Searchable abstracts of presentations at key conferences in endocrinology

ea0037mte12 | (1) | ECE2015

Medullary thyroid cancer

Links Thera P

Medullary thyroid cancer (MTC) is a rare disease accounting for about 5% of all thyroid cancers and can occur sporadically (75%) or as part of the familial syndrome multiple endocrine neoplasia type 2 (MEN 2). The hereditary forms are caused by a mutation in the ‘rearranged during transfection’ (RET) gene.When a proven RET mutation is present carriers will be offered a prophylactic thyroidectomy. The timing of this prophylactic procedure is not...

ea0084ps3-14-124 | Thyroid Cancer CLINICAL 2 | ETA2022

Evaluating prognostic markers for stage migration in medullary thyroid cancer

Jager Eline , Metman Madelon , Burgerhof Hans , Kruijff Schelto , Links Thera

Background: Medullary thyroid cancer (MTC) is a rare malignancy with a variable and sometimes unpredictable disease course. To predict the course of disease more accurately at diagnosis, we introduce dynamic risk stratification by analyzing factors related to “stage migration” within the first 5 years after diagnosis.Methods: All patients diagnosed at the University Medical Center of Groningen between 1999 and 2015 were retrospectively studied....

ea0016p803 | Thyroid | ECE2008

Thyroid peroxidase antibodies and levels of thyroid stimulating hormone as predictors of development of hypothyroidism in euthyroid subjects

Roos Annemieke , Links Thera , Jong-van den Berg Lolkje de , Gans Rijk , Wolffenbuttel Bruce , Bakker Stephan

Introduction: Presence of thyroid peroxidase antibodies (TPOAbs) may be a marker of future thyroid failure. However, prospective studies in a euthyroid population have not been performed.Aim of the study: To prospectively investigate the relationship between presence and levels of TPOAbs and incident hypothyroidism in euthyroid subjects in the general population.Study population: The database used for this study consisted of a rand...

ea0092op-01-01 | Oral Session 1: Highlights in Thyroidology: in Memory of Jacques Dumont | ETA2023

Patient-Derived medullary thyroid cancer organoids; a model for patient-tailored drug and tracer screening

Jager Eline , Sondorp Luc , Antunes Ines , Jansen Liesbeth , Brouwers Adrienne , Links Thera , Coppes Robert , Kruijff Schelto

Background: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor derived from the parafollicular C-cells of the thyroid gland. Mutations in the gene encoding the Rearranged during Transfection (RET) tyrosine kinase, play a vital role in the development of MTCs. In patients with distant metastases, only targeted therapy can prolong survival. Tyrosine kinase inhibitors (TKIs) block tyrosine kinases such as RET and thereby inhibit tumor proliferation. However, it is diffic...

ea0084ps3-15-135 | Thyroid Cancer Diagnosis & Treatment | ETA2022

Clinical relevance of lower titer thyroglobulin (TG) autoantibodies in patients with differentiated thyroid carcinoma

Dekker Bernadette , van der Horst-Schrivers Anouk , Brouwers A.H. , Shuford Chris , Kema Ido , Muller Kobold Anneke , Links Thera

Objectives: Thyroglobulin (Tg) is an established tumor marker for differentiated thyroid carcinoma (DTC) patients. However, Tg immunoassays can be subject to autoantibody (TgAb) interference resulting in incorrect Tg values. Tg measurement with liquid chromatography-tandem mass spectrometry (LC-MS/MS) could be promising in patients with TgAbs. In this study, we compared a Tg immunoradiometric assay (Tg-IRMA) and a Tg-LC-MS/MS analytically in the presence of TgAbs. Furthermore,...

ea0049oc9.1 | Thyroid Disease 2 | ECE2017

Thyroid function and metabolic syndrome: results from the population-based LifeLines Cohort study

Wolffenbuttel Bruce , Wouters Hanneke , Slagter Sandra , van Waateringe Robert , van Vliet-Ostaptchouk Jana , Links Thera , van der Klauw Melanie

Background: The metabolic syndrome (MetS) is a combination of unfavourable health factors including abdominal obesity, dyslipidaemia, hypertension and impaired fasting glucose. Several small-scale studies have reported a relationship between thyroid function and some MetS components or suggested that serum FT3 levels within the normal range were independently associated with insulin resistance. We assessed how thyroid function relates to the prevalence of MetS in a large popul...

ea0056gp193 | Pituitary / Growth Hormone ' IGF Axis | ECE2018

Hypophysitis due to immune checkpoint blockade: rising numbers.

van den Berg Gerrit , van den Brom Rob , van der Klauw Melanie , Hiltermann Jeroen , Hospers Geke , Links Thera

Hypophysitis is one of the immune-related adverse events of immune checkpoint blockade. This complication is potentially dangerous, mainly because of the insidious development of a life-threatening hypocortisolism. Unnecessary morbidity or mortality in an oncological responder may be the result. The number of patients treated with immune checkpoint inhibitors increases rapidly, due to the expansion of indications and trials. Moreover, the introduction of combination schedules ...

ea0092op-04-06 | Oral Session 4: Young Investigators / Clinical and Translational | ETA2023

Cardiac function during early treatment for differentiated thyroid carcinoma

Links Mirthe , Lefrandt Joop , Van Der Boom Trynke , Willems Tineke , van der Meer Peter , Links Thera , Zandee Wouter

Background: Differentiated thyroid carcinoma (DTC) survivors have an increased risk of cardiovascular mortality but, the pathophysiological mechanism remains largely unknown. Early treatment for high-risk DTC entails thyroid surgery, radioiodine therapy with thyroid hormone (TH)-withdrawal, and thyroxine suppression therapy (THST). During treatment, patients cycle from severe hypothyroidism to exogenous subclinical hyperthyroidism. TH changes in early DTC treatment might affec...

ea0092op-05-02 | Oral Session 5: Young Investigators / Basic | ETA2023

Thyroid tumor microenvironment: deconvolution of tumor composition using DNA methylation data

Rodriguez-Lloveras Helena , Carmela Iglesias , Klein Hesselink Esther , Lluis Reverter Jordi , Links Thera , Carles Zafon , Jorda Mireia

Introduction: Most thyroid cancer (TC) patients have a good prognosis, but some of them show aggressive behavior and are resistant to treatment. Still no effective biomarkers are available to predict which patients will progress. Epigenetic alterations are a hallmark of cancer, and profiling DNA methylation has allowed a better understanding of the epigenetic landscape of TC and its influence in TC progression. However, bulk DNA methylomes include information not only from tum...

ea0037gp.29.07 | Endocrine tumours and neoplasia – Adrenal Tumour | ECE2015

Penetrance and optimal surveillance for SDHB mutation carriers

Eijkelenkamp Karin , Osinga Thamara E , de Jong Mirjam M , Sluiter Wim J , Dullaart Robin P F , Links Thera P , Kerstens Michiel N , van der Horst-Schrivers Anouk N A

Context: Germline mutations of the gene encoding succinate dehydrogenase subunit B (SDHB) predispose to head and neck paraganglioma (HNPGL), sympathetic PGL, phaeochromocytoma and renal cell carcinoma for which regular surveillance is required. SDHB-associated tumors harbor germline and somatic mutations, consistent with Knudson’s two-hit hypothesis stating that the combination of an inactivating germline mutation as a first hit and somatic loss of funct...