Endocrine Abstracts

Introduction: Weight concerns are common in endocrine outpatients. Weight indices seem to have a complex interaction with thyroid function. The two have not been studied in eastern Mediterranean populations.Methods: Prospective collection of baseline data on weight, BMI and thyroid function on consecutive patients presenting to an endocrinology outpatients. The setting included a medical centre in Limassol, Cyprus. Exclusion criteria were as follows: age...

Introduction: It is currently unclear how hyperthyroidism and its treatment impact on the weight trajectory of an individual. Anticipated weight gain with the treatment of hyperthyroidism is one of the main concerns of patients.Methods: We prospectively examined the BMI changes that occurred with hyperthyroidism and its therapy and sought risk factors for treatment-related weight gain. An established institutional protocol for the management of hyperthyr...

Background: Subacute thyroiditis is a self-limited inflammatory thyroid disorder with a triphasic clinical course of thyrotoxicosis, hypothyroidism, and return to euthyroidism. Whilst glucocorticoid (GC) treatment is advocated for managing moderate-to-severe symptoms, the ideal initiating dose and titration regime is unclear. Traditionally, doses of up to 40 mg of prednisolone have been used. More recently, to minimize adverse effects, a 15 mg initiation dose of ...

Background: Subacute thyroiditis is a self-limited inflammatory thyroid disorder with a triphasic clinical course of thyrotoxicosis, hypothyroidism, and return to euthyroidism. Whilst glucocorticoid (GC) treatment is advocated for managing moderate-to-severe symptoms, the ideal initiating dose and titration regime is unclear. Traditionally, doses of up to 40 mg of prednisolone have been used. More recently, to minimize adverse effects, a 15 mg initiation dose of ...

Introduction: Most studies which scrutinized the ATA 2015 thyroid nodule guidelines were performed retrospectively, in tertiary centers of excellence and in Western populations. We sought to prospectively apply these guidelines, under ‘real world’ conditions and in an eastern Mediterranean population.Methods: Thyroid nodules were prospectively and independently assessed by two experienced sonographers and classified as per the guidelines. Only ...

Background: The internet is widely consulted for health-related information (HRI). Online health information (OHI) seeking behaviors have never been investigated in the field of endocrinology.Objective: We examined the frequency, how and why the internet is utilized for HRI, the impact of such activity and the future information needs of our patients.Methods: A cross-sectional mixed-methods study was performed with more quantitativ...

A 40-year-old lady who was 4 months postpartum, presented with clinical and biochemical features consistent with post partum thyroiditis associated with neck swelling. She had a family history of autoimmune thyroid disease. She underwent ultrasound guided fine-needle aspiration (FNA) biopsy which was reported as Thy3f and listed for diagnostic hemithyroidectomy. She presented to us for a second opinion. She was on replacement therapy and the anterior neck swelling has...

Background: The internet is becoming an increasingly important medium for health-related information and is considered a means for aiding patient empowerment. Online health information (OHI) seeking behavior has never been studied in the field of endocrinology.Objective: We set out to examine the frequency, how and why the internet is utilized for health-related information and the impact of such activity. Future information needs were also investigated....

Background: Pembrolizumab is a novel anti-cancer drug that targets programmed cell death protein 1 (PD-1) receptor on lymphocytes resulting in their activation against tumor cells. PD-1 receptors are also distributed in endocrine organs and pembrolizumab use has long-been associated with hypophysitis and thyroiditis. We describe a patient with pembrolizumab-induced thyroiditis who developed an uncommon fulminant Type 1 Diabetes Mellitus (FT1D).Case prese...

Introduction: Lymphocytic hypophysitis (LH) is a rare condition that has been increasingly recognised. We studied the natural history and current management of patients with lymphocytic hypophysitis.Methods: We performed a multi-centre retrospective review of all patients that either had histologically proven disease or a strong clinical suspicion for its presence, diagnosed from 2000 onwards. Cases of secondary hypophysitis or granulomatous or xanthomat...