Searchable abstracts of presentations at key conferences in endocrinology

ea0032p9 | Adrenal cortex | ECE2013

Insulin sensitivity in patients with Addison's disease: a randomised cross-over trial comparing conventional glucocorticoid replacement therapy with continuous subcutaneous hydrocortisone infusion therapy.

Bjornsdottir Sigridur , Nystrom Thomas , Isaksson Magnus , Oksnes Marianne , Husebye Eystein , Lovas Kristian , Kampe Olle , Hulting Anna Lena , Bensing Sophie

Background: Conventional glucocorticoid replacement therapies result in unphysiological variation in plasma cortisol levels; concern has been raised regarding long-term metabolic consequences. Glucocorticoid replacement is technically feasible by continuous subcutaneous hydrocortisone infusion (CSHI), which can mimic the normal diurnal cortisol rhythm. The aim of this study was to compare insulin sensitivity in patients with Addison’s disease (AD) on CSHI vs three daily d...

ea0022p12 | Adrenal | ECE2010

Autoimmune disorders in Addison's disease and in isolated secondary adrenal insufficiency

Kasperlik-Zaluska Anna A , Czarnocka Barbara , Jeske Wojciech , Bednarek-Papierska Lucyna , Hulting Anna-Lena , Bensing Sophie , Crock-Ludecke Patricia , Kampe Olle

Autoimmunity is the most frequent cause of Addison’s disease (AD). Isolated secondary adrenal insufficiency (ISAI) in patients not treated with corticosteroids seems to be an autoimmune disease too. In the registry of the Department of Endocrinology in Warsaw we have 328 patients with AD and 305 patients with ISAI. Autoimmune AD was diagnosed in 262 of 328 patients (77%) and in 217 of them (83%) some associated autoimmune disorders were found, while in the group with ISAI...

ea0022p619 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Lymphocytic hypophysitis: clinical characteristics and endocrine features of 64 GH deficient patients in KIMS: Pfizer International Metabolic Database

Bensing Sophie , Jonsson Peter , Hulting Anna-Lena , Cook David , Gordon Murray , Faust Michael , Koltowska-Haggstrom Maria , Casanueva Felipe

Objective: To characterize patients with GH deficiency associated with lymphocytic hypophysitis (LyH).Method: Patients with a diagnosis of LyH were identified in the KIMS database. The responsible clinicians were asked to confirm the diagnosis and to provide more detailed information on the patient by filling in a questionnaire.Results: One hundred and fifty patients with a diagnosis of LyH were identified in the database and 100 c...

ea0020p13 | Adrenal | ECE2009

Autoimmune adrenal insufficiency: Addison's disease versus idiopathic isolated secondary adrenal insufficiency

Kasperlik-Zaluska Anna , Czarnocka Barbara , Jeske Wojciech , Papierska Lucyna , Hulting Anna-Lena , Bensing Sophie , Crock Patricia , Kampe Olle

Studies on autoimmune Addison’s disease (AD) have a long tradition, while knowledge on idiopathic isolated secondary adrenal insufficiency (SAI), which also seems to be caused by autoimmunity, is not so popular. Our presentation aimed at comparing two groups of patients: 1) 238 patients with AD (183 women, F/M=4.3), aged 8–61 years at time of diagnosis and 2) 301 patients with SAI (269 women, F/M=8.4), aged 17–87 years at time of diagnosis. Maximum time of durat...

ea0035p33 | Adrenal cortex | ECE2014

Circadian cortisol and GH profiles in patients with Addison's disease: a comparison of continuous subcutaneous hydrocortisone infusion with conventional glucocorticoid replacement therapy

Oksnes Marianne , Bjornsdottir Sigridur , Isaksson Magnus , Methlie Paal , Nilsen Roy , Kampe Olle , Hulting Anna-Lena , Husebye Eystein , Lovas Kristian , Nystrom Thomas , Bensing Sophie

Background: Conventional glucocorticoid replacement therapy in patients with Addison’s disease (AD) is unphysiological with possible adverse effects on mortality, morbidity and quality of life. Physiological amounts of glucocorticoids are required for normal GH production and release and a chronically raised cortisol level, suppresses the secretion of GH with possible metabolic and cardiovascular consequences. The diurnal cortisol profile can likely be restored by continu...

ea0032s21.2 | Multi-centre pituitary studies | ECE2013

Lessons from the Liège Acromegaly Survey (LAS)

Petrossians Patrick , Zacharieva Sabina , Chanson Philippe , Neggers Sebastian , Brue Thierry , Colao Annamaria , Hulting Anna-Lena , Delemer Brigitte , Hana Vaclav , Stalla Gunter , Minuto Francesco , Jaffrain-Rea Marie-Lise , Carvalho Davide , Montanana Carmen Fajardo , Beckers Albert

The Liège Acromegaly Survey is a cross-sectional study on acromegalic patients, developed as an in-house tool in Liège, then extended to other Europeans participating centers. The database differentiates itself from national and multinational registries by adopting a goal oriented approach and it was conceived following a list of open questions on acromegaly. After an initial test run in Liège, the database installation started on mid-March 2010. Thirteen other ...

ea0028oc3.6 | Obesity, thyroid and Addison's disease | SFEBES2012

GATA3 polymorphisms are associated with autoimmune Addison’s disease

Mitchell Anna , MacArthur Katie , Gan Earn , Baggott Lucy , Wolff Anette , Skinningsrud Beate , Short Andrea , Kampe Olle , Bensing Sophie , Betterle Corrado , Kasperlik-Zaluska Anna , Czarnocka Barbara , Fichna Marta , Hulting Anna-Lena , Badenhoop Klaus , Falorni Alberto , Ollier William , Undlien Dag , Husebye Eystein , Pearce Simon

Autoimmune Addison’s disease (AAD) is a rare, highly heritable endocrinopathy with an estimated λsibling (ratio of risk to a sibling vs the unrelated background population) of 160–210. The majority of the genetic risk to AAD has yet to be accounted for. We have used a tag-SNP approach to seek association between single nucleotide polymorphisms (SNPs) in the GATA3 gene and autoimmune Addison’s disease (AAD). 2001 AAD cases and 1898 controls were included in ...