Endocrine Abstracts

Objective: The CYP3A7 enzyme metabolizes some steroid hormones including dehydroepiandrosterone sulphate (DHEAS). Its expression silenced after birth. Previous study has shown that in case of CYP3A7*1C polymorphism, CYP3A7 enzyme activity persisted a higher level, resulting lower levels of DHEAS in men. The age-related decline of serum DHEAS levels is believed to contribute to osteoporosis. We hypothesized that CYP3A7*1C contribute bone loss through decreased level of serum DH...

Insulinomas are predominantly benign pancreatic neuroendocrine tumors presenting with hyperinsulinemic hypoglycemia. Patients with significant hypoglycemic episodes can pose a management challenge. Based on the extent and the aggressiveness of the disease patients may be offered different treatment regimens. Although surgical resection is currently the standard treatment for pancreatic insulinoma, alternative treatment options, such as endoscopic ultrasound-guided fine needle ...

Second malignant neoplasm following irradiation is a rare sequelae of primary childhood malignancies. Irradiation is a well-known risk factor for the development of benign and malignant thyroid tumors. Here we present the case of a young woman with medulloblastoma, who later developed thyroid cancer and eventually was also diagnosed with a cholangiocarcinoma.At the age of 7 the patient presented with headaches, nausea, vomiting, fatigue, somnolence and d...