Searchable abstracts of presentations at key conferences in endocrinology

ea0032p903 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Efficacy of hGH treatment in pituitary dwarfism- age does matter

Idriceanu Jeanina , Vasiliu Ioana , Popovici Ramona , Bodescu Ioana , Rusu Cristina , Mogos Voichita , Vulpoi Carmen

Introduction: The spectrum of GH deficiency (GHD) in children ranges from complete deficiency, with severe growth retardation, to partial deficiency, with slightly short stature. The administration of GH to children with GHD improves linear growth, mainly during the first 2 years of treatment.Patients and methods: The study analyzes pattern of growth in 35 children (24 boys, 11 girls) with GHD, in the first year of treatment with hGH. There were three gr...

ea0026p430 | Thyroid (non cancer) | ECE2011

Improved prognosis in myxedema coma: happy ending of an old story: case report

Vasiliu Ioana , Preda Cristina , Grigoras Ioana , Florescu Alexandru , Balcan Roxana , Idriceanu Jeanina , Mogos Voichita , Vulpoi Carmen

Introduction: Myxedema coma (MC) is a rare life-threatening form of hypothyroidism most often seen in patients with incompletely treated or unknown hypothyroidism exposed to stressful conditions (surgery, infections, hypothermia, trauma).Case report: We report the case of a 58-years-old woman hospitalized for coma in a peripheral hospital after a severe respiratory infection. Two days after, patient’s condition was worsening and she was transferred ...

ea0022p107 | Bone/Calcium | ECE2010

Parathyroid FNA with PTH determination as a tool in primary hyperparathyroidism diagnosis – case report

Idriceanu Jeanina , Ionescu Lidia , Miron Claudia , Balcan Roxana , ElMekkaoui Safae , Vasiliu Ioana , Mogos Voichita , Vulpoi Carmen

I fine-needle aspiration (FNA) is the gold standard in thyroid nodules management, but it is less common in the evaluation of parathyroid nodules. When imagery fails to localize a parathyroid adenoma, morphological and functional investigations, like FNA of the suspected area and scintigraphy may be useful. We present the case of a 58 years-old woman, menopaused at 47 years, who consulted for lombalgia. Vertebral DXA confirmed osteoporosis (Tscore −3.8). She was not trea...

ea0022p118 | Bone/Calcium | ECE2010

Primary hyperparathyroidism diagnosis – new insights of an old dilemma

Vulpoi Carmen , Stefanescu Cipriana , Ionescu Lidia , Crumpei Felicia , Vasiliu Ioana , Balcan Roxana , Idriceanu Jeanina , Mogos Voichita

Primary hyperparathyroidism (PHPT) is a relatively frequent problem in clinical endocrine practice. Minimally invasive parathyroid surgery is the treatment of choice but requires precise preoperatory localization. The most commonly investigation methods are ultrasonography and scintigraphy, but they are not always diagnostic. PTH assay of the aspirate from an ultrasound-guided fine-needle aspiration (USFNA) may confirm the location of pathological parathyroid tissue. The aim o...

ea0022p428 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Malignant paraganglioma – the story of a long time survival

Balcan Roxana , Iliescu Dan , Stefanescu Cipriana , Popa Radu , Vasiliu Ioana , Idriceanu Jeanina , Zbranca Eusebie , Vulpoi Carmen

Introduction: Pheochromocytoma and paraganglioma are catecholamine secreting tumours. Malignancy is uncommon (approximately 10% for pheochromocytoma and 20% for paraganglioma) and surgery, when possible, is the first line treatment. However, the prognosis is poor because of frequent local recurrence and/or metastases and the lack of specific chemotherapeutic agents. CASE-REPORT: We present the case of a 60 years-old man who, at the age of 48, was diagnosed with paraganglioma. ...

