Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep482 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effect of laparoscopic mini-gastric bypass on the compensation of carbohydrate metabolism in patients with morbid obesity and type 2 diabetes

Mazurina Natalya , Ershova Ekaterina , Komshilova Kseniya , Kim Ekaterina

Objective: Sustained weight loss is a highly effective strategy to treat and prevent the development of type 2 diabetes (T2D). Bariatric surgery leads to significant weight loss, which ensures the achievement of remission of diabetes mellitus and other obesity-related comorbidities. AimThe aim of this study was to estimate glycemic profile of patients with morbid obesity and T2D after laparoscopic mini-gastric bypass (LMGB). MethodsWe conducted a retrospective study of ob...

ea0090ep583 | Endocrine-related Cancer | ECE2023

Recurrent parathyroid cancer in a child associated with mutation in CDC73 gene

Kim Ekaterina , Krupinova Julia , Eremkina Anna , Kalinchenko Natalya , Mokrysheva Natalia

Background: Parathyroid cancer (P?) in children is extremely rare, more often sporadic, but may be associated with a germline mutation. The only effective treatment is surgical approach due to the chemo-radio-resistance of PC.Clinical case: A 6-years-old girl presented with weakness, gait disturbance, pain in the limbs, an X-shaped curvature of the legs. At the age of 12, the patientÂ’s well-being worsened sharply. The laboratory examination revealed...

ea0090ep579 | Endocrine-related Cancer | ECE2023

Mathematical model for preoperative differential diagnosis for the parathyroid neoplasms

Krupinova Julia , Elfimova Alina , Kim Ekaterina , Eremkina Anna , Maganeva Irina , Kovaleva Elena , Mokrysheva Natalia

Backgrounds: Preoperative diagnosis of parathyroid carcinoma (PC) is critical for the determination of the scope of surgical intervention. Nowadays, specific diagnostic markers for differentiation of PC and benign tumors are unknown, and less than half of patients with PC undergo necessary en bloc surgery.Aims: To develop the instrument for preoperative diagnosis of PC.Materials and methods: A multi-center retrospective study inclu...

ea0090ep586 | Endocrine-related Cancer | ECE2023

Parathyroid carcinoma in a patient with both MEN1 and RET mutations

Pylina Svetlana , Kim Ekaterina , Bondarenko Ekaterina , Krupinova Julia , Eremkina Anna , Mokrysheva Natalia

Background: MEN1-related primary hyperparathyroidism (PHPT) characterised by benign course, whereas malignant transformation is extremely rare. The diagnosis of parathyroid carcinoma (PC) within the MEN-1 syndrome is a challenge for a range of specialists.Clinical case: A 47-year Eastern European female. PHPT had been revealed during examination for multinodular goitre: PTH 614 nmol\l, calcium 3.06 mmol\l. Results of imaging methods were controversial (m...

ea0090ep584 | Endocrine-related Cancer | ECE2023

Patient-derived three-dimensional model of papillary thyroid cancer for personalized medicine and testing of novel therapies

Petrova Daria , Bastrich Asya , Abilov Zaur , Bondarenko Ekaterina , Urusova Liliya , Nikiforovich Petr , Belcevich Dmitry , Pylina Svetlana , Eremkina Anna , Kim Ekaterina , Mokrysheva Natalia

Introduction: Over the last decades, there has been a significant increase in the incidence of thyroid cancer. Papillary thyroid cancer (PTC) is the most common histopathological type with often a favorable prognosis. Conventional therapies include surgical resection, adjuvant therapy with radioactive iodine, and suppressive therapy with thyroid hormones. However, the prognosis for iodine-resistant/refractory thyroid cancers or the advanced metastatic cancer is less favorable....