Searchable abstracts of presentations at key conferences in endocrinology

ea0059s3.1 | Horizons in adrenal medicine | SFEBES2018

Novel strategies in glucocorticoid replacement

Husebye Eystein

Primary adrenal insufficiency (AI) is often a consequence of autoimmune destruction of the adrenal cortex, but a number of other causes have been reported, including genetic diseases, haemorrhage, infections, infiltration by tumour or metastasis, and medication. AI is rare with reported prevalence at 10–20 per 100 000 inhabitants. Before replacement therapy with corticosteroids became available, AD was invariably fatal. Accessibility to hydrocortisone and fludrocortisone ...

ea0022s1.5 | European networks | ECE2010


Husebye Eystein

Autoimmune Addison’s disease (AAD) is an endocrine disease resulting from the immune system’s destruction of hormone producing cells in the adrenal cortex. Diagnosis is frequently first established after a life-threatening adrenal crisis, often resulting in untimely fatalities. The disease is rare, more common in women than in men, and also affects children. AAD very frequently occurs with other autoimmune diseases, such as type 1 diabetes mellitus, autoimmune thyroi...

ea0021cm1.4 | Long-term consequences of endocrine diseases | SFEBES2009

Addisons disease

Husebye Eystein

Primary adrenal insufficiency is often a consequence of autoimmune destruction of the adrenal cortex. Mortality is increased primarily due to acute adrenal crises, especially among patients diagnosed at young age. In the long-term more than 50% of the patients will develop other autoimmune diseases or manifestations, particularly autoimmune thyroid disease. Despite seemingly adequate treatment, accumulating evidence document reduced subjective health status, particularly gener...

ea0081oc12.2 | Oral Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Genetic cause of POI are common, the case for next generation sequencing?

Vogt Elinor , Bratland Eirik , Husebye Eystein Sverre , Bjornsdottir Sigridur , Berland Siren , Oksnes Marianne

Context: Premature ovarian insufficiency (POI) affects approximately 1-3% of women. Clinical presentations are heterogeneous and the underlying etiologies remain unknown in the majority of cases.Objective/aim: To characterize presentations of POI and to evaluate the distribution of underlying etiologies in women with newly diagnosed POI of unknown cause.Design: Prospective study of 100 women with newly diagnosed POI. Autoimmunity w...

ea0081p14 | Adrenal and Cardiovascular Endocrinology | ECE2022

Profound changes of inflammatory and cardiovascular biomarkers in patients with autonomous cortisol secretion and Cushing syndrome

Astrom Ueland Grethe , Methlie Paal , Lovas Kristian , Saevik Ase Bjorvatn , Heie Anette , Sverre Husebye Eystein

Objective: Determine inflammatory and cardiometabolic biomarkers in patients with autonomous cortisol secretion (ACS), compared with healthy controls and patients with overt Cushing syndrome (CS).Method: Serum from prospectively included patients with ACS (n=65), overt CS (n=8), and healthy subjects (n=120) were analysed for 92 different inflammatory biomarkers using proximity extension assay.Results: ACS...

ea0063p426 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Validation of 24-hour human adrenal steroid rhythms measured by ULTRADIAN interstitial automated microdialysis: Comparison with plasma

Upton Thomas , Methlie Paal , Russell Georgina , Henne Nina , Tsagarakis Stelios , Kampe Olle , Lightman Stafford , Husebye Eystein

Background: Hormones oscillate in circadian and ultradian rhythms. Consequently, single time point measurements are very difficult to interpret. To address this, we developed an automated system of 24-hour ambulatory microdialysis. This allows measurement of free hormone concentrations in subcutaneous interstitial fluid collected while participants continue normal daily activities. To validate the technique for adrenal steroid hormones, we simultaneously sampled interstitial f...

ea0049ep33 | Adrenal cortex (to include Cushing's) | ECE2017

Rapid reduction in left ventricular mass in primary aldosteronism after treatment; a prospective cardiac MRI study

Grytaas Marianne Aardal , Sellevag Kjersti , Thordarson Hrafnkell Baldur , Husebye Eystein Sverre , Lovas Kristian , Larsen Terje Hjalmar

Background: Primary aldosteronism (PA) patients have increased left ventricular mass (LVM) and increased cardiovascular morbidity compared with those with essential hypertension. Echocardiographic studies have demonstrated that adrenalectomy or spironolactone decreases LVM. The aim of the present study was to use MRI to assess both LVM and cardiac function before and during stress testing, at baseline and after treatment with adrenalectomy or spironolactone, compared with heal...

ea0049ep49 | Adrenal cortex (to include Cushing's) | ECE2017

The short Synacthen test revisited – reevaluation of the normal reference range using LCMSMS

Ueland Grethe AEstrom , Methlie Paal , Oksnes Marianne , Lovas Kristian , Thordarson Hrafnkell , Husebye Eystein

Background: The Synachten test is used to diagnose for adrenal insufficiency (AI) and non-classical congenital adrenal hyperplasia (CAH). The cut-off levels for s-cortisol and s-17-hydroxyprogesterone are derived from immunoassays that were not well standardized and are no longer in use. Introduction of liquid chromatography tandem mass spectrometry (LCMSMS) could resolve the lack of standardization of steroid hormone assays and enable increased diagnostic accuracy.<p clas...

ea0049ep59 | Adrenal cortex (to include Cushing's) | ECE2017

Assay of steroids with Liquid chromatography tandem mass spectrometry is superior to immunoassays in monitoring patients with 21-hydroxylase deficiency

Nermoen Ingrid , Dahl Sandra Rinne , Brondstad Ingeborg , Husebye Eystein S , Thorsby Per M , Lovas Kristian

Objective: Immunoassays of steroids are still used in the diagnosis and biochemical monitoring of patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21 OHD). However, high levels of steroid intermediates can promote cross-reactivity between steroids giving rise to falsely elevated levels.Design: Fifty-nine patients with classic 21OHD (38 women) were studied. Blood samples were collected in the morning after overnight medicatio...

ea0044oc4.4 | Adrenal and Steroids | SFEBES2016

A Single Nucleotide Polymorphism in the BACH2 Gene Contributes to Susceptibility to Autoimmune Addison’s Disease in UK and Norwegian cohorts

Pazderska Agnieszka , Oftedal Bergithe , Napier Catherine , Ainsworth Holly , Husebye Eystein , Cordell Heather , Pearce Simon , Mitchell Anna

Background: Autoimmune Addison disease (AAD) is a rare but highly heritable endocrinopathy. The BACH2 protein plays a crucial role in T lymphocyte maturation, and in particular in regulatory T cell formation, and allelic variation in its gene has been associated with autoimmune conditions such as type 1 diabetes, autoimmune thyroid disease and vitiligo. Its role in susceptibility to autoimmune Addison’s disease (AAD) has not been investigated.Aim: T...