ea0022p809 | Thyroid | ECE2010

Pitfalls in calcitonin measurement: case report

Vasiliu Ioana , Ciobanu Delia , Ungureanu Didona , Balcan Roxana , ElMekkaoui Safae , Idriceanu Jeanina , Mogos Voichita , Vulpoi Carmen

Calcitonin (CT) is a sensitive marker for medullary thyroid carcinoma, but its routine measurement in patients with thyroid nodules is a controversial issue. Generally, an elevated serum calcitonin strongly suggests the presence of medullary thyroid carcinoma (MTC); however high CT levels may be found in other thyroid or non-thyroidal conditions. We report the case of a 49-year-old woman who consulted at the ambulatory of endocrinology for recent thyroid soreness. Biological f...

ea0035p592 | Endocrine tumours and neoplasia | ECE2014

Pancreatic neuroendocrine tumour with a silent long evolution: case report

Manolachie Adina , Crumpei Felicia , Volovat Constantin , Bodescu Ioana , Idriceanu Jeanina , Vasiliu Ioana , Fadur Alina , Preda Cristina , Vulpoi Carmen

Pancreatic neuroendocrine tumors (pNET) represent 1.3% of pancreatic tumours, ~65% patients presenting with metastatic/unresectable disease. Clinically, pNET may be asymptomatic, accompanied by carcinoid syndrome or abdominal pain.Patient N.A. aged 73, with a history of hemorrhagic pancreatitis, was diagnosed in 2003 with a hyperechoic heterogeneous solid pancreatic tumour of 28/28 mm. No therapy/monitoring were proposed. After 7 years of asymptomatic ev...

ea0035p819 | Paediatric endocrinology | ECE2014

Pseudohypoparathyroidism: challenging diagnosis due to autism and epileptic seizures

Idriceanu Jeanina , Rusu Cristina , Bodescu Ioana , Vasiliu Ioana , Manolachie Adina , Fadur Alina Daniela , Preda Cristina , Mogos Voichita , Vulpoi Carmen

Pseudohypoparathyroidism (PHP) is an uncommon sporadic or inherited genetic disorder subdivided into several distinct entities characterized by parathyroid hormone (PTH) resistance in association with distinctive skeletal and developmental defects.We report a case of a 7 years and 8 months old boy, evaluated at the Endocrinology Department of ‘St Spiridon’ Hospital Iasi in January 2013, who had a history of hypothyroidism diagnosed at the age o...

ea0035p41 | Adrenal cortex | ECE2014

Periodic cushing's disease: difficult patient, difficult management

Vasiliu Ioana , Scripcariu Viorel , Poeata Ion , Bodescu Ioana , Idriceanu Jeanina , Manolachie Adina , Fadur Alina Daniela , Cristea Cristina , Mogos Voichita , Vulpoi Carmen

Cyclic Cushing’s syndrome is a rare, probably under-reported disorder, characterized by repeated episodes of cortisol excess interspersed by periods of normal cortisol secretion, due to both ACTH-dependent and independent causes, and should be discerned from mild or subclinical Cushing’s syndrome and pseudo-Cushing’s states.We present a female patient 52 years old, with cyclic hypercortisolism clinically manifested and biologically confirm...

ea0035p814 | Paediatric endocrinology | ECE2014

Differences in skeletal development and growth in children with Noonan syndrome

Fadur Alina Daniela , Rusu Cristina , Anton Mihaela , Bodescu Ioana , Manolachie Adina , Idriceanu Jeanina , Vasiliu Ioana , Ungureanu Maria-Christina , Mogos Voichita , Vulpoi Carmen

Background: Noonan syndrome (NS) is a genetic multisystemic disorder secondary to mutations in Ras/MAPK pathway, essential for cell’s differentiation and growth, patients associating short stature and skeletal anomalies. We describe the alterations in bone development and growth in five children with NS, four of which received treatment with recombinant human GH (rhGH).Methods: We reviewed the cases of five children with NS (three boys, two girls, a...