Endocrine Abstracts

The aim of the study is to compare efficacy of RAI in patients with Graves disease using different methods calculation of optimum therapeutic activity.Methods: About 60 patients (50 women, 10 men, mean age 44.8±11.8 years) with Graves decease were treated with RAI. The treatment with ATD was cancel 10 days before RAI to restore the iodine intake by thyroid gland. Therapeutic activity was determent individually 1) with applied the special formula in ...

Background: Peptic ulcer bleeding due to primary hyperparathyroidism is extremely rare and only a few cases have been reported in the literature.Material and methods: Man with repeated upper gastrointestinal bleeding, with a history of kidney stones and previously unknown primary hyperparathyroidism.Case: Man M., 46 y.o., with a history of 4 episodes of gastrointestinal bleeding and a ten-year history of multiple kidney stones. In ...

Background: Topical glucocorticoids (GCS) are seems to have low percent of adverse effects (AE). However, inappropriate use led to AE.Material and methods: One patient with psoriasis received topical GCS (clobetasol), one patient with coxarthrosis - steroid injections (diprospan).Cases: Woman A., 32 y.o., applied topical GCS (clobetasol) for 9 weeks for psoriasis. Area of application – abdomen and elbows. Frequency of applicat...

Introduction: Pituitary apoplexy is the rare case of panhypopituitarism. We are presenting a clinical case of pituitary apoplexy in a previously healthy 37-year-old woman.Case report: A 37-year-old woman developed amenorrhea in August 2011. She did not visit a doctor in that time. In December 2011 she suddenly felt severe headache, symptoms of polyuria and polydipsia and temperature of 39 °C. Laboratory results revealed an increased erythrocyte sedi...

Introduction: Resistance to thyroid hormone (RTH) is a rare disorder characterized by reduced tissues’s responsiveness to thyroid hormones (TH). Usually patients with RTH have not clinical signs except goiter. We describe a 70-years old woman with RTH and autoimmune thyroiditis simultaneously.Case report: Woman 70-years old was hospitalized in our department on August 2011 with suspicious of Thyrotropinoma because of high levels of TSH and fT4<...

A 31-year-old female patient without previous history of pituitary diseases, at 16 weeks of 4th spontaneous pregnancy complained about severe headache; diplopia and right ptosis developed shortly, nausea and vomiting appeared. Brain MRI showed the mass lesion 30×19×14 mm (frontal×vertical×sagittal) with supra-laterosellar extension, deforming and displacing optic chiasm; signs of pansinusitis, pathological contents of the right mastoid cells, vascular malfo...

Objective: To study the frequency and features of mental disorders in hospitalized patients, suffering from Cushing’s disease (CD).Materials and methods: We studied 70 patients (59 women and 11 men) with verified diagnosis of CD, aged 41±12 years. Their mental health was evaluated with ICD-10 criteria and verified by the Mini-International Neuropsychiatric Interview questionnaire (MINI 6.0). 45 patients had overt hypercortisolism (untreated CD ...

Background: Menstrual abnormalities (MA) can be the first sign of the disease.Aim: To assess the structure of MA before and after treatment of CD.Material and methods: Twenty-eight women with CD 39 (31.8;43.5) y.o., were investigated initially and 3.5 (2;5.5) years after treatment. Patients were subdivided into three groups: with normal cycles (NC; 26–30 days), oligomenorrhea (31–120 days), amenorrhea (>120 days)....

Background: Patients with Cushing’s syndrome (CS) have a lot of complications due to chronic exposure of cortisol.Aim: To reveal specific changes of cardiovascular system in patients with CS.Material and methods: i) Six patients with CS (five females, one male, 47.1±1.5 years old), duration of CS 3.4±1.2 years, ii) 19 healthy patients (48.1±3.0 years old), and iii) ten patients with ischemic heart disease (IHD) ...

Background: Pregnancy occurs rarely in Cushing’s syndrome (CS), slightly over 150 cases have been reported in the literature. The risk of maternal morbidity and a poor fetal outcome is significant when CS coexists with pregnancy. CS may be difficult to detect clinically and laboratory because of the hormonal changes and pathological comorbidities associated with normal pregnancy.Material and methods: A case of CS that was diagnosed and treated durin...