Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep22 | Adrenal cortex (to include Cushing's) | ECE2016

Method-specific serum cortisol responses to the ACTH test: comparison of two generations of Roche automated immunoassays using polyclonal vs MABs

Klose Marianne , Hilsted Linda , Feldt-Rasmussen Ulla

Introduction: The plasma cortisol response to the ACTH test is known to vary significantly by assays. An automated cortisol immunoassays with increased specificity due to the shift from polyclonal to MABs, and standardized against mass spectrometry was recently introduced, with an expected decrease in cortisol concentrations by 20%. Cut-offs used in clinical practice for patient evaluation will thus have to be adjusted. We aimed to assess the normal cortisol response to ACTH s...

ea0041gp58 | Cardiovascular endocrinology | ECE2016

Cardiac status after long-term growth hormone replacement therapy in adult growth hormone deficient patients. A single centre audit based on echocardiographic investigations before and during GH replacement therapy

Skoglund Sissela , Rasmussen Ulla Feldt , Klose Marianne , Hassager Christian

Objective: To determine the effects of long-term growth hormone (GH) treatment on heart anatomy and function among adult GH deficient patients.Design: A retrospective observational study at Copenhagen University Hospital, Rigshospitalet, Denmark between 1999 and 2015.Patients: All patients with available echocardiography data at treatment baseline, 3–5 years and 8–10 years follow up. We included 25 naïve GH deficient...

ea0035p902 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Prolactin hyperproduction does not predict the risk of glucose metabolic disturbances in patients with acromegaly

Erichsen Trine Moeller , Klose Marianne , Broholm Helle , Feldt-Rasmussen Ulla

Hypothesis and aim: Acromegaly is frequently associated with impaired glucose tolerance and diabetes, and concomitant hyperprolactinaemia was suggested to add to this effect. We hypothesized that pituitary prolactin (PRL) histopathology and plasma hyperprolactinaemia has a prognostic value in predicting the risk of glucose metabolic disturbances in acromegalic patients. The aim of this study was to examine glucose metabolic outcomes in acromegalic patients with and without his...

ea0016p464 | Neuroendocrinology | ECE2008

Posttraumatic hypopituitarism is associated with an unfavorable body composition and lipid profile, and decreased quality of life 12 months after injury

Klose Marianne , Watt Torquil , Brennum Jannick , Feldt-Rasmussen Ulla

Objective: To describe body-composition, lipid profile, and health-related quality of life (HRQL) in patients with traumatic brain injury (TBI) in relation to the development of posttraumatic hypopituitarism.Design: Cross-sectional with a nested prospective sub-study.Patients: The cross-sectional cohort included 104 hospitalized patients with TBI (26F/78M; age: median 41 years (range 18–64); BMI: 25 kg/m2 (17–3...

ea0063p1108 | Pituitary and Neuroendocrinology 3 | ECE2019

Variability of momentarily measured fatigue in patients with pituitary insufficiency receiving hydrocortisone replacement therapy

Boesen Victor Brun , Watt Torquil , Borresen Stina Willemoes , Klose Marianne , Feldt-Rasmussen Ulla

Background: Secondary adrenal insufficiency is usually treated with hydrocortisone replacement therapy twice or thrice daily in varying doses to mimic the physiological rhythm of cortisol release. However, despite efforts to optimize treatment regimens patients report impaired quality of life (QoL), including important aspects such as fatigue. A possible explanation is a suboptimal imitation of cortisol release resulting in an inadequate substitution at certain times during th...

ea0041ep904 | Pituitary - Clinical | ECE2016

Subarachnoid haemorrhage results in poor quality of life independent of pituitary hormone concentrations

Nagras Zainab , Klose Marianne , Poulsgaard Lars , Kosteljanetz Michael , Brennum Jannick , Feldt-Rasmussen Ulla

Introduction: Subarachnoid haemorrhage (SAH) is associated with a mortality rate of 30% and the survivors face significant morbidity including fatigue, isolation, depression and sleep disorders; factors affecting general health related quality of life (QoL). QoL is also known to be decreased in pituitary-hypothalamic insufficiency and tends to improve after treatment. SAH has been suggested to be a common cause of hypopituitarism by some whereas not by others. We aimed to inve...

ea0070aep740 | Pituitary and Neuroendocrinology | ECE2020

The effect of dual-release versus conventional hydrocortisone on fatigue, measured by ecological momentary assessments

Boesen Victor , Borresen Stine , Christoffersen Thea , Klose Marianne , Watt Torquil , Feldt-Rasmussen Ulla

Background: Replicating the physiological cortisol secretion is key in treatment of glucocorticoid insufficient individuals. A sub-optimal replication may explain the impaired quality of life experienced by these individuals. The study investigates fatigue measured by ecological momentary assessments in patients treated with conventional hydrocortisone compared with a once-daily dual-release formula of hydrocortisone (Plenadren) that follows the cortisol physiology more closel...

ea0032p688 | Neuroendocrinology | ECE2013

The characterization of sleep–wake pattern and its association with melatonin, as a marker of the circadian function of the suprachiasmatic nucleus, in craniopharyngioma patients

Jakobsen Line Pickering , Jennum Poul , Gammeltoft Steen , Feldt-Rasmussen Ulla , Klose Marianne

Hypothesis: We hypothesised that damage to the hypothalamus by local tumour, surgical treatment, or irradiation might involve the suprachiasmatic nucleus and thereby melatonin secretion, leading to disturbed circadian function and clinical manifestations such as daytime sleepiness and fatigue in craniopharyngeoma patients.Objective: We aimed to assess the influence of craniopharyngiomas and their treatment on melatonin secretion, sleep pattern, sleep qua...

ea0032p877 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Hypopituitarism after fractionated stereotactic radiation therapy of anterior skull base meningiomas is caused by mass effects, not radiation

Moeller Emil , Astradsson Arnar , Klose Marianne , Roed Henrik , Feldt-Rasmussen Ulla , Juhler Marianne

Introduction: Fractionated stereotactic radiotherapy (FSRT) is used in the treatment of surgically inaccessible meningiomas, primarily in the base of the skull. Development of hypopituitarism following FSRT is inexhaustively investigated. We aimed to elucidate the cause of hypopituitarism in patients treated with FSRT for benign meningiomas of the anterior skull base.Methods: All patients undergoing FSRT for benign meningioma of the skull base between Ju...