Searchable abstracts of presentations at key conferences in endocrinology

ea0056mte12 | (1) | ECE2018

Controversies in NETs: Is high dose SSA treatment relevant and who needs hemicolectomy?

Kaltsas Gregory

Long-acting somatostatin analogs (SSAs) have long been used for symptom control in patients with functional neuroendocrine tumors (NETs) whereas two recent prospective studies (PROMID and CLARINET) have demonstrated their efficacy in controlling tumor growth in patients with gastrointestinal NETs of different tissue origin. For both purposes currently available agents (octreotide LAR 10–30 mg i.m and lanreotide autogel 60–120 mg s.c.) have been used. In case of refra...

ea0035mte16 | (1) | ECE2014

Postmenopausal hyperandrogenism

Kaltsas Gregory , Markopoulos Marios

Menopause is a state of relative hyperandrogenism resulting from the abrupt fall of estrogen levels due to ovarian senescence and the steady decline of androgen levels with aging. Frank hyperandrogenism, characterized by hyperandrogenemia and clinical hyperandrogenism, in postmenopausal women is most commonly the result of functional causes of hyperandrogenism, which usually pre-exist menopause from early reproductive years, and are aggravated by the physiological changes of m...

ea0055cb5 | Additional Cases | SFEEU2018

Post-operative hypocalcaemia in a patient with a metastatic pancreatic neuroendocrine tumour

Sukumar Nithya , Kaltsas Gregory , Weickert Martin

Case history: Mrs SC, a 56 year old female was referred to the endocrine registrar with hypocalcaemia (corrected calcium 1.93 mmol/l). She was day 3 post-hemihepatectomy for liver metastases from a primary pancreatic tail neuroendocrine tumour (NET). She had paraesthesia and numbness of her fingers and toes but no spasms. Chvostek’s sign was negative and there were no ECG changes. Past medical history includes severe hypercalcaemia in September 2016 which...

ea0048o7 | Oral Communications | SFEEU2017

Hypertestosteronemia and primary infertility due to an extragonadal germ cell tumor of the anterior mediastinum

Dimitriadis Georgios K , Kaltsas Gregory , Randeva Harpal S

A 26-year-old Caucasian male presented to the joint infertility outpatients clinic with primary infertility. His medical history included hypertrophic cardiomyopathy (HCM) due to genetically confirmed MYH7 sarcomere protein mutation, treated with implantable cardioverter-defibrillator while his partner was a healthy 24-year-old Caucasian nulliparous female. Initial investigations showed hypertestosteronemia (Testosterone: >51.0 nmol/l) and azoospermia, hence the c...

ea0044p114 | Diabetes and Cardiovascular | SFEBES2016

The impact of thyroid autoimmunity on insulin secretion in pre-diabetic patients with normal thyroid function

Alexandraki Krystallenia , Liatis Stavros , Kaltsas Gregory , Boutzios Georgios

Introduction: Autoimmune thyroid disease (AITD) and abnormal carbohydrate metabolism are the commonest endocrine disorders in the general population. However, the effect that AITD may exert in β-cell secretion and insulin action in patients pre-diabetes has not been investigated before.Methods/design: One hundred and eighty-two patients (157 females) 46.5±14.2 years with pre-diabetes (impaired fasting glucose (IFG) or/and impaired glucose toler...

ea0099p99 | Endocrine-Related Cancer | ECE2024

Metastatic paragangliomas – real world data in a single tertiary center

Thanasoula Foteini , Vlachou Sofia , Kassi Evanthia , Angelousi Anna , Kaltsas Gregory

Background: Paragangliomas(PGLs) and pheochromocytomas (PHEOs) are rare extra-adrenal neuroendocrine tumors of the sympathetic and parasympathetic nervous system. Metastatic status is defined by the abnormal presence of non-chromaffin tissue in extra adrenal organs. The incidence of metastases rises up to 10–17% and may appear even 10 years after the initial diagnosis.Methods: We retrospectively analysed medical files of patients followed in a terti...

ea0081p641 | Endocrine-Related Cancer | ECE2022

Management and long term follow up of hyperparathyroidism in multiple endocrine neoplasia type 1: single center experience

Yavropoulou Maria , Vlachou Sofia , Tsoli Marina , Fostira Florentia , Kaltsas Gregory , Kassi Eva

Background and objective: Multiple Endocrine Neoplasia type 1 (MEN 1) is an autosomal dominant disease characterized by a broad clinical spectrum. Previous multi-center studies, that analyzed large groups of patients with MEN 1 have been reported before but long term follow up data of these patients focusing exclusively on primary hyperparathyroidism (PHPT) are scarce.Patients and Methods: In this retrospective cohort study we include all patients with P...

ea0081ep590 | Endocrine-Related Cancer | ECE2022

Pheochromocytomas and paragangliomas-real world data in a tertiary Greek center

Thanasoula Foteini , Angelousi Anna , Kyriakopoulos Georgios , Yavropoulou Maria , Kassi Evanthia , Kaltsas Gregory

Purpose: Pheochromocytomas (PCs) and paragangliomas (PGLs) are rare neuroendocrine tumors arising from chromaffin cells of the adrenal medulla and the sympathetic/parasympathetic neural ganglia, respectively. Metastatic PCs/PGLs occur in about 5-26% of cases. Their management and diagnosis still remain a challenge due to their heterogeneity, the absence of guidelines and the few prognostic tools.Aim: The aim of this study was to describe clinical and gen...

ea0081ep751 | Pituitary and Neuroendocrinology | ECE2022

Immunohistochemichal expression of ephrin receptor (EPH)-A4, -A5, -B2 and -B5 in pituitary lesions

Papadimitriou Eirini , Kyriakopoulos Georgios , Barkas Konstantinos , Gkalonakis Ioannis , Pantoula Panagiota , Theocharis Stamatios , Kaltsas Gregory , Alexandraki Krystallenia

Introduction: Ephrin receptors (EPHs) compose the largest known subfamily of receptors tyrosine kinases and are bound and interact with EPHs-interacting proteins (Ephrins). They have a role in tumor growth, invasion, angiogenesis and metastasis of several neoplasms. Aim of the study was to investigate the expression of EPH-A4, -A5, -B2 and -B5 in pituitary lesions. Material and Methods: Our study group consisted of 18 patients (9 males with median age 54...

ea0063p877 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Accuracy of adrenal imaging studies in predicting histological tumor dimension following adrenalectomy

Alexandraki Krystallenia , Aggeli Chrysanthi , Antonopoulou Ioanna , Parianos Christos , Ntokos George , Pateas Konstantinos , Kaltsas Gregory , Zografos Georgios

Introduction: Although computed tomography (CT) is the best mean to identify adrenal neoplasms there is still controversy of the concordance of the estimated radiological and histological size of the lesion. Since the size of adrenal tumours is a major criterion for surgical excision, we investigated whether recent and more sophisticated imaging techniques, can more accurately predict tumor’s size.Methods: We have retrospectively analyzed a series o...