Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep293 | Clinical case reports - Pituitary/Adrenal | ECE2016

Ectopic prolactin-secreting adenoma at the pituitary stalk

Schilbach Katharina , Schopohl Jochen

Almost all cases of prolactinomas are benign intrasellar micro- or macroadenomas. Very rarely benign prolactinomas are located outside the sella and in most of these cases the tumors are located in the sphenoidal sinus.We here report a 35 year old woman who presented to the clinic with secondary amenorrhoea and galactorrhoea. Initial laboratory testing revealed mild hyperprolactinemia between 1100 and 1600 μU/ml and hypogonadotropic hypogonadism wit...

ea0063p252 | Pituitary and Neuroendocrinology 1 | ECE2019

A case of ‘micromegaly’: need for revision of oral glucose tolerance test (OGTT) cut-offs with modern growth hormone assays in acromegaly

Schilbach Katharina , Stormann Sylvere , Bidlingmaier Martin , Schopohl Jochen

The OGTT is the gold standard for confirmation or exclusion of acromegaly in treatment-naïve patients as well as after surgery. According to former guidelines, acromegaly is ruled out if the growth hormone (GH) nadir lies below 1.0 μg/l and 0.4 μg/l pre- and postoperatively, respectively. We present the case of a 40-year-old man who presented to the outpatient clinic in 2014 for endocrinological evaluation after an elevated IGF-I concentration had occasionally b...

ea0056p707 | Clinical case reports - Pituitary/Adrenal | ECE2018

Atypical pituitary adenoma: a case of histological mimicry

Schilbach Katharina , Saeger Wolfgang , Stormann Sylvere , Schopohl Jochen

We present the case of a 67-year-old man who presented to the outpatient clinic for endocrinological evaluation after partial resection of an atypical pituitary adenoma (APA). Pathohistological assessment of two independent and experienced neuropathologists resulted in a diagnosis of APA with unusually high proliferation indices (Ki67 10–20%/p53 30%) and immunoreactivity for LH, FSH and the alpha-subunit. Clinical examination as well as laboratory testing revealed no sign...

ea0081ep692 | Pituitary and Neuroendocrinology | ECE2022

Soluble alpha klotho in blood is a new and highly stable biomarker

Ribeiro de Oliveira Longo Schweizer Junia , Haenelt Michael , Schilbach Katharina , Stormann Sylvere , Schopohl Jochen , Bidlingmaier Martin

Background: Soluble alpha klotho (sαKL) is a circulating protein that has been linked to the growth hormone (GH) axis. We previously showed its association to disease activity in patients with acromegaly, with considerable robustness towards biological confounders. However, there is scarce data in literature regarding the analytical performance of the assay, and pre-analytical stability of sαKL in blood samples. Objective: We aimed to evaluate ...

ea0090ep761 | Pituitary and Neuroendocrinology | ECE2023

Delayed onset of pasireotide-induced hyperglycemia: Report of two cases

Stormann Sylvere , Schilbach Katharina , Amereller Felix , Schweizer Junia Ribeiro de Oliveira Longo , Schopohl Jochen

Introduction: Pasireotide is a potent somatostatin analogue (SSA) and used in therapy-refractory acromegaly, commonly after failure of treatment with first-generation SSA. However, it may induce severe hyperglycemia, which usually occurs rapidly after initiation of therapy and in general gradually improves over time. We here present two cases of young male patients who developed severe pasireotide-induced hyperglycemia after several years of treatment.Ca...

ea0049ep639 | Growth hormone IGF axis - basic | ECE2017

Modulation of the 22 kD/20 kD growth hormone (GH) ratio by exercise, fasting and glucose load in premenopausal women

Haenelt Michael , Schilbach Katharina , Gar Christina , Lechner Andreas , Schwaiger Rita , Bidlingmaier Martin

We previously have shown in a cohort of 236 non-fasted women that before and after a short high intensity exercise protocol (HIP) till exhaustion serum concentrations of 20 and 22 kD growth hormone (hGH) are highly correlated (P<0.0001). Although the GH response to exercise exhibited huge inter-individual differences, the 20 kD/22 kD-GH-ratio remained unchanged (9.6% vs 11.1%, P=0.313). A subgroup of the women was also studied under fasted conditions in a...

ea0049ep1027 | Pituitary - Clinical | ECE2017

Potassium homeostasis in patients with acromegaly in comparison with hypertensive patients

Stormann Sylvere , Schilbach Katharina , Pichl Christine , Kosilek Robert P , Anders Hans-Joachim , Schopohl Jochen

Introduction: Acromegaly is characterized by chronic growth hormone (GH) excess and leads to numerous changes in bodily functions and comorbidity. We compared potassium homeostasis in patients with acromegaly to hypertensive controls.Methods: We prospectively assessed serum potassium, urinary potassium excretion, aldosterone and renin, acid-base balance as well as glomerular filtration rate according to the CKD-EPI formula in 71 patients with acromegaly ...

ea0070aep667 | Pituitary and Neuroendocrinology | ECE2020

Gender differences in airway obstruction in men and women with acromegaly: A longitudinal study

Störmann Sylvère , Schilbach Katharina , Amereller Felix , W Angstwurm Matthias , Schopohl Jochen

Introduction: Acromegaly is a slowly progressing systemic disease that leads to numerous changes in metabolism and organ function. A large cross-sectional study showed signs of subclinical airway obstruction in female patients. We performed a longitudinal study of lung function testing to compare parameters of airway obstruction in male and female patients with acromegaly over time.Methods: 40 patients with acromegaly (24 male, 16 female) underwent repea...

ea0081p660 | Pituitary and Neuroendocrinology | ECE2022

Soluble alpha klotho in adult patients with growth hormone deficiency

Ribeiro de Oliveira Longo Schweizer Junia , Schilbach Katharina , Haenelt Michael , Gagliardo Anica , Stormann Sylvere , Schopohl Jochen , Bidlingmaier Martin

Background: We recently have shown a close association of high concentrations of soluble alpha klotho (sαKL) to disease activity in acromegaly. Small pilot studies suggested that sαKL concentrations might be reduced in GH deficiency (GHD) and increase after recombinant human GH (rhGH) therapy. Our aim was to evaluate the potential of sαKL as a biomarker in GHD.Methods: We evaluated sαKL in comparison to the classical biomarkers GH, IG...

ea0049gp196 | Pituitary &amp; endocrine Tumours | ECE2017

Diagnosis of acromegaly: Sex and BMI are the major determinants of growth hormone suppression during oral glucose tolerance test (OGTT)

Schilbach Katharina , Nicolay Shiva Sophia , Haenelt Michael , Lechner Andreas , Gar Christina , Schopohl Jochen , Stormann Sylvere , Schwaiger Rita , Bidlingmaier Martin

GH suppression during OGTT is the gold-standard test in diagnosis and monitoring of acromegaly. However, discrepancies between GH nadir and IGF-I have been described and have triggered search for factors modifying the extent of GH suppression. Cut-offs at 1.0 or 0.4 ng/ml are currently recommended with modern, highly sensitive GH assays. To establish assay specific GH nadir cutoffs for the 22kD GH specific IDS-iSYS assay, we examined 381 subjects (319 females, 62 males) with n...