Searchable abstracts of presentations at key conferences in endocrinology

ea0029p279 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Gastrectomy for early gastric cancer is associated with decreased cardiovascular mortality in accordance with amelioration of metabolic abnormalities, visceral adiposity and atherosclerosis

Lee Y. , Han S. , Kim H. , Hyung W. , Lim J. , Lee K. , Lee H. Lee E. , Kang E. , Ahn C. , Cha B. , Lee H.

Objectives: We investigated cardiovascular and all-cause mortality in patients who underwent gastrectomies for early gastric cancer (EGC), and analyzed the changes in metabolic parameters in these patients after surgery.Background: Bariatric surgery, including gastric banding and gastric bypass, effectively induces weight loss and resolves cardiovascular comorbidities in obese patients.Methods: 2477 patients who underwent gastrecto...

ea0029oc17.4 | Diabetes Basic | ICEECE2012

Syntaxin-3 regulates recruitment and exocytosis of newcomer insulin granules and granule-granule fusion during biphasic glucose-stimulated insulin secretion in pancreatic β-cells

Zhu D. , Koo E. , Kwan E. , Kang Y. , Park S. , Xie H. , Sugita S. , Gaisano H.

Introduction: The molecular basis of exocytosis of secretory insulin-containing granules (SGs) during biphasic glucose-stimulated insulin secretion (GSIS) of pancreatic β-cells remains unclear. Syntaxins (Syns) Syn-1A and Syn-4 are t-SNARE proteins situated on the plasma membrane that have been well studied to mediate insulin exocytosis. However, Syn-3, peculiarly more abundant in insulin SGs, has unclear function in GSIS.Methods/Designs: Confocal m...

ea0081ep427 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The role of deferoxamine (DFO) in insulin resistance and diabetes

Ahn So-Yeon , Woo Song Min , Yeop Jeong Jae , Ho Kim Tae , Choi Sung-E , Kang Yup , Jin Kim Hae , Young Jeon Ja , JIN Han Seung , Lee Nami , Lee Kwan-Woo

Iron also plays an important role in many physiological processes, including redox balance, inflammation, and metabolism. It is reported perturbation of iron (Fe) homeostasis has also been associated with metabolic diseases. Iron reduction, with iron chelator, has preventive effects in cardiovascular remodeling and obesity. On the other hand, deferoxamine (DFO) increases hypoxia and collagen production in the kidney. Thus, the effects of DFO on metabolic disease remains contro...