroeter Hartmut , Holzer Katharina , Voelkl Lisa , Zeuzem Stefan , Bojunga Joerg

Introduction: Work-up of thyroid nodules remains challenging. Thyroid imaging reporting and data system (TIRADS) has been developed to improve patient management and cost-effectiveness by avoiding unnecessary fine needle aspiration biopsy (FNAB) in patients with thyroid nodules. However, since its publication in JCEM (2009) its clinical use is still very limited and its practicability in clinical practice is questioned. Realtime-elastography (RTE) enables the determination of ...

ea0016p307 | Endocrine tumours | ECE2008

VDR gene polymorphisms in patients with differentiated thyroid cancer

Penna-Martinez Marissa , Stern Julienne , Kahles Heinrich , Reusch Jurgen , Hinsch Nora , Hansmann Martin-Leo , Selkinski Ivan , Grunwald Frank , Wahl Robert , Holzer Katharina , Ramos-Lopez Elizabeth , Badenhoop Klaus

Background/aim: Vitamin D receptor (VDR) expression has been shown to be upregulated in several tumors and is thought to represent an important endogenous response to tumor progression. Therefore, in order to evaluate the role of VDR-gene and of the 25(OH)-Vitamin D3 in thyroid cancer we analysed four polymorphisms in patients with thyroid cancer and healthy controls.Patients and methods: Patients (n=136; 84 females and 52 males) with d...

ea0022p381 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

CYP24A1 haplotypes are associated with differentiated thyroid carcinoma

Penna-Martinez Marissa , Ramos-Lopez Elizabeth , Stern Julienne , Kahles Heinrich , Hinsch Nora , Hansmann Martin-Leo , Selkinski Ivan , Grunwald Frank , Vorlander Christian , Wahl Robert A , Bechstein Wolf O , Zeuzem Stefan , Holzer Katharina , Badenhoop Klaus

Background: Previously, we reported an association of vitamin D receptor (VDR) polymorphisms and differentiated thyroid cancer (DTC) risk. The aim of the present study was to investigate other vitamin D pathway genes such as CYP27B1, CYP2R1 and CYP24A1 which code for enzymes that, respectively, synthesize and degrade 1,25(OH)2D3 in patients with DTC and healthy controls (HC). Also its influence on 25(OH)D3 and 1,25(OH)2D3 ...