Endocrine Abstracts

Introduction: The spectrum of GH deficiency (GHD) in children ranges from complete deficiency, with severe growth retardation, to partial deficiency, with slightly short stature. The administration of GH to children with GHD improves linear growth, mainly during the first 2 years of treatment.Patients and methods: The study analyzes pattern of growth in 35 children (24 boys, 11 girls) with GHD, in the first year of treatment with hGH. There were three gr...

Introduction: Myxedema coma (MC) is a rare life-threatening form of hypothyroidism most often seen in patients with incompletely treated or unknown hypothyroidism exposed to stressful conditions (surgery, infections, hypothermia, trauma).Case report: We report the case of a 58-years-old woman hospitalized for coma in a peripheral hospital after a severe respiratory infection. Two days after, patient’s condition was worsening and she was transferred ...

I fine-needle aspiration (FNA) is the gold standard in thyroid nodules management, but it is less common in the evaluation of parathyroid nodules. When imagery fails to localize a parathyroid adenoma, morphological and functional investigations, like FNA of the suspected area and scintigraphy may be useful. We present the case of a 58 years-old woman, menopaused at 47 years, who consulted for lombalgia. Vertebral DXA confirmed osteoporosis (Tscore −3.8). She was not trea...

Primary hyperparathyroidism (PHPT) is a relatively frequent problem in clinical endocrine practice. Minimally invasive parathyroid surgery is the treatment of choice but requires precise preoperatory localization. The most commonly investigation methods are ultrasonography and scintigraphy, but they are not always diagnostic. PTH assay of the aspirate from an ultrasound-guided fine-needle aspiration (USFNA) may confirm the location of pathological parathyroid tissue. The aim o...

Introduction: Pheochromocytoma and paraganglioma are catecholamine secreting tumours. Malignancy is uncommon (approximately 10% for pheochromocytoma and 20% for paraganglioma) and surgery, when possible, is the first line treatment. However, the prognosis is poor because of frequent local recurrence and/or metastases and the lack of specific chemotherapeutic agents. CASE-REPORT: We present the case of a 60 years-old man who, at the age of 48, was diagnosed with paraganglioma. ...

Calcitonin (CT) is a sensitive marker for medullary thyroid carcinoma, but its routine measurement in patients with thyroid nodules is a controversial issue. Generally, an elevated serum calcitonin strongly suggests the presence of medullary thyroid carcinoma (MTC); however high CT levels may be found in other thyroid or non-thyroidal conditions. We report the case of a 49-year-old woman who consulted at the ambulatory of endocrinology for recent thyroid soreness. Biological f...

Pancreatic neuroendocrine tumors (pNET) represent 1.3% of pancreatic tumours, ~65% patients presenting with metastatic/unresectable disease. Clinically, pNET may be asymptomatic, accompanied by carcinoid syndrome or abdominal pain.Patient N.A. aged 73, with a history of hemorrhagic pancreatitis, was diagnosed in 2003 with a hyperechoic heterogeneous solid pancreatic tumour of 28/28 mm. No therapy/monitoring were proposed. After 7 years of asymptomatic ev...

Pseudohypoparathyroidism (PHP) is an uncommon sporadic or inherited genetic disorder subdivided into several distinct entities characterized by parathyroid hormone (PTH) resistance in association with distinctive skeletal and developmental defects.We report a case of a 7 years and 8 months old boy, evaluated at the Endocrinology Department of ‘St Spiridon’ Hospital Iasi in January 2013, who had a history of hypothyroidism diagnosed at the age o...

Cyclic Cushing’s syndrome is a rare, probably under-reported disorder, characterized by repeated episodes of cortisol excess interspersed by periods of normal cortisol secretion, due to both ACTH-dependent and independent causes, and should be discerned from mild or subclinical Cushing’s syndrome and pseudo-Cushing’s states.We present a female patient 52 years old, with cyclic hypercortisolism clinically manifested and biologically confirm...

Background: Noonan syndrome (NS) is a genetic multisystemic disorder secondary to mutations in Ras/MAPK pathway, essential for cell’s differentiation and growth, patients associating short stature and skeletal anomalies. We describe the alterations in bone development and growth in five children with NS, four of which received treatment with recombinant human GH (rhGH).Methods: We reviewed the cases of five children with NS (three boys, two girls, a...