Endocrine Abstracts

Introduction: Multiple Endocrine Neoplasia Syndrome 2B (MEN 2B) is a very rare genetic disorder which affects the thyroid and the adrenal glands, the development of mucosal neuromas and the general appearance of the patient’s body. Therefore, we can encounter Medullary Thyroid Carcinomas (MTC), adrenal sympathetic paragangliomas (or Pheochromocytomas) and habitus Marfanoid. The disease represents a challenge for every clinician, especially if it occurs in a child.<p c...

Case presentation: A 67-year old diabetic and hypertensive female, with no significant family history, first underwent total thyroidectomy, with a histological and immunohistochemical result of both papillary thyroid carcinoma (PTC) T3Nx stage III and medullary thyroid carcinoma (MTC), with additional radioiodine treatment for PTC, showing excellent response to therapy at follow-ups (stimulated thyroglobulin <0.2 ng/ml, normal CEA and calcitonin). Almost 10 years later, th...

Medullary thyroid carcinoma (MTC) is a rare malignancy arising from parafollicular C cells of the thyroid gland, sometimes due to germline mutations in the RET protooncogene. Testicular cancer is the most common malignancy in men aged 15 - 40 years with survival rates improved by the introduction of cisplatin therapy in the late 1970s. Nonetheless, platinum-based chemotherapy was shown to increase the risk of a solid second cancer with substantially increased site-specific ris...

Introduction: Ectopic ACTH syndromes account for 5–10% of Cushing syndrome, with intrathoracic and gastrointestinal–pancreatic neuroendocrine tumors being the most common causes, followed by small cell lung cancer, adrenal paraganglioma and medullary thyroid carcinoma.Case report: A 50-year-old male hypertensive and diabetic patient was transferred to our clinic for emergency endocrine care for hypokalemia. He had mild hypercortisolism and live...

Background: BMAD is defined as development of multiple large nodules, >1 cm diameter, with bilateral involvement of the adrenal glands. It is typically associated with endogenous Cushing’s syndrome (CS) and occurs in adults, in the 4th-7th decade of life.Aim: To describe the clinical presentation, the biochemical peculiarities and the management of 71 patients diagnosed with BMAD in a tertiary endocrinology centre.Results:...