Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep844 | Reproductive and Developmental Endocrinology | ECE2020

Severe hyperandrogenaemia and unusually large polycystic ovaries: A case report

Khan Uzma , Randeva Harpal

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of young women and depending on the diagnostic criteria, it affects 6% to 20% of reproductive aged women. PCOS is also the most common cause of hyperandrogenism in young women with the theca cells of the ovary being the source of androgen excess. PCOS is rarely associated with severe hyperandrogenaemia and atypical features such as rapid progression, presence of virilization or very high Testo...

ea0065p329 | Neuroendocrinology | SFEBES2019

CNS lymphoma masquerading as pituitary macroadenoma

Khan Uzma , Borg Anton , Beltechi Radu , Mehta Hiten , Smith Megan , Randeva Harpal , Machenahalli Pratibha

Introduction: Non-Hodgkin lymphoma (NHL) involving the hypothalamus and pituitary gland is rare. Central nervous system involvement by NHL may be either as a primary tumour or from systemic lymphoma. We report an interesting case of aggressive central nervous system (CNS) lymphoma presenting as pituitary macroadenoma.Case report: A 67-year-old Caucasian woman presented with sudden onset of left eye ptosis and diplopia. Examination showed left third nerve...

ea0044p59 | Bone and Calcium | SFEBES2016

Primary hyperparathyroidism and concomitant vitamin D deficiency: Study of diagnosis and management outcomes

Khan Uzma , Al-Sharefi Ahmed , Partha Praveen , Kamaruddin Shafie , Tarigopula Giridhar , Peter Paul

Introduction: Primary hyperparathyroidism (PHPT) is the third most common endocrine disorder; its evaluation includes biochemical investigations and imaging studies prior to surgical intervention. Imaging is advised as an aide to surgery and not for diagnostic purposes. Coexistence of PHPT and vitamin D deficiency is common; however, the exact nature of the relationship (causal vs secondary) is not clear.Subject and methods: We conducted a retrospective ...

ea0041ep264 | Clinical case reports - Pituitary/Adrenal | ECE2016

The endocrine trifecta: rarer presentation of a rare disease

Khan Uzma , Al-Sharefi Ahmed , Peter Paul , Kamaruddin Shafie , Tarigopula Giridhar , Partha Praveen

Introduction: Autoimmune polyendocrine syndrome type 2 is a rare disease characterized by the presence of autoimmune Addison’s disease in combination with thyroid autoimmune disease and/or type 1 diabetes mellitus, and possible occurrence of other autoimmune non-endocrine disorders. The combination of the three glands diseases is even rarer and is referred to as Carpenter’s syndrome.A long time interval is often present between the manifestatio...

ea0075m12 | Metabolic Bone | EYES2021

Management considerations for adults with x-linked hypophosphatemia: A case report

Thadani Puja , Khan Uzma , Murthy Narasimha , Rao Ranganatha , Sankar Sailesh , Randeva Harpal

Background: X-linked hypophosphatemia (XLH) is a rare, hereditary, progressive musculoskeletal disorder. Prompt diagnosis and treatment in childhood ensures adequate bone matrix mineralization and skeletal growth. There is no consensus on indications for treatment in adult patients.Case Presentation: A 25 year old female was referred to endocrinology with a right ankle fragility fracture. She was known to have XLH, diagnosed in Poland at the age of 1 yea...

ea0075p07 | Pituitary and neuroendocrinology | EYES2021

Pregnancy and diabetes insipidus – A management conundrum

Thadani Puja , Khan Uzma , Giovos Georgios , Smith Megan , Dhingra Vandana , Shad Amjad , Randeva Harpal , Machenahalli Pratibha

Background: Diabetes Insipidus (DI) is uncommon during pregnancy. It may predate pregnancy, be unmasked by pregnancy or arise de novo during pregnancy secondary to other pathology. We present a case of DI in pregnancy to highlight challenges in management.Case Report: A 27-year-old lady at 21 weeks’ gestation, presented to A&E with worsening headache and confusion for three to five months. She was hemodynamically stable, had bitemporal hemianopi...

ea0077p99 | Neuroendocrinology and Pituitary | SFEBES2021

Retrospective audit of clinical, biochemical and radiological features of Pituitary apoplexy

Machenahalli Pratibha , Shad Amjad , Shrelala Khalid , Thandani Puja , Giovos Georgios , Khan Uzma , Page Tristan , Haris Faiza , Smith Megan , Randeva Harpal

Background: Pituitary apoplexy is one of the rare endocrine emergencies. Most series indicate that incidence is between 2-7% based on clinical, surgical and histopathological evidence.1-3 Usually presents with severe headaches that may be associated with nausea vomiting, ocular palsies, fever, photophobia. Predisposing factors are pre-existing pituitary conditions, hypertension, major surgery, anticoagulation therapy, pregnancy, radiotherapy. Appropriate endocrine, ...

ea0065p239 | Metabolism and Obesity | SFEBES2019

Weight loss and change in obesity related comorbidities in patients undergoing laparoscopic adjustable gastric banding at UHCW between 2009 and 2012

Leca Bianca , Dimitriadis Georgios K , Khan Uzma , Abraham Jenny , Halder Louise , Shuttlewood Emma , Shah Neha , Barber Thomas M , Menon Vinod , Randeva Harpal S

Background: The Royal College of Physicians (RCP) called earlier this year for obesity to urgently be recognized as a disease, and warned that until this happens its prevalence is unlikely to be reduced. Obesity is associated with multiple comorbidities, including type 2 diabetes mellitus (T2DM), hypertension (HT), and dyslipidemia. Bariatric surgery (BS) produces dramatic weight loss, with improvement of obesity associated comorbidities and decrease of overall mortality.<...