Endocrine Abstracts

Purpose: To study comparative influence of replacement GH therapy on a level of secretion of GH, IGF1 and IGFBP-3 in girls with endocrine and hereditary stunting.Materials and methods: Forty-six girls aged 5.5 to 17 were examined. Of them somatotropic insufficiency (STI) was found in 13 girls, multiple deficiency of adenohypophyseal hormones (MDAH) in 11, idiopathic nanism (IN) in 12, Turner syndrome (TS) in 10 girls. Patients received subcutaneous injec...

Goal: To study a frequency of occurrence and factors of progressive diabetic retinopathy (DR) in people with DM type 2 in Uzbekistan.Materials and study methods: Within the framework of WDF project ‘Prevention of blindness in people with diabetes mellitus in Uzbekistan’ granted to ‘UMID’ association in 2008, we carried out DR screening in people with DM type 2 in three pilot regions of Ferghana, Bukhara areas and the Republic of Karak...

Drying of the Aral Sea resulted in serious problems including pollution of air, water (mineralization of clear water) and soil which in its turn caused rise in various somatic diseases in population and produced a negative effect on health of children and adolescents.Purpose: To study the influence of ecologically adverse factors on physical and sexual development of children of the Aral Sea area.Drying of the Aral Sea resulted in ...

Diabetic retinopathy (DR) is one of the most frequent and serious complications of diabetes and the leading cause of blindness worldwide. Nevertheless, in Uzbekistan there is no precise statistical data on the prevalence of DR in patients with newly diagnosed diabetes mellitus.Purpose: To study the incidence of DR in newly diagnosed people with type 2 diabetes in Uzbekistan.Materials and methods: Within the framework of the grant &...

Goal: To carry out a retrospective analysis of case histories of children and adolescents with genetically determined types of short stature who admitted a paediatric department of a clinic of Research Institute of Endocrinologyduring 2003–2013.Materials and methods: An analysis of case histories of children and adolescents with short stature 3 to 17 years who undertook inpatient treatment in paediatric department of RIE clinic during 2003–2013...

Goal: Identification of latent mosaicism and determination of a parental origin of an X chromosome in TS patients in Uzbek population.Methods: Molecular genetic studies are carried out in 35 patients with TS (26 with monosomy and nine with mosaicism) at the age of 7–16 and their parents with a set of DIATOMTMDNA prep 200 reagents. DNA amplification was performed in Applied Biosystems thermocyclers. PCR products were subjected to electrophoresis on 1...

DM is a major cause of blindness, cardio-vascular risk the highest in the diabetics. More than 40% of all trauma-unrelated lower extremity amputations are performed because of diabetic foot syndrome (DFS) and lower extremity gangrene, 35–40% of all deaths due to uremia fall to the diabetics.Aim: To study DM late complications prevalence and risk factors contributing to their progression.Materials and methods: A total of 1000 a...

Diabetic foot syndrome (DFS) is currently considered the most severe of all late diabetes complications, resulting in deteriorating health outcomes, increased disability and reduced life expectancy.Aim: To study the frequency of occurrence of DFS in rural peoples with diabetes in Uzbekistan.Methods: Upon the international project WDF08-379 ‘Prevention of lower limb amputations in people with diabetes in Uzbekistan’, imple...

Of all the late complications of diabetes, foot lesions are the most preventable. The multidisciplinary approach to providing specialized help for people with diabetes can prevent the amputations in 49–85% diabetic foots.Aim: The organization of specialized help to patient with diabetic foot syndrome (DFS) by the establishing the network of ‘Diabetic foot’ rooms and training of multidisciplinary team of specialists (endocrinologist, surgeo...

Goal: Decrease a number of lower limb amputations in PDM in Uzbekistan by improvement of specialised help given to patients with DFS.Materials and methods: Prior to 2010 there were only 2 ‘Diabetic foot’ rooms in Tashkent, Uzbekistan. In 2010–2012, CPA ‘UMID’ jointly with Uzbekistan Ministry of Health and Research Centre for Endocrinology implemented a project ‘Prevention of lower limb amputations in people with diabetes mel...