Endocrine Abstracts

Introduction: The simultaneous occurrence of central hyperthyroidism and primary hyperparathyroidism is extremely rare. Few cases of TSH pituitary adenoma in the setting of multiple endocrine neoplasia type 1-associated syndrome were reported in literature. Herein, we report a new case of TSH secreting pituitary adenoma particular by the coexisting of primary hyperparathyroidism and vitamin D deficiency.Observation: A 76-year-old woman was referred to ou...

We report a retrospective study of 50 cases of primary hyperparathyroidism (10 men and 40 women, mean age: 49 years) collected between 1975 and 2004. At the time of diagnosis, 44% of patients had bone disease, renal manifestations were present in 17 cases (34%).Parathyroidectomy is a safe and effective approach of primary hyperparathyroidism treatment. The management of persistent or recurrent hyperparathyroidism is explained by the fact that parathyroid...

The frequency of type 2 diabetes increases in all of the world. The risk for atherosclerosis vascular disease is greatest in type 2 diabetic patients who have other known risk factors such obesity, smoking, hypertension and dyslipidemia.The aim of our study is to determine the frequency of cardiovascular risk factors associated to diabetes and the frequency of macrovascular complications in type 2 diabetic patients.It is a retrospe...

Prolactinoma represents 27 to 35% of pituitary adenomomas and 40 to 75% of secreting adenomas. However, the macroprolactinomas are not frequent. We report clinical, biological and therapeutic aspects of 5 cases of macroprolactinomas. It concerns 3 women and 2 men. The average age is 43.4 years (19–68). The reason for seaking medical advice was amenorrhea – galactorrhea syndrom in 2 women and infertility in one case. The diagnosis of pituitary adenoma is incidentally ...

Background and aims: Diabetes causes tissue fibrosis by still poorly understood mechanisms which involve glycation products. Galectin-3 (Gal-3) is an emerging key player in metabolic disorders and a powerful factor in the development and progression of the fibrotic process in target organs in diabetic patients. The plasma level of Gal-3 increases during diabetic cardiomyopathy and diabetic nephropathy. We have studied the correlation between serum Gal-3 level and anti-diabetic...

Background and aims: Plasma Galectin-3 (Gal-3), mediator of fibrogenesis and inflammation, has been implicated in many diseases. Particularly in diabetics, this lectin directly mediates transdifferentiation in collagen-producing cells thus leading to fibrosis of target organs and accelerating the development of complications. The objective of our study was to determine a cut-off value for Gal-3 in our population.Methods: We conducted a cross-sectional, a...

Introduction: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is the most common of the CAH, it is also the most common of the autosomal recessive diseases. Hypertension is generally absent, and its presence should lead to an investigation of another cause.Observation: We report the case of a 26-year-old young man, descendant from a second-degree consanguineous marriage with a family history of the death of a brother at the age of 2...

Introduction: Primary hyperparathyroidism (pHPT) is a common endocrine disorder usually diagnosed by the presence of elevated serum calcium levels with inappropriate normal or increased parathyroid hormone (PTH) serum levels. This condition has been reported in few cases of patients with sickle cell disease (SCD), a multisystem disorder with acute and chronic complications.Observation: We report a case of a 63-year-old Tunisian woman with a history of ho...

Introduction: Postoperative hypoparathyroidism is a frequent complication of total thyroidectomy that must be detected and treated. The resulting hypocalcemia is quite severe and usually occurs in the first few days or weeks after surgery.Herein, we describe a case of chronic asymptomatic hypocalcemia related to postoperative hypoparathyroidism diagnosed years after total thyroidectomy.Observation: We report the case of a 61 year old woman, who had a tot...

Introduction: Primary hyperparathyroidism is associated with multiple complications: severe bone disease is one of them. Osteomalacia is by definition a metabolic bone disease characterized by a softening of the bones. We herein report a rare case of an association between primary hyperparathyroidism with osteitis fibrosa cystica and osteomalacia caused by a severe vitamin D deficiency.Observation: A 37-year old woman was referred for investigation of we...